Results 51 to 60 of about 827,803 (310)

Exogenous erythropoietin increases hematological status, fat oxidation, and aerobic performance in males following prolonged strenuous training

Physiological Reports
This study investigated the effects of EPO on hemoglobin (Hgb) and hematocrit (Hct), time trial (TT) performance, substrate oxidation, and skeletal muscle phenotype throughout 28 days of strenuous exercise.
Devin J. Drummer, Julie L. McNiff, Emily E. Howard, Jess A. Gwin, Christopher T. Carrigan, Nancy E. Murphy, Marques A. Wilson, Julia Michalak, Benjamin J. Ryan, James P. McClung, Stefan M. Pasiakos, Lee M. Margolis   +11 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Structural and functional studies of hemoproteins from polar marine organisms [PDF]

, 2011
Antarctica, more than any other habitat on Earth, represents a unique natural laboratory for fundamental research on the processes that have produced biological diversity in extreme environments and, at the same time, offers potential biotechnological ...
Coppola, Daniela
core   +1 more source

High Levels Of Human γ-globin Are Expressed In Adult Mice Carrying A Transgene Of The Brazilian Type Of Hereditary Persistence Of Fetal Hemoglobin (aγ -195)

, 2015
Hereditary persistence of fetal hemoglobin (HPFH) is characterized by increased levels of Hb F during adult life. Nondeletional forms of HPFH are characterized by single base mutations in the Aγ and Gγ promoters, resulting in an increase of Hb F ranging ...
Da Cunha A.F., Corra Passos L.A., Costa F.F., Gimenes A.P., Saad S.T.O., Brugnerotto A.F., Barbosa De Melo M., Finzi Corat M.A., Bodine D., Devlin E.E.   +9 more
core   +1 more source

Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance

Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah, Martha E. Stewart, Nathan Maassel, James P. Stevens, Claudia R. Morris, Chris A. Rees   +5 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

The administration of sea hare gonad and moringa leaf formula increases body weight hemoglobin in female Wistar rats

Healthcare in Low-resource Settings
Sea hare gonad and moringa leaf contain essential nutrients for growth and tissue formation and have physiological effects on the body. The research was to study the effects of sea hare gonad flour and moringa leaf flour formula on body weight and ...
Wiralis Wiralis, Suwarni Suwarni, Hariani Hariani, Askrening Askrening, Nadimin Nadimin   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Low Uptake of Hydroxyurea among a Cohort of Sickle Cell Disease Patients in Nigeria

Nigerian Journal of Medicine
Background: Hydroxyurea (HU) is the first disease-modifying drug used in the treatment of sickle cell disease (SCD). Despite its well-documented benefits, adoption and drug adherence have remained difficult.
Helen Chioma Okoye, Chilota Chibuife Efobi, Hannah Ommunakwe, Augustine Nwakuche Duru, Benedict Nwogoh, Ngozi Immaculata Ugwu, Collins Maduka, Charles Emeka Nonyelu, Ikechukwu Okwudili Anigbogu, Angela Ogechukwu Ugwu   +9 more
doaj   +1 more source