Results 11 to 20 of about 489,285 (241)

Hemoglobin: Modification, Crystallization, Polymerization (Review)

Общая реаниматология, 2017
The purpose of this review is to present the most significant modifications and transformations of a hemoglobin molecule potentially related to developing a strategy of resuscitation and treatment of lifethreatening forms of anemia.
V. A. Sergunova, E. A. Manchenko, O. Ye. Gudkova   +2 more
doaj   +1 more source

Fortuitous Discovery of a Heterozygous Hemoglobin S Disorder Associated with Hemoglobin G-Philadelphia S/G. A Case Report. [PDF]

Batna Journal of Medical Sciences
The coexistence of two abnormal alpha and beta hemoglobin variants in the same individual is a rare and sparsely documented situation. We report the case of a diabetic child of Algerian origin, , followed in the pediatric department for insulin ...
Ahmed KHECHIBA, Nawel KENZAOUI, Bouchra ZAGOUG, Khadidja BENALLAL   +3 more
doaj   +1 more source

Solubilization of hemoglobin S by other hemoglobins. [PDF]

Proceedings of the National Academy of Sciences, 1980
The polymerization of mixtures of Hb S with hemoglobins A, A2, and F has been investigated by analysis of the proportions of S and non-S hemoglobin both in the supernate and in the pellet after centrifugation. In all cases the non-S hemoglobin was incorporated into the polymer even in the absence of hybrids in the order A > A2 > F. The solubility
R E, Benesch, R, Edalji, R, Benesch, S, Kwong   +3 more
openaire   +2 more sources

Analysis of sickle hemoglobin

Journal of Pathology of Nepal, 2013
Background: Sickle Hemoglobin is the most common pathological hemoglobin mutation worldwide which forms sickle shape or elongated forms on deoxygenation.
A Shrestha, S Karki
doaj   +1 more source

Interaction Between Human Hemoglobin Variants and Hemoglobin S

Experimental Biology and Medicine, 1978
SummarySeven abnormal hemoglobins were investigated for an effect on the gelation of Hb S in the deoxy- or oxy-conformation. A positive effect (decreased MGC) was associated with substitution of Glu β6, Glu β26 and Glu β121. No difference was observed between the deoxy- or oxy-hemoglobins except in the case of Hb N-Baltimore which, in the deoxy state ...
J, Kumpati, T H, Hiusman, G D, Efremov
openaire   +2 more sources

ßS-Haplotypes in sickle cell anemia patients from Salvador, Bahia, Northeastern Brazil

Brazilian Journal of Medical and Biological Research, 2003
ßS-Globin haplotypes were studied in 80 (160 ßS chromosomes) sickle cell disease patients from Salvador, Brazil, a city with a large population of African origin resulting from the slave trade from Western Africa, mainly from the Bay of Benin ...
M.S. Gonçalves, G.C. Bomfim, E. Maciel, I. Cerqueira, I. Lyra, A. Zanette, G. Bomfim, E.V. Adorno, A.L. Albuquerque, A. Pontes, M.F. Dupuit, G.B. Fernandes, M.G. dos Reis   +12 more
doaj   +1 more source

Hemoglobin SE disease in Hatay, in the southern part of Turkey

Thalassemia Reports, 2015
Double heterozygosity for hemoglobin (Hb) E and S, known as HbSE disease, is a rare, clinically benign condition involving mild hemolysis. Only 25 cases have been reported to date.
Can Acipayam, Gonul Oktay, Gul Ilhan, Mehmet Akif Çürük   +3 more
doaj   +1 more source

Oxidized Mutant Human Hemoglobins S and E Induce Oxidative Stress and Bioenergetic Dysfunction in Human Pulmonary Endothelial Cells

Frontiers in Physiology, 2017
Cell free hemoglobin (Hb), becomes oxidized in the circulation during hemolytic episodes in sickle cell disease (SCD) or thalassemia and may potentially cause major complications that are damaging to the vascular system.
Sirsendu Jana, Fantao Meng, Rhoda E. Hirsch, Joel M. Friedman, Abdu I. Alayash   +4 more
doaj   +1 more source

Therapeutic red blood cell exchange in a sickle cell disease patient with acute bone pain crisis: Our experience in a tertiary care center

Asian Journal of Transfusion Science
Transfusion therapy remains the main stay of treatment for patients with sickle cell anemia for several years. However, repeated transfusions might result in iron overload and alloimmunization in sickle cell disease (SCD) patients.
Suresh Kumar Iyyapan, Hari Haran Annadurai, Gokhula Prasath Thangavel, Hemamalini Natesan   +3 more
doaj   +1 more source

Multispectral imaging for MicroChip electrophoresis enables point-of-care newborn hemoglobin variant screening

Heliyon, 2022
Hemoglobin (Hb) disorders affect nearly 7% of the world’s population. Globally, around 400,000 babies are born annually with sickle cell disease (SCD), primarily in sub-Saharan Africa where morbidity and mortality rates are high.
Ran An, Yuning Huang, Anne Rocheleau, Alireza Avanaki, Priyaleela Thota, Qiaochu Zhang, Yuncheng Man, Zoe Sekyonda, Catherine I. Segbefia, Yvonne Dei-Adomakoh, Enoch Mensah, Kwaku Ohene-Frempong, Isaac Odame, Amma Owusu-Ansah, Umut A. Gurkan   +14 more
doaj   +1 more source