Results 1 to 10 of about 42,692 (73)
Antioxidants, 2022 The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO), ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin reductase (BVR).
S. Ryter
semanticscholar +1 more source
A Dual Role of Heme Oxygenase-1 in Tuberculosis
Frontiers in Immunology, 2022 Iron metabolism is vital for the survival of both humans and microorganisms. Heme oxygenase-1 (HO-1) is an essential stress-response enzyme highly expressed in the lungs, and catabolizes heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV ...
Sen Yang +4 more
semanticscholar +1 more source
Roles of Heme Oxygenase-1 in Neuroinflammation and Brain Disorders
Antioxidants, 2022 The heme oxygenase (HO) system is believed to be a crucial mechanism for the nervous system under stress conditions. HO degrades heme to carbon monoxide, iron, and biliverdin.
Yi‐Hsuan Wu, H. Hsieh
semanticscholar +1 more source
Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions
Biomolecules, 2021 Heme-oxygenase is the enzyme responsible for degradation of endogenous iron protoporphyirin heme; it catalyzes the reaction’s rate-limiting step, resulting in the release of carbon monoxide (CO), ferrous ions, and biliverdin (BV), which is successively ...
Valeria Consoli +3 more
semanticscholar +1 more source
The Diverse Roles of Heme Oxygenase-1 in Tumor Progression
Frontiers in Immunology, 2021 Heme oxygenase-1 (HO-1) is an inducible intracellular enzyme that is expressed in response to a variety of stimuli to degrade heme, which generates the biologically active catabolites carbon monoxide (CO), biliverdin and ferrous iron (Fe2+).
Kim Ngan Luu Hoang +2 more
semanticscholar +1 more source
Blood, 2021 Sickle cell disease (SCD) is characterized by increased hemolysis which results in plasma heme overload and ultimately cardiovascular complications. Here, we hypothesized that increased heme in SCD causes upregulation of heme oxygenase 1 (Hmox1) which ...
Archita V. Menon +6 more
semanticscholar +1 more source
Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
Antioxidants, 2021 Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of ...
Jose Angel Alonso-Piñeiro +4 more
semanticscholar +1 more source
Clinical Significance of Heme Oxygenase 1 in Tumor Progression
Antioxidants, 2021 Heme oxygenase 1 (HO-1) plays a key role in cell adaptation to stressors through the antioxidant, antiapoptotic, and anti-inflammatory properties of its metabolic products.
M. Nitti +3 more
semanticscholar +1 more source
On a class of Hessian type equations on Riemannian manifolds [PDF]
Proceedings of the American Mathematical Society, 2021, 2022 In this paper, we consider a class of Hessian type equations which include the $(n-1)$ Monge-Amp\`{e}re equation on Riemannian manifolds. The \emph{a priori} $C^2$ estimates and the existence of solutions are established.
arxiv +1 more source
Fabrication of electronically conductive protein-heme nanowires for power harvesting [PDF]
Small, 2024, 2311661, 2023 Electronically conductive protein-based materials could enable the creation of bioelectronic components and devices from sustainable and nontoxic materials, while also being well-suited to interface with biological systems, such as living cells, for biosensor applications.
arxiv +1 more source