Results 131 to 140 of about 29,542 (277)

Michael Acceptor Compounds as Hemoglobin Oxygen Affinity Modulators for Reversing Sickling of Red Blood Cells

Pharmaceuticals
Background/Objectives: Sickle cell disease (SCD) is caused by a β-globin gene mutation (βGlu6Val) that produces sickle hemoglobin (HbS). When deoxygenated, HbS polymerizes, leading to red blood cell (RBC) sickling; therefore, hemoglobin is a central ...
Khadijah A. Mohammad, Asala H. Naghi, Mohini S. Ghatge, Benita Balogun, Mariana Macias, Salma Roland, Albert Opare, Osheiza Abdulmalik, Martin K. Safo, Abdelsattar M. Omar, Moustafa E. El-Araby   +10 more
doaj   +1 more source

Redefining the role of the transfusion medicine physician in the era of advanced cellular therapies

Transfusion, EarlyView.
Eric A. Gehrie, Kevin J. Land
wiley   +1 more source

Supporting Children With a Chronic Disease and Their Parents When Admitted to Hospital: A Scoping Review of Psychosocial Supports

Acta Paediatrica, Volume 115, Issue 7, Page 1322-1372, July 2026.
Importance of psychosocial support. ABSTRACT Aim The aim of this scoping review was to identify, examine, and summarize available evidence regarding psychosocial supports provided to children with a chronic disease when admitted to hospital and their parents. Method The JBI methodology for conducting and reporting scoping reviews was followed.
Lyndsay Jerusha MacKay, Nolan Lagrisolal, Una Chang, Matthew Christoffersen, K. Alix Hayden, Kathryn Birnie, Tammie Dewan   +6 more
wiley   +1 more source

Longitudinal Analysis of Sleep‐Disordered Breathing and Cognitive Outcomes in Children Living With Sickle Cell Anaemia

Clinical Otolaryngology, Volume 51, Issue 4, Page 520-528, July 2026.
ABSTRACT Objectives Sleep‐disordered breathing (SDB) and cognitive challenges are commonly observed in children living with sickle cell anaemia (SCA). This study investigated the longitudinal change in polysomnographic outcomes and the association with cognitive functions in children living with SCA.
Shifa Hamdule, Melanie Koelbel, Johanna C. Gavlak, Sati Sahota, Fenella J. Kirkham, Anna M. Hood   +5 more
wiley   +1 more source

Academic and cerebrovascular outcomes after neurodevelopmental screening in sickle cell disease: A longitudinal cohort study

Developmental Medicine &Child Neurology, Volume 68, Issue 7, Page 916-924, July 2026.
Neurodevelopmental screening in toddlers or preschoolers with sickle cell disease (SCD) predicts future academic deficits. Screening sensitivity for future academic deficits is highest in preschoolers with SCD. Brief neurodevelopmental screening tools can identify high risk children for early intervention. This original article is commented on by Karst
Sarah E. Bills, Jeffrey Schatz, Elizabeth Gillooly, Julia D. Johnston, A. Lauren Waters, Alyssa M. Schlenz   +5 more
wiley   +1 more source

Diagnostic patterns of haemoglobinopathies: A prospective observational study using high-performance liquid chromatography in a remote tertiary care center of Telangana.

Student's Journal of Health Research Africa
Background Haemoglobinopathies, including sickle cell disorders and thalassemias, are significant genetic conditions that alter hemoglobin structure and function.
Dr. Sumayya , Dr . Charitha Sravanthi Battu, Dr . K Raja Kumar   +2 more
doaj   +1 more source

Patient‐Reported Outcomes With Luspatercept Through 5 Years of Treatment in Patients With Non‐Transfusion‐Dependent β‐Thalassemia Treated in the BEYOND Trial

European Journal of Haematology, Volume 117, Issue 1, Page 161-173, July 2026.
ABSTRACT In the phase 2, double‐blind, randomized controlled BEYOND trial (NCT03342404), luspatercept increased hemoglobin levels in patients with non‐transfusion‐dependent β‐thalassemia (NTDT). This study assessed long‐term effects of luspatercept on patient‐reported outcomes (PROs), using data from BEYOND and patients who continued luspatercept ...
Khaled M. Musallam, Maria Domenica Cappellini, Antonis Kattamis, Matthew Dyer, Ahmed Hnoosh, Laurie Eliason, Christopher G. Pelligra, Shien Guo, Yutian Mu, Loyse Felber Medlin, Marta Reverte, Kevin H. M. Kuo, Ali T. Taher   +12 more
wiley   +1 more source

Impact of Breath Holding on Spleen Stiffness Measured by 100 Hz Vibration Controlled Transient Elastography

Liver International, Volume 46, Issue 7, July 2026.
ABSTRACT Backgrounds and Aims Ultrasound‐based spleen stiffness measurement (SSM) is a valid non‐invasive tool to assess portal hypertension (PH) in chronic liver disease. Whereas the role of the respiratory phase during liver stiffness measurements is established, no study has specifically addressed how respiration influences SSM by transient ...
Sebastiana Atzori, Pierluigi Meloni, Marco Arru, Gianpaolo Vidili   +3 more
wiley   +1 more source

A microrheological study of sickle hemoglobin polymerization [PDF]

, 2009
Sickle hemoglobin (HbS) is a genetic alteration of normal hemoglobin A (HbA). In HbS, a surface amino acid (b6) is transformed from charged (Glu) to hydrophobic (Val).
Zakharov, Mikhail N.
core  

Influence of sickle hemoglobin polymerization and membrane properties on deformability of sickle erythrocytes in the microcirculation

, 1992
The rheological properties of normal erythrocytes appear to be largely determined by those of the red cell membrane. In sickle cell disease, the intracellular polymerization of sickle hemoglobin upon deoxygenation leads to a marked increase in ...
Chadwick, R.S., Schechter, A.N., Dong, C.   +2 more
core   +1 more source