The Role of Platelet-to-Neutrophil Ratio as a Biomarker for Pulmonary Hypertension in Sickle Cell Disease Patients: A Retrospective Cohort Study. [PDF]
Alwaheed AJ +12 more
europepmc +1 more source
Enhanced Intracellular Stability and Translation Efficiency of mRNA Drugs by a 2‐arm mRNA Platform
We constructed a 2‐arm mRNA, characterized by a unique topology formed through the dimerization of two mRNA 3’ tails. The 2‐arm mRNA improves 3’ tail stability and resistance to nuclease degradation, resulting in an intracellular half‐life of up to 65 h. This method substantially enhances the translation capacity of mRNA drugs.
Xucong Teng +5 more
wiley +1 more source
Elevated hemoglobin levels associated with severe sleep-disordered breathing in hemodialysis patients not receiving erythropoiesis-stimulating agents: a case series. [PDF]
Matsumoto H, Murai S.
europepmc +1 more source
Case Report: Abnormally low hemoglobin A1c in a diabetic patient with <i>SLC4A1</i> gene mutation. [PDF]
Ye L, Ren Q, Ba T, Wu J, Han X, Ji L.
europepmc +1 more source
Sickle cell disease implicated in the development of severe dengue: A pediatric case series. [PDF]
Hernández MR +3 more
europepmc +1 more source
High proportions of iron deficiency and thalassemia in blood donors with low RBC osmotic fragility: a call for targeted public health responses in Southern China. [PDF]
Sun LY +7 more
europepmc +1 more source
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Hemoglobin S, the Pneumococcus, and the Spleen
Archives of Pediatrics & Adolescent Medicine, 1972Hemoglobin S (Hb S) and selected bacteria are among medicine's more enigmatic bedfellows. The clinical importance of this association is underscored by the recognition of infection as the major presenting manifestation of sickle cell anemia in early childhood, the most common complication requiring hospitalization and the most common cause of death at ...
J. Lukens
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Surface activity of hemoglobin S and other human hemoglobin variants
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1976The kinetics of surface pressure change (deltapi vs. t isotherms) were determined for several single point mutations of the human hemoglobin system. It was observed that hemoglobin S and hemoglobin CHarlem (both containing beta6 Glu leads to Val substitutions) have a specific behavior at the water-air interface: their extent of surface pressure change ...
D, Elbaum +3 more
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A new diagnostic test for hemoglobin S
The Journal of Pediatrics, 1970Summary A differential solubility method for determining the presence of sickle hemoglobin S was investigated. The method was found to be simple and accurate, using either venous anticoagulated blood or fingerprick.
M S, Ballard +3 more
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Abstract Transverse water proton relaxation times ( T 2 ) have been measured as a function of time after deoxygenation of solutions containing hemoglobin S. The shortened T 2 values observed upon deoxygenation of hemoglobin S result from an increase in the correlation time ( τ c ) of the water fraction irrotationally bound to deoxyhemoglobin S ...
G L, Cottam +2 more
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