Results 231 to 240 of about 188,137 (274)

Cooperative Photometallobiocatalysis: Nonheme Fe Enzyme‐Catalyzed Enantioconvergent Radical Decarboxylative Azidation, Thiocyanation, and Isocyanation of Redox‐Active Esters

Angewandte Chemie, Volume 137, Issue 29, July 14, 2025.
Through the directed evolution of an underexploited nonheme Fe extradiol dioxygenase, we developed a unified cooperative photobiocatalytic strategy to allow for three types of enantioconvergent radical transformations, including azidation, thiocyanation, and isocyanation.
Liu‐Peng Zhao, Ken Lin, Pei‐Pei Xie, Huichong Liu, Hengye Xiang, Xin Liu, Yunlong Zhao, Peng Liu, Yang Yang   +8 more
wiley   +2 more sources

Structural Basis for Methine Excision by a Heme Oxygenase-like Enzyme. [PDF]

ACS Cent Sci
Simke WC, Walker ME, Calderone LA, Putz AT, Patteson JB, Vitro CN, Zizola CF, Redinbo MR, Pandelia ME, Grove TL, Li B.   +10 more
europepmc   +1 more source

Canagliflozin protects cardiovascular function in type 2 diabetic coronary artery disease by regulating natriuretic peptide B

Journal of Diabetes Investigation, Volume 16, Issue 8, Page 1430-1444, August 2025.
Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang, Lichenlu Huang, Yongqin Zheng, Ji Yang, Xiaopei Wu, Jundong He   +5 more
wiley   +1 more source

Heme Oxygenase-1 Modulates Macrophage Polarization Through Endothelial Exosomal miR-184-3p and Reduces Sepsis-Induce Lung Injury. [PDF]

Int J Nanomedicine
Chen W, Zhang Y, Chen J, Dong S, Wu X, Wu Y, Du Z, Yang Y, Gong L, Yu J.   +9 more
europepmc   +1 more source

Genome‐Wide Analysis of DtxR and HrrA Regulons Reveals Novel Targets and a High Level of Interconnectivity Between Iron and Heme Regulatory Networks in Corynebacterium glutamicum

Molecular Microbiology, Volume 124, Issue 2, Page 115-130, August 2025.
Iron is essential for life, yet excessive levels can quickly lead to cellular damage via oxidative stress, underscoring the need for global regulators of iron and heme homeostasis. In this study, we present a genome‐wide analysis of the binding patterns of DtxR and HrrA in Corynebacterium glutamicum . Our findings highlight the interconnected nature of
Aileen Krüger, Ulrike Weber, Julia Frunzke   +2 more
wiley   +1 more source

Erianin mitigates diabetic cardiomyopathy <i>via</i> adenosine monophosphate-activated protein kinase-nuclear factor erythroid 2-related factor 2-heme oxygenase-1 pathway activation. [PDF]

World J Diabetes
Chen JH, Dai XC, Quan ZJ, Liu XY.
europepmc   +1 more source

Salvianolic Acid B Attenuates Ferroptosis in Acute Kidney Injury by Targeting PRDX5

The FASEB Journal, Volume 39, Issue 14, 31 July 2025.
Mechanistic diagram of SAB‐mediated alleviation of AKI through the regulation of PRDX5‐mediated ferroptosis in renal tubular epithelial cells. SAB alleviates cisplatin‐ and FA‐induced AKI by inhibiting ferroptosis via PRDX5‐mediated upregulation of SLC7A11, GPX4, and FSP1.
Yan Tao, Shengjun Fu, Jianzhong Lu, Beitang Fu, Shanhui Liu, Lanlan Li   +5 more
wiley   +1 more source

Heme oxygenase-1 and anti-inflammatory M2 macrophages.

Archives of Biochemistry and Biophysics, 2014
Y. Naito, T. Takagi, Yasuki Higashimura
semanticscholar   +1 more source

Investigating the causal association between heme oxygenase-1 and asthma: A bidirectional two-sample Mendelian randomization analysis in a European population. [PDF]

World Allergy Organ J
Liu W, Liu Z, Sun XD, Liu ZQ, Dong YY, Qiu S.   +5 more
europepmc   +1 more source