Results 71 to 80 of about 826,020 (365)

Can morphological changes of erythrocytes be driven by hemoglobin? [PDF]

, 2017
At 49 C erythrocytes undergo morphological changes due to an internal force, but the origin of the force that drives changes is not clear. Here we point out that our recent experiments on thermally induced force-release in hemoglobin can provide an explanation for the morphological changes of erythrocytes.
arxiv   +1 more source

Response to comment on 'Valid molecular dynamics simulations of human hemoglobin require a surprisingly large box size'

eLife, 2019
We recently reported that molecular dynamics simulations for hemoglobin require a surprisingly large box size to stabilize the T(0) state relative to R(0), as observed in experiments (El Hage et al., 2018). Gapsys and de Groot have commented on this work
Krystel El Hage, Florent Hédin, Prashant K Gupta, Markus Meuwly, Martin Karplus   +4 more
doaj   +1 more source

Complete Blood Count Parameters in Apheresis Platelet Donors According to ABO and Rh Blood Groups

Bagcilar Medical Bulletin, 2022
Objective:Data about the effects of blood groups on complete blood count parameters are limited. We aimed to examine the relationship between complete blood count parameters and ABO-Rh blood groups in this study.Method:Three thousand volunteer apheresis ...
Gülden Sincan, Fuat Erdem, Elif Bulut, Suat Sincan   +3 more
doaj   +1 more source

Updates of the HbVar database of human hemoglobin variants and thalassemia mutations

Nucleic Acids Res., 2013
HbVar (http://globin.bx.psu.edu/hbvar) is one of the oldest and most appreciated locus-specific databases launched in 2001 by a multi-center academic effort to provide timely information on the genomic alterations leading to hemoglobin variants and all ...
B. Giardine, Joseph Borg, Emmanouil Viennas, C. Pavlidis, K. Moradkhani, P. Joly, M. Bartsakoulia, C. Riemer, W. Miller, Giannis Tzimas, H. Wajcman, R. Hardison, G. Patrinos   +12 more
semanticscholar   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Whole genome sequencing of the fast-swimming Southern bluefin tuna (Thunnus maccoyii)

Frontiers in Genetics, 2022
The economically important Southern bluefin tuna (Thunnus maccoyii) is a world-famous fast-swimming fish, but its genomic information is limited. Here, we performed whole genome sequencing and assembled a draft genome for Southern bluefin tuna, aiming to
Xiaomeng Zhao, Xiaomeng Zhao, Yu Huang, Chao Bian, Xinxin You, Xinxin You, Xinhui Zhang, Xinhui Zhang, Xinhui Zhang, Jieming Chen, Min Wang, Cancan Hu, Yun Xu, Yun Xu, Yun Xu, Junmin Xu, Junmin Xu, Junmin Xu, Qiong Shi, Qiong Shi, Qiong Shi   +20 more
doaj   +1 more source

The inherited diseases of hemoglobin are an emerging global health burden.

Blood, 2010
It is estimated that in excess of 300,000 children are born each year with a severe inherited disorder of hemoglobin and that approximately 80% of these births occur in low- or middle-income countries.
D. Weatherall
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Quantum states entanglement in hemoglobin molecule active center [PDF]

, 2016
An ab initio study of the electronic and spin configuration for the iron ion in the active center of the human hemoglobin molecule is presented. It is well known that the iron ion, being surrounded by the porphyrin ring and the ligands, plays the key role in the realization of the basic oxygen-transport functions of the molecule.
arxiv   +1 more source