Results 11 to 20 of about 398,944 (237)

Thermal properties of normal and sickled hemoglobin protein

Bibechana, 2021
Thermodynamic properties of sickled and normal hemoglobin protein are considered within the framework of classical molecular dynamics. Here we have studied the specific heat capacity and RMSD (Root Mean Square Deviation) of both types of hemoglobin ...
Jhulan Powrel, Narayan P Adhikari
doaj   +3 more sources

Fetal Hemoglobin in Sickle Hemoglobinopathies: High HbF Genotypes and Phenotypes

Journal of Clinical Medicine, 2020
Fetal hemoglobin (HbF) usually consists of 4 to 10% of total hemoglobin in adults of African descent with sickle cell anemia. Rarely, their HbF levels reach more than 30%.
M. Steinberg
semanticscholar   +1 more source

Case report: Safety and efficacy of voxelotor in a patient with sickle cell disease and stage IV chronic kidney disease

Frontiers in Medicine, 2022
Sickle cell disease (SCD) is a heterogeneous group of inherited disorders characterized by the production of sickle hemoglobin which is less soluble than an adult or fetal hemoglobin.
Awni Alshurafa, Mohamed A. Yassin
doaj   +1 more source

Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance The root cause of pathology in sickle cell disease is the polymerization of the mutant hemoglobin S upon deoxygenation in the tissues to form fibers.
E. Henry, Troy Cellmer, Emily B. Dunkelberger, B. Metaferia, J. Hofrichter, Quan Li, D. Ostrowski, R. Ghirlando, J. Louis, S. Moutéreau, F. Galactéros, S. Thein, P. Bartolucci, W. Eaton   +13 more
semanticscholar   +1 more source

Blame It on My (Arterial) Youth: How Childhood Vascular Morphology Shapes the Risk of Cerebral Vasculopathy in Sickle Cell Disease. [PDF]

Am J Hematol
American Journal of Hematology, Volume 101, Issue 3, Page 415-417, March 2026.
Pincez T.
europepmc   +2 more sources

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.

Journal of Medicinal Chemistry, 2020
Sickle cell disease (SCD) is a genetic disorder caused by a single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in sickled hemoglobin (HbS).
A. Gopalsamy, Ann E. Aulabaugh, Amey Barakat, Kevin C. Beaumont, Shawn Cabral, Daniel P. Canterbury, A. Casimiro-Garcia, Jeanne S Chang, Ming Z. Chen, Chulho Choi, Robert L. Dow, O. Fadeyi, Xidong Feng, Scott P. France, Roger M. Howard, Jay M. Janz, Jayasankar Jasti, R. Jasuja, Lyn H. Jones, Amanda J. King-Ahmad, Kelly M Knee, J. Kohrt, C. Limberakis, S. Liras, Carlos A Martinez, Kim F. McClure, A. Narayanan, J. Narula, Jonathan J. Novak, Thomas N. O’Connell, Mihir D. Parikh, D. Piotrowski, O. Plotnikova, Ralph P. Robinson, P. Sahasrabudhe, Raman K. Sharma, B. Thuma, Dipy M. Vasa, Liuqing Wei, A. Zane Wenzel, J. Withka, Jun Xiao, Hatice G Yayla   +42 more
semanticscholar   +1 more source

Candidate sequence variants and fetal hemoglobin in children with sickle cell disease treated with hydroxyurea. [PDF]

PLoS ONE, 2013
Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease,
Nancy S Green, Katherine L Ender, Farzana Pashankar, Catherine Driscoll, Patricia J Giardina, Craig A Mullen, Lorraine N Clark, Deepa Manwani, Jennifer Crotty, Sergey Kisselev, Kathleen A Neville, Carolyn Hoppe, Sandra Barral   +12 more
doaj   +1 more source

Hematologic and hemorheological determinants of resting and exercise-induced hemoglobin oxygen desaturation in children with sickle cell disease

Haematologica, 2013
The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz, Marc Romana, Marie-Laure Lalanne-Mistrih, Roberto F. Machado, Yann Lamarre, Vanessa Tarer, Marie-Dominique Hardy-Dessources, Benoît Tressières, Lydia Divialle-Doumdo, Marie Petras, Frederic Maillard, Maryse Etienne-Julan, Philippe Connes   +12 more
doaj   +1 more source

Study on HemoTypeSC™ test for the rapid screening of sickle cell disease patients in Government Medical College and Hospital, Ambikapur

Asian Journal of Medical Sciences, 2022
Background: Sickle cell disease (SCD), also known as sickle cell anemia, is a dangerous disease in which the body produces an abnormal form of hemoglobin, the protein in red blood cells that transport oxygen throughout the body. The body produces sickle-
Salma Mahaboob R , Obulesu G , Rajesh Kumar Srivastava , Murthy R , Parmanand Agarwal , Arya R C   +5 more
doaj   +1 more source

Perspective: A novel prognostic for sickle cell disease

Saudi Journal of Medicine and Medical Sciences, 2018
Sickle hemoglobin (α2βS2) polymerization drives disease pathophysiology in sickle cell anemia. Fetal hemoglobin (α2γ2) restricts disease severity by inhibiting the polymerization of sickle hemoglobin in a concentration-dependent manner. Clinical decision-
Brian M Mozeleski, Abdullah Al-Rubaish, Amein Al-Ali, Jose Romero   +3 more
doaj   +1 more source