Results 71 to 80 of about 37,295 (215)
Inflammation can increase hepcidin in HFE‐hereditary hemochromatosis
Clinical Case Reports, 2021 We present a p.C282Y homozygous patient with high hepcidin levels and normal iron parameters during systemic inflammation. This suggests that in the absence of a proper functioning HFE, resulting in blockage of the BMP/SMAD pathway, the innate low ...
Wenke Moris +6 more
doaj +1 more source
Iron overload in hereditary spherocytosis: Are genetic factors the cause?
British Journal of Haematology, EarlyView.Summary Non‐transfusional iron overload (IOL) in hereditary spherocytosis (HS) is poorly documented compared with other red blood cell disorders. We studied 13 HS adults with confirmed IOL to identify potential genetic factors. Using a next‐generation sequencing panel of 46 genes related to HS, anaemia and iron metabolism, we found no association ...
Lucie Donaty +6 more
wiley +1 more source
Patients and blood donors with hemochromatosis: A survey conducted in Førde Health Trust
Bioingeniøren, 2021 Introduction: To allow eligible persons with hemochromatosis to become blood donors will be advantageous for these individuals and for the blood supply.
Turid Aarhus Braseth +2 more
doaj
Severe osteoporosis as atypical presentation of hereditary hemochromatosis
Clinical Case Reports, 2022 Besides important metabolic repercussions, iron overload is reported to be associated with deleterious effects on articulations and bones. We present the case of a male patient diagnosed with severe osteoporosis and vertebral fracture, in whom the ...
Georgiana Cristina Taujan +5 more
doaj +1 more source
The SOD2 C47T polymorphism influences NAFLD fibrosis severity: evidence from case-control and intra-familial allele association studies. [PDF]
, 2011 AIMS: Non-alcoholic fatty liver disease (NAFLD) is a complex disease trait where genetic variations and environment interact to determine disease progression.
Al Serri, Ahmad +10 more
core +1 more source
British Journal of Haematology, Volume 206, Issue 4, Page 1067-1076, April 2025.In iron‐refractory iron deficiency anaemia, inappropriately elevated hepcidin levels impair enteral iron absorption and iron release from macrophages by interacting with ferroportin. Oral iron supplements (containing ~30 mg Fe2+ per 100 mg) are generally ineffective due to this hepcidin–ferroportin interaction although, in some cases, this can be ...
V. Hoving +3 more
wiley +1 more source
A Rare Presentation of Transfusional Hemochromatosis: Hypogonadotropic Hypogonadism
Case Reports in Endocrinology, 2015 Hemochromatosis is a disease caused by extraordinary iron deposition in parenchymal cells leading to cellular damage and organ dysfunction. β-thalassemia major is one of the causes of secondary hemochromatosis due to regular transfusional treatment for ...
Rifki Ucler +6 more
doaj +1 more source
Anatomical Structure Segmentation in Liver MRI Images [PDF]
arXiv, 2012 Segmentation of medical images is a challenging task owing to their complexity. A standard segmentation problem within Magnetic Resonance Imaging (MRI) is the task of labeling voxels according to their tissue type. Image segmentation provides volumetric quantification of liver area and thus helps in the diagnosis of disorders, such as Hepatitis ...
arxiv
The effect of amino acid deprivation on the transfer of iron through Caco-2 cell monolayers [PDF]
, 2017 Funding Source Rural and Environmental Scientific and Analytical Services, the Scottish Government Acknowledgments We thank Dr Helen Hayes for her technical support during this project.
Cottin, Sarah +3 more
core +2 more sources
Diabetes, Obesity and Metabolism, EarlyView.Abstract Insulin has been discovered for more than a century; however, its benefits to people with diabetes are yet to be fully realized due to barriers related to access, quality of care and costs. Insulin therapy remains the cornerstone of diabetes management. The multicausality of diabetes and its subtypes calls for comprehensive phenotyping and use
Aimin Yang +4 more
wiley +1 more source