Results 31 to 40 of about 1,338,396 (378)

In vitro determination of hemoglobin A1c for diabetes diagnosis and management: technology update [PDF]

, 2014
It is fascinating to consider the analytical improvements that have occurred since glycated hemoglobin was first used in routine clinical laboratories for diabetes monitoring around 1977; at that time methods displayed poor precision, there were no ...
English, Emma, John, W Garry, Milosevich, Elise T   +2 more
core   +1 more source

Cross-sectional and longitudinal association between hemoglobin concentration and hypertension

Medicine, 2016
We investigated the cross-sectional and longitudinal associations between hemoglobin concentration and hypertension in a Korean population. Between 2006 and 2013, we examined 4899 participants with mean age of 56.6 years (range 35–88 years) from a rural ...
Na Hyun Kim, Ju-Mi Lee, H. Kim, J. Lee, Hyungseon Yeom, J. H. Lee, I. Suh   +6 more
semanticscholar   +1 more source

The primary structure of three hemoglobin chains from the indigo snake (Drymarchon corais erebennus, Serpentes): First evidence for αD chains and two β chain types in snakes [PDF]

, 2002
The hemoglobin of the indigo snake (Drymarchon corais erebennus, Colubrinae) consists of two components, HbA and HbD, in the ratio of 1:1. They differ in both their alpha and beta chains.
Abbasi A., Abbasi A., Begg G., Bonilla G.O., Braunitzer G., Brown J.L., Cadle J.E., Chapman B.S., De Smet W.H.O., Focesi, Focesi, Friedman M., Fushitani K., Hewick R.M., Hiebl I., Kleinschmidt T., Lottspeich F., Matsuura M.S.A., Matsuura M.S.A., Naqui S., Oberthuer W., Oyama S. Jr., Ruecknagel K.P.   +22 more
core   +1 more source

Hemoglobin and anemia in relation to dementia risk and accompanying changes on brain MRI

Neurology, 2019
Objective To determine the long-term association of hemoglobin levels and anemia with risk of dementia, and explore underlying substrates on brain MRI in the general population.
PhD Frank J. Wolters, MD Hazel I. Zonneveld, MD Silvan Licher, PhD Lotte G.M. Cremers, PhD Peter J. Koudstaal, PhD Meike W. Vernooij, PhD M. Arfan Ikram, Erasmus Medical, L. Kappelle, A. Rossum, Mat J.A.P. Daemen   +10 more
semanticscholar   +1 more source

MR imaging–derived oxygen-hemoglobin dissociation curves and fetal-placental oxygen-hemoglobin affinities [PDF]

, 2016
PURPOSE: To generate magnetic resonance (MR) imaging–derived, oxygen-hemoglobin dissociation curves and to map fetal-placental oxygen-hemoglobin affinity in pregnant mice noninvasively by combining blood oxygen level–dependent (BOLD) T2* and oxygen ...
Akselrod-Ballin, Ayelet, Avni, Reut, Biton, Inbal, Cohen, Yonni, Garbow, Joel R, Golani, Ofra, Neeman, Michael   +6 more
core   +2 more sources

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells

Science, 2018
A CRISPR screen for RBC regulators Hemoglobin in red blood cells (RBCs) carries oxygen to the tissues. Sickle cell disease is an inherited condition that involves abnormal hemoglobin.
Jeremy D. Grevet, Xianjiang Lan, Nicole Hamagami, Christopher R. Edwards, Laavanya Sankaranarayanan, X. Ji, Saurabh K. Bhardwaj, Carolyne J. Face, D. Posocco, O. Abdulmalik, C. Keller, B. Giardine, Simone Sidoli, B. A. Garcia, S. Chou, S. Liebhaber, R. Hardison, Junwei Shi, G. Blobel   +18 more
semanticscholar   +1 more source

Hemoglobin I: An Inherited Hemoglobin Anomaly [PDF]

Blood, 1955
Abstract A hitherto undescribed hemoglobin anomaly has been detected in a North Carolina Negro family. This new hemoglobin, designated type I, which has been electrophoretically characterized, was found in combination with normal adult A hemoglobin in 6 of 17 members of one family.
D. L. Rucknagel, W. N. Jensen, E. B. Page   +2 more
openaire   +3 more sources

Effect of liganded hemoglobin S and hemoglobin A on the aggregation of deoxy-hemoglobin S.

Journal of Biological Chemistry, 1982
The effect of the carbonmonoxy forms of Hb S and Hb A on the solubility and kinetics of the aggregation of deoxy-Hb S in concentrated phosphate buffer was studied. The delay time was prolonged exponentially when the ratios of CO-Hb S and CO-Hb A to deoxy-Hb S were increased.
K Adachi, T Asakura
openaire   +3 more sources

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin

ACS Medicinal Chemistry Letters, 2017
We report the discovery of a new potent allosteric effector of sickle cell hemoglobin, GBT440 (36), that increases the affinity of hemoglobin for oxygen and consequently inhibits its polymerization when subjected to hypoxic conditions.
B. Metcalf, Chihyuan Chuang, K. Dufu, Mira P Patel, Abel Silva-García, C. Johnson, Qing Lu, J. Partridge, L. Patskovska, Y. Patskovsky, S. Almo, M. Jacobson, Lan Hua, Qing Xu, S. L. Gwaltney, C. Yee, Jason Harris, B. Morgan, Joyce K James, Donghong Xu, A. Hutchaleelaha, K. Paulvannan, D. Oksenberg, Zhe Li   +23 more
semanticscholar   +1 more source

Association of Hemoglobin Concentration and Its Change With Cardiovascular and All‐Cause Mortality

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2018
Background Anemia is thought to increase mortality risks, but the effects of high hemoglobin concentration on survival are unclear. The effect of change in hemoglobin concentrations on survival in the general population is also unknown.
Gyeongsil Lee, Seulggie Choi, Kyuwoong Kim, J. Yun, J. Son, Su-Min Jeong, Sung Min Kim, Sang Min Park   +7 more
semanticscholar   +1 more source