Results 21 to 30 of about 2,121 (177)
A natural heme deficiency exists in biology that allows nitric oxide to control heme protein functions by regulating cellular heme distribution. [PDF]
Bioessays, 2023 We hypothesize that tissues exist naturally in a heme‐deficient condition that limits the heme content and functions of heme proteins. The nitric oxide (NO) that is made in our tissues can control cell heme availability in a bimodal way, and so regulate heme protein functions in health and disease.
Stuehr DJ +5 more
europepmc +2 more sources
Angewandte Chemie, Volume 135, Issue 35, August 28, 2023., 2023 Computational modelling was employed to rationally guide protein engineering toward controlling the accessible conformations of a key lactone‐carbene (LAC) intermediate in the enzyme active site by installing a new H‐bond anchoring point. This H‐bonding interaction controls the relative orientation of the fleeting carbene intermediate, orienting it for
Carla Calvó‐Tusell +4 more
wiley +2 more sources
Rhabdomyolysis as cause, consequence, or mimicker of myocardial infarction: A case report
Clinical Case Reports, Volume 11, Issue 11, November 2023., 2023 Key Clinical Message A timely diagnosis is essential to start appropriate therapy and to reduce risks of life‐threatening complications of rhabdomyolysis. Some cases can undergo differential diagnosis with other clinical conditions, e.g., myocardial infarction.
Marina Nasello +11 more
wiley +1 more source
Advanced Science, Volume 10, Issue 29, October 17, 2023., 2023 This study focuses on the molecular action of two histone chaperones: SET/template‐activating factor‐Iβ and nucleophosmin 1. It is shown how these chaperones have specificity for fully dismantled nucleosomes, characterized the histone eviction (removal) process, and its modulation by cytochrome c.
Pedro Buzón +5 more
wiley +1 more source
Mechanisms of Neuronal Damage in Acute Hepatic Porphyrias
Diagnostics, 2021 Porphyrias are a group of congenital and acquired diseases caused by an enzymatic impairment in the biosynthesis of heme. Depending on the specific enzyme involved, different types of porphyrias (i.e., chronic vs. acute, cutaneous vs.
Andrea Ricci +3 more
doaj +1 more source
Hydrogen Sulfide and Hemeproteins: Knowledge and Mysteries [PDF]
Antioxidants & Redox Signaling, 2011 Historically, hydrogen sulfide (H(2)S) has been regarded as a poisonous gas, with a wide spectrum of toxic effects. However, like ·NO and CO, H(2)S is now referred to as a signaling gas involved in numerous physiological processes. The list of reports highlighting the physiological effects of H(2)S is rapidly expanding and several drug candidates are ...
Ruth, Pietri +2 more
openaire +2 more sources
Hypoxic Regulation of the Large-Conductance, Calcium and Voltage-Activated Potassium Channel, BK
Frontiers in Physiology, 2021 Hypoxia is a condition characterized by a reduction of cellular oxygen levels derived from alterations in oxygen balance. Hypoxic events trigger changes in cell-signaling cascades, oxidative stress, activation of pro-inflammatory molecules, and growth ...
Sara V. Ochoa +9 more
doaj +1 more source
New insights into the role of heme oxygenase-1 in acute kidney injury
Kidney Research and Clinical Practice, 2020 Acute kidney injury (AKI) is attended by injury-related biomarkers appearing in the urine and serum, decreased urine output, and impaired glomerular filtration rate.
Meryl Nath, Anupam Agarwal
doaj +1 more source
Encapsulation of sugar beet phytoglobin BvPgb 1.2 and myoglobin in a lipid sponge phase system
Frontiers in Soft Matter, 2023 Globins are usually associated with oxygen carriage in vertebrates. However, plants also contain similar heme-containing proteins, called phytoglobins (Pgbs).
Jennifer Gilbert +7 more
doaj +1 more source