Results 61 to 70 of about 772,447 (312)

Exogenous erythropoietin increases hematological status, fat oxidation, and aerobic performance in males following prolonged strenuous training

Physiological Reports
This study investigated the effects of EPO on hemoglobin (Hgb) and hematocrit (Hct), time trial (TT) performance, substrate oxidation, and skeletal muscle phenotype throughout 28 days of strenuous exercise.
Devin J. Drummer, Julie L. McNiff, Emily E. Howard, Jess A. Gwin, Christopher T. Carrigan, Nancy E. Murphy, Marques A. Wilson, Julia Michalak, Benjamin J. Ryan, James P. McClung, Stefan M. Pasiakos, Lee M. Margolis   +11 more
doaj   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

A PEGylated bovine hemoglobin as a potent hemoglobin-based oxygen carrier [PDF]

, 2017
Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been used as blood substitutes in surgery medicine and oxygen therapeutics for ischemic stroke.
Hu, Tao, You, Guoxing, Li, Penglong, Dawei Gao, Wang, Ying, Penglong Li, Tao Hu, Hong Zhou, Wang, Linli, Weili Yu, Zhang, Shan, Linli Wang, Jun Zhang, Yu, Weili, Shan Zhang, Ying Wang, Lian Zhao, Zhao, Lian, Zhou, Hong, Guoxing You, Gao, Dawei, Zhang, Jun   +21 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Fiber depolymerization [PDF]

, 2006
Depolymerization is, by definition, a crucial process in the reversible assembly of various biopolymers. It may also be an important factor in the pathology of sickle cell disease.
Turner, Matthew S., Ferrone, F.A., Agarwal, G., Wang, J.C., Jones, C. W., Kwong, S., Briehl, R. W., Briehl, R.W., Wang, J. C., Ferrone, F. A., Josephs, R., Jones, C.W., Turner, M.S.   +12 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The administration of sea hare gonad and moringa leaf formula increases body weight hemoglobin in female Wistar rats

Healthcare in Low-resource Settings
Sea hare gonad and moringa leaf contain essential nutrients for growth and tissue formation and have physiological effects on the body. The research was to study the effects of sea hare gonad flour and moringa leaf flour formula on body weight and ...
Wiralis Wiralis, Suwarni Suwarni, Hariani Hariani, Askrening Askrening, Nadimin Nadimin   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Molecular mechanism of AHSP-mediated stabilization of alpha-hemoglobin [PDF]

, 2004
Hemoglobin A (HbA), the oxygen delivery system in humans, comprises two α and two β subunits. Free α-hemoglobin (αHb) is unstable, and its precipitation contributes to the pathophysiology of β thalassemia.
David Gell (14737321), Rich, AM (15531488), Lay, PA (15531494), Kong, Y (15531413), Hu, M (15531479), Weiss, MJ (15531407), Nan, N (15531482), Lee, C (15531485), Gu, L (15531437), Li, J (15510557), Shi, Y (5802803), Armstrong, RS (15531491), Mackay, JP (15531410), Feng, L (15531395), Zhou, S (15524792), Gow, AJ (15483407)   +15 more
core  

Low Uptake of Hydroxyurea among a Cohort of Sickle Cell Disease Patients in Nigeria

Nigerian Journal of Medicine
Background: Hydroxyurea (HU) is the first disease-modifying drug used in the treatment of sickle cell disease (SCD). Despite its well-documented benefits, adoption and drug adherence have remained difficult.
Helen Chioma Okoye, Chilota Chibuife Efobi, Hannah Ommunakwe, Augustine Nwakuche Duru, Benedict Nwogoh, Ngozi Immaculata Ugwu, Collins Maduka, Charles Emeka Nonyelu, Ikechukwu Okwudili Anigbogu, Angela Ogechukwu Ugwu   +9 more
doaj   +1 more source