Results 241 to 250 of about 29,542 (277)
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Interactions of Other Hemoglobin Variants with Sickle-Cell Hemoglobin
New England Journal of Medicine, 1970Deoxygenation-induced sickling of erythrocytes and gelling of hemolysates containing sickle-cell hemoglobin (Hb) are manifestations of the tendency of deoxyhemoglobin S in concentrated solutions to aggregate with the formation of gels or tactoids (liquid crystals).
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The oxygen equilibrium of sickle-cell hemoglobin
Biochimica et Biophysica Acta, 1961Abstract The equilibria between oxygen and normal and sickle-cell hemoglobins have been redetermined. Sickle-cell hemoglobin has a considerably lower affinity for oxygen than normal. At low concentrations the oxygen pressure at which sickle-cell hemoglobin is half oxygenated is 26–39% higher than in normal hemoglobin.
A, RIGGS, M, WELLS
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A New Hemoglobin Variant with Sickling Properties
New England Journal of Medicine, 1963THE red-cell sickling tendency of certain persons has long been a matter of great interest. Study of this problem by Pauling and his associates1 led to the suggestion of a genetic change in hemoglobin formation that resulted in synthesis of different globin fractions for normal and sickle-cell hemoglobin.
L E, PIERCE, C E, RATH, K, McCOY
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Ultrastructural Features of Erythrocyte and Hemoglobin Sickling
Archives of Internal Medicine, 1974Hemoglobin polymerization develops from a process of condensation, molecular interaction, aggregation, and assembly. Molecular organization of structures formed during polymerization depends on the type of hemoglobin, its specific defect, and its state of oxygenation. Sickling exemplifies hemoglobin polymerization.
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Stereospecific Inhibitors of the Gelation of Sickle Hemoglobin
Hemoglobin, 1980During the last decade there have been major advances in understanding the structure of the gel of deoxyhemoglobin S and the mechanism of its formation. These advances have allowed the development of a new strategy for the inhibition of gelation, i.e., stereospecific competitive inhibitors of the polymerization process.
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Screening for sickle hemoglobin??? a review
The American Journal of the Medical Sciences, 1973D W, Westring, S, Grand
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Neonatal Screening for Sickle Hemoglobin
American Journal of Clinical Pathology, 1979G, Serjeant, B, Serjeant
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Sickle Cell Anemia and Fetal Hemoglobin
The American Journal of the Medical Sciences, 1994Fetal hemoglobin, the predominant hemoglobin of the fetus, is good for sickle cell anemia. This hemoglobin inhibits the polymerization of sickle hemoglobin. Clinical studies have shown that at any level of fetal hemoglobin, the more that is present, the better off is the patient.
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Filter failures with sickling hemoglobin
Transfusion, 2009Eapen K, Jacob +4 more
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