Results 141 to 150 of about 46,727 (267)

Dental considerations in the management of children suffering from sickle cell disease: A case report

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2007
Sickle cell disease (SCD) is a genetically derived disorder characterized by the presence of an abnormal hemoglobin molecule, designated as hemoglobin S (HbS).
Ramakrishna Y
doaj  

Unheard and Under‐Supported: Health‐Related Quality of Life in Children, Adolescents, and Young Adults With Sickle Cell Disease

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Background Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy affecting millions of individuals worldwide. The clinical expression and psychosocial burden of SCD vary widely across geographical, cultural, and healthcare system contexts, underscoring the need for setting‐specific approaches to assessment.
Desiré Fantasia, Giulia Reggiani, Elizabeth J. Maran, Maria Elisa Delle Fave, Ilaria Baido, Anna Chiara Frigo, Maria Paola Boaro, Raffaella Colombatti   +7 more
wiley   +1 more source

Molecular Methods for Rare Hemoglobinopathy Cases: First Brazilian Report of Pediatric Siblings with Hb O‐Arab and Alpha‐Thalassemia

Pediatric Blood &Cancer, Volume 73, Issue 5, May 2026.
ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk, Amanda Cristina Meneguetti Berti, Bárbara Braga Vieira Marques, Victoria Simões Bernardo, Flaviene Felix Torres, Ingrid Souza Dias, Vanessa da Silveira Ramos de Castro, Gabriela Alves Bernardino, Danilo Grünig Humberto da Silva, Edis Belini‐Júnior   +9 more
wiley   +1 more source

Genetic Contribution to Asthma Informs Acute Chest Syndrome Pathophysiology and Risk Stratification

American Journal of Hematology, Volume 101, Issue 5, Page 961-971, May 2026.
ABSTRACT Acute chest syndrome (ACS) is a severe complication of sickle cell disease (SCD) occurring in ~50% of patients, some presenting frequent episodes. We lack tools to identify patients at high risk of ACS occurrence or frequent episodes. Epidemiological studies have found an association between asthma and ACS, but whether this link is causal is ...
Sara El Aouhel, Vanessa Bellegarde, Stennio Da Silva Faria, Tristan St‐Laurent, Estelle Lecluze, Anne‐Laure Pham Hung d’Alexandry d’Orengiani, Frédéric Galactéros, Pablo Bartolucci, Marc‐André Legault, Guillaume Lettre, Thomas Pincez   +10 more
wiley   +1 more source

G‐CSF for Mobilizing CD34+ Cells in Individuals With SCD: A Word of Caution

American Journal of Hematology, Volume 101, Issue 6, Page 1178-1181, June 2026.
Akshay Sharma, Allistair Abraham, Monica Bhatia, María Cancio, Sonali Chaudhury, Selim Corbacioglu, Gregory M. T. Guilcher, Ashish O. Gupta, Rabi Hanna, Matthew M. Heeney, Tami John, Lakshmanan Krishnamurti, James L. LaBelle, Hemalatha G. Rangarajan, Shalini Shenoy, Elizabeth Stenger, Crawford Strunk, Courtney D. Fitzhugh   +17 more
wiley   +1 more source

Acute Soft Head Syndrome, A Rare Complication of Sickle Cell Anemia: A Case Report

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Acute soft head syndrome (ASHS) is a rare clinical complication of sickle cell disease (SCD). It presents as a progressive, non‐traumatic, and tender swelling of one or more areas of the scalp. Aetiopathophysiology is still less understood but hypothesized to be a result of loss of cortical skull bone integrity from increased extramedullary ...
Mohammed Nuru‐Deen Fuseini, John G. G. Banin, Suabir Sulemana   +2 more
wiley   +1 more source

PATTERN OF THALASSEMIAS AND OTHER HEMOGLOBINOPATHIES: A STUDY IN DISTRICT DERA ISMAIL KHAN, PAKISTAN

Gomal Journal of Medical Sciences, 2014
Background: Thalassemia is used to describe disorders with a significant decrease in the rate of synthesis of a globin chain. The term hemoglobinopathy is used to indicate those disorders with structurally abnormal hemoglobin.
Javaid Hussain, Sara Arif, Sher Zamir, Mohammad Amin Jan Mahsud, Shah Jahan   +4 more
doaj  

Transformed but Not Cured: The Ethics of Describing Gene‐Editing Therapy for Sickle Cell Disease

Hastings Center Report, Volume 56, Issue 3, Page 9-14, May–June 2026.
Abstract In December 2023, the U.S. Food and Drug Administration approved gene‐editing therapies as sickle cell disease treatments. Such approvals for gene‐editing not only mark radical scientific innovations for populations living with sickle cell disease (SCD) across the United States but also generate an expectation of a potential cure—the end or ...
Jada Wiggleton‐Little, Shameka Poetry Thomas, Kristin Walters, Consuela Albright   +3 more
wiley   +1 more source

Anemia Among Hospitalized Children in a Ghanaian Pediatric Emergency Unit: A Prospective Observational Study of Prevalence, Associated Factors, and Hematologic Patterns

Health Science Reports, Volume 9, Issue 5, May 2026.
ABSTRACT Background and Aims Anemia remains a major contributor to pediatric morbidity and mortality in sub‐Saharan Africa, yet contemporary data from tertiary pediatric emergency settings are limited, particularly among children older than 5 years. This study assessed the prevalence, factors associated with anemia, hematological characteristics, and ...
Serwah Bonsu Asafo‐Agyei, Emmanuel Ameyaw, Samuel Blay Nguah, Vivian Paintsil, Akua Afriyie Ocran   +4 more
wiley   +1 more source

The impact of low‐dose aspirin on hemoglobin levels in pregnancy: A secondary analysis of a randomized controlled trial for prevention of hypertensive disorders of pregnancy

International Journal of Gynecology &Obstetrics, Volume 173, Issue 2, Page 982-988, May 2026.
Abstract Objectives This study evaluates the association of low‐dose aspirin (LDA) with hemoglobin (Hb) levels during pregnancy and explores how changes in Hb levels relate to hypertensive disorders of pregnancy (HDP). Methods This secondary analysis of a randomized controlled trial comprised 249 pregnant women recruited from a regional hospital in ...
N. M. Ngcobo, V. Dorsamy, C. Bagwandeen, P. Z. Mkhize, J. Moodley   +4 more
wiley   +1 more source