Results 141 to 150 of about 204,284 (266)
Health Science Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Sickle cell anemia (SCA) may influence malaria susceptibility and clinical outcomes in endemic regions. However, the interaction between hemoglobin genotypes and malaria severity remain poorly defined in endemic African settings, particulary in Angola, where SCA and malaria impose a substantial public health burden.
Cruz S. Sebastião +3 more
wiley +1 more source
Genotypes of sickle cell disease
, 2013 In this chapter, we will discuss the genotypes and phenotypes associated with the sickle syndromes. There are four major genotypes for sickle diseases, including sickle cell trait, sickle cell anemia, and compound sickle-cell-beta-thalassemia and sickle ...
Perea-Diaz, F.J., Ibarra-Cortes, B.
core +1 more source
Cerebral Blood Transit in Sickle Cell Anemia. [PDF]
J Magn Reson ImagingABSTRACT Background Sickle cell anemia (SCA) patients upregulate cerebral blood flow to compensate for decreased arterial oxygen content. Such hyperemic conditions can manifest as venous hyperintense signal on arterial spin labeling (ASL) MRI, which may reflect faster capillary blood transit, altered oxygen extraction fraction (OEF), and infarct risk ...
Richerson WT +10 more
europepmc +2 more sources
Association of Three HIF‐1α Genotypes With Susceptibility and Severity of Chronic Kidney Disease
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Hypoxic signaling is a critical factor in the pathogenesis of Chronic Kidney Disease (CKD). Hypoxia‐Inducible Factor 1 (HIF‐1) is a transcription factor that is highly expressed in the kidney and is associated with renal tubular hypoxic adaptation. Variation in the HIF‐1α subunit gene has been associated with renal pathologies.
Hanifa Aktar +3 more
wiley +1 more source
Journal of Indian Society of Pedodontics and Preventive Dentistry, 2007 Sickle cell disease (SCD) is a genetically derived disorder characterized by the presence of an abnormal hemoglobin molecule, designated as hemoglobin S (HbS).
Ramakrishna Y
doaj
European Journal of Haematology, Volume 117, Issue 4, Page 1052-1060, October 2026.ABSTRACT Background Sickle cell disease (SCD) is a chronic and life‐limiting hemoglobin and systemic vascular disease. While over 1000 people have undergone hematopoietic cell transplantation (HCT) over the last 40 years, long‐term disease‐specific and health‐related quality of life data are lacking.
Gregory M. T. Guilcher +20 more
wiley +1 more source
Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge +6 more
wiley +1 more source
Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte +5 more
wiley +1 more source
Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance
Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
Dunia Hatabah +5 more
wiley +1 more source