Results 11 to 20 of about 35 (34)

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Reproductive functions and fertility preservation in men with sickle cell disease

Andrology, EarlyView.
Abstract Background Sickle cell disease (SCD) is a prevalent hereditary disorder with significant morbidity, including potential impacts on male fertility. This study aims to evaluate the semen parameters in men with SCD and assess the outcomes of fertility preservation strategies.
Clarisse Leblanc, Nathalie Sermondade, Diane Rivet‐Danon, Ludmilla Aworet‐Ogouma, Anna Ly, Guillaume Bachelot, Françoise Lionnet, Aline Santin, Anne‐Gael Cordier, Kamila Kolanska, Rachel Lévy, Isabelle Berthaut, Charlotte Dupont   +12 more
wiley   +1 more source

The wider perspective: Barriers and recommendations for transfusion support for patients with sickle cell disease in low‐ and middle‐income countries

British Journal of Haematology, EarlyView.
Globally, sickle cell disease (SCD) is the most common inherited haemoglobinopathy. The highest burden of SCD is encountered in low‐ and middle‐income countries (LMICs), most of which lack the resources to contend with the disease. Blood transfusion remains central to the emergent treatment and prevention of complications of SCD.
Jeremy W. Jacobs, Luiz Amorim, France Pirenne, Claude Tayou, Ijele Adimora, Lydia H. Pecker, Aaron A. R. Tobian, Jeannie Callum, Julie Makani, Mark T. Gladwin, Meghan Delaney, Darrell J. Triulzi, Isaac Odame, Evan M. Bloch   +13 more
wiley   +1 more source

Underlying disease is the main risk factor in post‐splenectomy complication risk: Data from a national database

British Journal of Haematology, EarlyView.
The association between underlying haematological disease, age at splenectomy and post‐splenectomy complications was explored among 1348 splenectomized patients, followed in 53 clinical centres with a median follow‐up time of 13 years and affected by transfusion‐dependent thalassaemia (TDT), non‐transfusion‐dependent thalassaemia (NTDT), sickle cell ...
Maddalena Casale, Raffaella Colombatti, Manuela Balocco, Paola Corti, Susanna Barella, Giovanna Graziadei, Loredana Farinasso, Tommaso Mina, Simone Cesaro, Tommaso Casini, Fiorina Giona, Saverio Ladogana, Pellegrina Pugliese, Lucia Dora Notarangelo, Antonella Sau, Simone Ferrero, Giovanni Palazzi, Giovanna Russo, Ilaria Lazzareschi, Marilena Serra, Saveria Campisi, Gianluca Boscarol, Elena Facchini, Carlo Baronci, Maria Caterina Putti, Domenico Roberti, Marzia Manilia, Antonio Ivan Lazzarino, Gian Luca Forni, Silverio Perrotta, on behalf of the Italian Network of Asplenia, Piero Farruggia, Francesca Fioredda, Paola Giordano, Federico Verzegnassi, Maria Luisa Casciana, Assunta Tornesello, Ilaria Capolsini, Paolo Grotto, Paola Maria Grazia Sanna, Luciana Rigoli, Rosanna Di Concilio, Flavia Rivellini, Annamaria Pansanisi, Gloria Colarusso   +44 more
wiley   +1 more source

The Impact of Allogeneic Hematopoietic Stem Cell Transplantation on Sickle Cell Retinopathy and Maculopathy: A Prospective, Observational Study

American Journal of Hematology, EarlyView.
Rajani P. Brandsen, Elisabeth Dovern, Bart J. Biemond, Roselie M. H. Diederen, Erfan Nur   +4 more
wiley   +1 more source

The role of red blood cell characteristics and viscosity in sickle cell retinopathy and maculopathy

British Journal of Haematology, EarlyView.
Sickle cell retinopathy and maculopathy are common ocular complications of sickle cell disease. This study assessed the contribution of red blood cell characteristics and blood viscosity to their development. HbSC patients with proliferative retinopathy showed a lower delta elongation index and point of sickling, while no link was found between whole ...
Rajani P. Brandsen, Roselie M. H. Diederen, Ingeborg Klaassen, Martijn Veldthuis, Herbert Korsten, Rob van Zwieten, Reinier O. Schlingemann, Erfan Nur, Bart J. Biemond   +8 more
wiley   +1 more source

Risk factors for immediate postpartum sickle cell disease‐specific maternal morbidity

British Journal of Haematology, EarlyView.
A hypothetical model describing the associations found in the analysis of factors contributing to the postpartum composite outcome. Risk factors in yellow boxes were significant only in univariate analysis; risk factors in green boxes were significant in multivariable analysis. Created with biorender.com.
Joanna Loh, Kevin H. M. Kuo, Ilinca Georgescu, Stella Wang, Ella Huszti, Nadine Shehata, A. Kinga Malinowski   +6 more
wiley   +1 more source

Glycated albumin and fructosamine do not improve accuracy of glycaemic control assessment in patients with conditions reported to affect HbA1c reliability

Diabetic Medicine, EarlyView.
Abstract Aims HbA1c testing in African populations may be limited due to high prevalence of hemoglobinopathies, anaemia, malaria and renal impairment. We aimed to assess the performance of glycated albumin (GA) and fructosamine in comparison to HbA1c for determining glycaemic control in Africans living with type 2 diabetes.
Anxious J. Niwaha, Priscilla A. Balungi, Timothy J. McDonald, Andrew T. Hattersley, Beverley M. Shields, Moffat J. Nyirenda, Angus G. Jones   +6 more
wiley   +1 more source

Trends in prevalence of anaemia among people living with HIV in the UK: 20 cross‐sectional analyses using population‐based electronic primary healthcare records

HIV Medicine, EarlyView.
Abstract Background People living with HIV have a greater prevalence of anaemia compared with people without HIV, which increases the risk of associated morbidity and premature mortality. Risk factors for anaemia among people living with HIV have changed in recent decades due to new antiretroviral therapy (ART), increased uptake of ART and increasing ...
George B. Freer, Jennifer Cooper, Krishnarajah Nirantharakumar, G. Neil Thomas, Tiffany E. Gooden   +4 more
wiley   +1 more source

The Diagnostic Performance of a Sysmex XN‐31 Automated Malaria Analyzer vs. Expert Microscopy

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Malaria is a common and life‐threatening infection. Malaria diagnosis needs to be fast and reliable. Although malaria microscopy is currently the gold standard, it is laborious, requires extensive training, and relies heavily on the proficiency of microscopists.
S. Onsongo, K. Otieno, L. Mathenge, E. Makotsi, G. Kariuki, V. Ngetich, G. Muriithi, A. T. Harrison, T. Odawo, S. Kariuki   +9 more
wiley   +1 more source