Results 221 to 230 of about 115,890 (298)

Individual and Combined Cardioprotective Effects of 1,25(OH)2D3 and Dimethyl Fumarate in an Isoproterenol‐Induced Myocardial Injury Model

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
1,25(OH)2D3 and dimethyl fumarate, administered alone or in combination, provide significant cardioprotection against isoproterenol‐induced myocardial injury by reducing oxidative stress, inflammation, and structural damage through modulation of the Nrf2/NF‐κB signaling pathways and the renin–angiotensin system (RAS).
Fatma Hande Karpuzoğlu, Serhat Kilinç, İlayda Sözmen, İlknur Bingül, Abdurrahman Fatih Aydin, Aysel Bayram, Semen Önder, Efe Akçe, Semra Doğru‐Abbasoğlu, Müjdat Uysal   +9 more
wiley   +1 more source

Protective role of heme oxygenase in CsA-induced nephrotoxicity

, 2004
BUFFOLI, Barbara, RODELLA, Luigi Fabrizio, LIVOLTI G, ABRAHAM NG, REZZANI, Rita, GOODMAN AI, BIANCHI R   +6 more
core   +1 more source

Elevated serum heme oxygenase-1 in pediatric sickle cell disease: Insights from the SickleGenAfrica Network. [PDF]

Hemasphere
Sowa AM, Kudzi W, Paintsil V, Benneh-Akwasi Kuma AA, Segbefia CI, Olayemi E, Adjei DN, Bruce ANK, Gruen JR, Owusu-Dabo E, Ofori-Acquah SF, SickleGenAfrica Network.   +11 more
europepmc   +1 more source

Nrf2–Keap1 Axis Modulation by Phytofabricated Metal Oxide Nanoparticles in Mesenchymal Stem Cell Lineage Bias

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Phytofabricated metal oxide nanoparticles may activate the Nrf2–Keap1 axis through a dual‐stimulus mechanism, coupling nanoparticle‐derived ROS with phytochemical‐mediated Keap1 modification, steering mesenchymal stem cells toward osteogenic commitment — a mechanistic framework this review consolidates from current evidence.
Muhammad Irfan, Muhammad Taha, Syed Muhammad Faizan Asghar, Muhammad Raza   +3 more
wiley   +1 more source

Fetuin-A and Heme Oxygenase 1 as Potential New Markers in the Diagnosis of Diabetic Kidney Disease. [PDF]

Int J Mol Sci
Król-Kulikowska M, Przyborska A, Miernikiewicz E, Roszykiewicz P, Roszykiewicz W, Banasik M, Kepinska M.   +6 more
europepmc   +1 more source

Icariside II in Neurological Disorders: Mechanistic Insights Into Alzheimer's Disease, Cerebral Ischemia and Parkinson's Disease

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract represents the underlying neuroprotective potential of ICS II against Alzheimer's disease, Cerebral ischemia and Parkinson disease. ICS II downregulates ROS production, inflammation, mitochondrial dysfunction and apoptosis along with regulating their key signalling pathways.
Ashutosh Solanki, Khushi Sharma, Jagrati Jain, Niraj Kumar Singh, Praveen T. Krishnamurthy   +4 more
wiley   +1 more source

Obeticholic Acid and Edaravone Protect Against Cisplatin‐Induced Hepatotoxicity Through Modulation of Keap1/Nrf2/ARE, TNF‐α/NF‐κB, and AKT/GSK‐3β Pathways

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The graphical abstract explores the possible underlying molecular mechanisms of Obeticholic acid against hepatotoxicity induced by chemotherapy exposure. ABSTRACT Hepatotoxicity is one of the most crucial side effects of chemotherapy administration. Obeticholic acid (OCA) is a semisynthetic bile acid and farnesoid X receptor (FXR) agonist derived from ...
Fares E. M. Ali, Adel G. Bakr, Abdel‐Gawad S. Shalkami, Ehab A. M. El‐Shoura, Lamiaa Khalaf Ahmed, Ali F. Abd‐Elsalam, Ahmed A. N. Ahmed, Emad H. M. Hassanein   +7 more
wiley   +1 more source

Exploring the Differential Impact of Melatonin Timing Administration (Day vs. Night) on Mitigating Cerebellar Damage Caused by Monosodium Glutamate in Rats

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Exogenous melatonin, especially when given at night, provides strong neuroprotective benefits by influencing circadian serum melatonin levels. It inhibits PI3K‐dependent inflammatory signaling and encourages the nuclear translocation of NRF2, along with activation of the NRF2/HO‐1 antioxidant pathway.
Alaa Gamal Ahmad, Noha M. Abd El‐Fadeal, Horeya Erfan Korayem Arafat, Dalia Ibrahim Ahmed, Rasha Atta   +4 more
wiley   +1 more source

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti‐Inflammatory Effects but Upregulates HO‐1 and Alters Adiponectin Levels in Human Adipocytes

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Johanna Matilainen, Sanni Foster, Viivi Berg, Janne Tampio, Tanja Turunen, Anne‐Mari Mustonen, Heikki Kyykallio, Maija Vaittinen, Ville Männistö, Jussi Pihlajamäki, Marjo Malinen, Sanna Oikari, Pirjo Käkelä, Dorota Kaminska, Veera Luukkonen, Kristiina M. Huttunen, Martin Wabitsch, Petteri Nieminen, Kirsi Rilla   +18 more
wiley   +1 more source

Deep learning‐assisted design of nanozyme for immune regulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 250-276, September 2026.
Overview of nanozyme‐based strategies for inflammatory bowel disease therapy, featuring metal‐based and non‐metallic nanozymes classified by structure, alongside multifunctional and engineered probiotic‐based nanozymes classified by function. Abstract Inflammatory bowel disease (IBD), with rising global incidence and disease burden, is a multifactorial
Ke Chen, Si Sun, Shaofang Zhang, Huanhuan Qiao   +3 more
wiley   +1 more source