Low levels of nitric oxide promotes heme maturation into several hemeproteins and is also therapeutic [PDF]
Redox Biology, 2022 Nitric oxide (NO) is a signal molecule and plays a critical role in the regulation of vascular tone, displays anti-platelet and anti-inflammatory properties.
Dennis J Stuehr +2 more
exaly +4 more sources
Bio-Electroanalysis Performance of Heme Redox-Center for π-π Interaction Bonding of a Methylene Blue-Graphene Modified Electrode [PDF]
Nanomaterials, 2023 Hemeprotein detection has motivated extensive research on the direct reaction of a heme molecule and a redox dye. The present study used methylene blue as both donor and acceptor for a redox reaction.
Porntip Khownarumit +5 more
doaj +2 more sources
Behind the Optimization of the Sensor Film: Bioconjugation of Triangular Gold Nanoparticles with Hemoproteins for Sensitivity Enhancement of Enzymatic Biosensors [PDF]
Biosensors, 2023 Electrochemical biosensors are widely used in a multitude of applications, such as medical, nutrition, research, among other fields. These sensors have been historically used and have not undergone many changes in terms of the involved electrochemical ...
Miriam Chávez +6 more
doaj +2 more sources
Heme allocation in eukaryotic cells relies on mitochondrial heme export through FLVCR1b to cytosolic GAPDH [PDF]
Nature CommunicationsHeme is an iron-containing cofactor generated in mitochondria that must leave this organelle to reach protein targets in other cell compartments. Because mitochondrial heme binding by cytosolic GAPDH enables its distribution in cells, we sought to ...
Dhanya Thamaraparambil Jayaram +5 more
doaj +2 more sources
Mechanistics of pH-Dependent Sulfmyoglobin Formation: Spin Control and His64 Proton Relay
Journal of ChemistryThe chemistry of hydrogen sulfide (H2S) has been directed towards physiologically relevant hemeproteins, including myoglobin, hemoglobin, and other similar proteins.
Angel D. Rodriguez-Mackenzie +4 more
doaj +2 more sources
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution. [PDF]
Bioessays, 2023 We hypothesize that tissues exist naturally in a heme‐deficient condition that limits the heme content and functions of heme proteins. The nitric oxide (NO) that is made in our tissues can control cell heme availability in a bimodal way, and so regulate heme protein functions in health and disease.
Stuehr DJ +5 more
europepmc +2 more sources
Biomedicines, 2022 The immune function is closely related to iron (Fe) homeostasis and allostasis. The aim of this bioinformatics-assisted review was twofold; (i) to update the current knowledge of Fe metabolism and its relationship to the immune system, and (ii) to ...
Diego A. Bonilla +9 more
doaj +1 more source
Angewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023 Computational modelling was employed to rationally guide protein engineering toward controlling the accessible conformations of a key lactone‐carbene (LAC) intermediate in the enzyme active site by installing a new H‐bond anchoring point. This H‐bonding interaction controls the relative orientation of the fleeting carbene intermediate, orienting it for
Carla Calvó‐Tusell +4 more
wiley +2 more sources
Antioxidants, 2022 Nitrobindins (Nbs) are all-β-barrel heme proteins and are present in prokaryotes and eukaryotes. Although their function(s) is still obscure, Nbs trap NO and inactivate peroxynitrite.
Giovanna De Simone +4 more
doaj +1 more source
Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter
Antioxidants, 2022 Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory,
Jianyun Liu +7 more
doaj +1 more source