Results 1 to 10 of about 100,369 (340)
Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1 [PDF]
Haematologica, 2015 Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Ceri Evans +6 more
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Neural Regeneration Research, 2023 Interfering with the ferroptosis pathway is a new strategy for the treatment of spinal cord injury. Fibroblast growth factor 21 can inhibit ferroptosis and promote neurofunctional recovery, while heme oxygenase-1 is a regulator of iron and reactive ...
Qi Gu +10 more
doaj +2 more sources
Heme, Heme Oxygenase-1, Statins, and SARS-CoV-2
Antioxidants, 2023 Heme, a metalloporphyrin, or more specifically, a tetrapyrrole containing ferrous iron, is an ancient molecule [...]
David K. Stevenson +2 more
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Regulation of Complement Activation by Heme Oxygenase-1 (HO-1) in Kidney Injury [PDF]
Antioxidants, 2021 Heme oxygenase is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties. Its cytoprotective role is mainly attributed to its enzymatic activity, which involves the degradation of heme to biliverdin with simultaneous release of ...
Maria G. Detsika, Elias A. Lianos
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Heme oxygenase-1 and malaria pathogenesis [PDF]
Frontiers in ImmunologyMalaria is a life-threatening parasitic disease and remains a major cause of morbidity and mortality worldwide. The clinical course of malaria ranges from uncomplicated infection to severe disease, driven by extensive hemolysis, inflammation, and ...
Theophilus Wakai +4 more
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How Heme Oxygenase-1 Prevents Heme-Induced Cell Death. [PDF]
PLoS ONE, 2015 Earlier observations indicate that free heme is selectively toxic to cells lacking heme oxygenase-1 (HO-1) but how this enzyme prevents heme toxicity remains unexplained.
Lilibeth Lanceta +3 more
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Heme oxygenase-1, oxidation, inflammation and atherosclerosis [PDF]
Frontiers in Pharmacology, 2012 Atherosclerosis is an inflammatory process of the vascular wall characterized by the infiltration of lipids and inflammatory cells. Oxidative modifications of infiltrating low density lipoproteins and induction of oxidative stress play a major role in ...
Jesus A Araujo, Min eZhang, Fen eYin
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Heme oxygenase-1 deletion affects stress erythropoiesis. [PDF]
PLoS ONE, 2011 BACKGROUND:Homeostatic erythropoiesis leads to the formation of mature red blood cells under non-stress conditions, and the production of new erythrocytes occurs as the need arises.
Yu-An Cao +5 more
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Immune-Related Functions of Heme Oxygenase-1
Antioxidants, 2023 Heme oxygenase (HO)-1 is a well-known cytoprotective enzyme due to its enzymatic action, which involves the catalysis of heme into anti-apoptotic and antioxidant molecules such as bilirubin, biliverdin and CO [...]
Elias A. Lianos, Maria G. Detsika
doaj +4 more sources
Heme catabolism and heme oxygenase-1-expressing myeloid cells in pathophysiology [PDF]
Frontiers in ImmunologyAlthough the pathological significance of myeloid cell heterogeneity is still poorly understood, new evidence indicates that distinct macrophage subsets are characterized by specific metabolic programs that influence disease onset and progression. Within
Francesca Maria Consonni +10 more
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