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The interactions of sickle hemoglobin
Biochimie, 1972Resume Les interactions entre molecules d'hemoglobine qui conduisent a la falciformation des erythrocytes, aux crises micro-emboliques et a l'anemie chronique sont dues a la presence de la desoxyhemoglobine S (α 2 a β 2 6Val ). Au cours de la desoxygenation la viscosite des solutions concentrees d'hemoglobine S augmente progressivement; il y a ...
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The oxygen affinity of sickle hemoglobin
Respiratory Physiology & Neurobiology, 2008The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (S(o)(2)), even when oxygen partial pressure (P(o)(2)) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal.
Amgad, Abdu +2 more
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The spectrum of sickle hemoglobin-related nephropathy: from sickle cell disease to sickle trait
Expert Review of Hematology, 2017 Renal dysfunction is among the most common complication of sickle cell disease (SCD), from hyposthenuria in children to progression to overt chronic kidney disease (CKD) in young adults.
Rakhi P Naik, Vimal K Derebail
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Fetal Hemoglobin, Sickling, and Sickle Cell Disease
Advances in Pediatrics, 1990Increased numbers of F cells and large amounts of Hb F/F cell appear to produce clinical benefit in rare variants of sickle cell disease and probably in more commonly encountered patients. Fetal hemoglobin interferes with polymerization of Hb S in vitro, but laboratory studies carried out with homogeneous hemoglobin solutions are inadequate models of ...
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Sickle Cell Hemoglobin Polymerization
1990Publisher Summary The chapter describes the understanding of the physics and physical chemistry of sickle cell hemoglobin polymerization in solutions and in red cells. The polymerization of sickle cell hemoglobin has probably become the best understood of all protein self-assembly systems.
W A, Eaton, J, Hofrichter
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Fetal hemoglobin in sickle cell anemia
Blood, 2011 Fetal hemoglobin (HbF) is the major genetic modulator of the hematologic and clinical features of sickle cell disease, an effect mediated by its exclusion from the sickle hemoglobin polymer. Fetal hemoglobin genes are genetically regulated, and the level
Abdulrahman Alsultan +2 more
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A Novel Sickle Hemoglobin: Hemoglobin S-South End
Journal of Pediatric Hematology/Oncology, 2004Sickle hemoglobin (Hb S; beta Glu6Val) is due to an AGTG; beta Lys132Asn, AAA>AAC). When present alone, the beta Lys132Asn mutation has low oxygen affinity. Therefore, this mutation may enhance the polymerization of the Hb S variant. Furthermore, the variant hemoglobin mimics Hb A on high-pressure liquid chromatography, and its identity is not easily ...
Hong-Yuan, Luo +7 more
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Plasma Hemoglobin and Hemoglobin Fractions in Sickle Cell Crisis
American Journal of Clinical Pathology, 1971The geometric mean of plasma hemoglobin concentrations assayed by a modified benzidine procedure in 14 patients with sickle cell anemia (S-S hemoglobin) during 18 painful crises was 8.5 mg. per 100 ml. as compared with 5.9 mg. per 100 ml. during quiescent periods and 0.3 mg. per 100 ml. in normal controls. On the first and second days of crisis, plasma
H N, Naumann +3 more
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Oxygen binding to sickle cell hemoglobin
Journal of Molecular Biology, 1979Abstract The extent of oxygen binding and light scattering of concentrated solutions of hemoglobin S have been determined as a function of oxygen partial pressure using a thin film optical cell. Nearly reversible oxygen binding is observed as witnessed by the small hysteresis found between slow deoxygenation and reoxygenation runs.
S J, Gill +4 more
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The Neurotoxic Effect of Sickle Cell Hemoglobin
Free Radical Research, 2004A growing body of experimental evidence suggests that the oxidative neurotoxicity of hemoglobin A may contribute to neuronal loss after CNS hemorrhage. Several hemoglobin variants, including hemoglobin S, are more potent oxidants in cell-free systems.
Garig M, Vanderveldt, Raymond F, Regan
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