Results 271 to 280 of about 21,841,476 (331)

Hemoglobin S-D Disease

Annals of Internal Medicine, 1966
Excerpt Itano (1) first described hemoglobin D in 1951 in a Caucasian family who had hemoglobin S interacting with D. Hemoglobin D was the fifth hemoglobin to be described.
M J, Cawein, E J, Lappat, R W, Brangle, C H, Farley   +3 more
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A Novel Sickle Hemoglobin: Hemoglobin S-South End

Journal of Pediatric Hematology/Oncology, 2004
Sickle hemoglobin (Hb S; beta Glu6Val) is due to an AGTG; beta Lys132Asn, AAA>AAC). When present alone, the beta Lys132Asn mutation has low oxygen affinity. Therefore, this mutation may enhance the polymerization of the Hb S variant. Furthermore, the variant hemoglobin mimics Hb A on high-pressure liquid chromatography, and its identity is not easily ...
Hong-Yuan, Luo, Adeboye H, Adewoye, Shawn H, Eung, Timothy P, Skelton, Karen, Quillen, Lillian, McMahon, Martin H, Steinberg, David H K, Chui   +7 more
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Hemoglobin S-G (S-D) syndrome

The American Journal of Medicine, 1974
Abstract Two subjects are described who had positive sickle cell preparations and routine alkaline electrophoretic patterns showing only hemoglobins S, F and A 2 . Although this combination suggests sickle cell anemia, their hemoglobin separated into two major bands on agar gel electrophoresis using a citrate buffer, pH 6.2. The non-S hemoglobins were
P R, McCurdy, P A, Lorkin, R, Casey, H, Lehmann, D E, Uddin, L G, Dickson   +5 more
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Hematuria in Hemoglobin S Disorders

Archives of Internal Medicine, 1980
Medical treatment of patients with hemoglobin S disorders severely tests the skill and judgment of their physicians. Dramatic and potentially serious symptoms and findings are common; the question is whether they are primary manifestations of the hemoglobinopathy (in which case conservative management is indicated) or whether they reflect serious ...
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Oxygen equilibria of hemoglobin A and hemoglobin S valency hybrids

Archives of Biochemistry and Biophysics, 1977
Abstract Oxygen equilibrium determinations with “unsymmetrical” MetHb/Hb hybrids derived from human hemoglobins A and S are reported. All four of the possible hybrids have higher oxygen affinity than the parent hemoglobins. The α 2 Met β 2 S hybrid has a lower oxygen affinity than that of α 2 Met β 2 S .
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The oxygenation of hemoglobin A and hemoglobin S in intact erythrocytes and in aqueous solution

Biochemical Medicine, 1976
Abstract A comparative study is reported of the effect of temperature and acidity on the oxygen affinity of Hbs A and S when the Hbs are present in both intact red cells and in aqueous solution in both the presence and absence of 2,3-DPG. The reciprocal temperature plots for the oxygen affinity (expressed in terms of p50) of Hb A and Hb S stripped ...
M, Jayalakshmi, M, Seakins
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Intermolecular effects in the polymerization of hemoglobin S

Biochemical and Biophysical Research Communications, 1978
Myoglobin and isolated α and β subunits of hemoglobin A were found to have the same effect on the polymerization of hemoglobin S as intact hemoglobin A. This demonstrates that copolymerization of hemoglobins A and S need not be invoked to explain the gelling behavior of such mixtures, but that it can be adequately accounted for by the effect of the ...
R E, Benesch, R, Benesch, R, Edalji, S, Kwong   +3 more
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Carbamoylated hemoglobins A and S: physical properties

Biochemistry, 1976
Dimer-tetramer association constants (K2,4) of derivatives of CO-hemoglobins A and S specifically carbamoylated at the NH2-terminal valine residues were measured. Reactivites of the beta-93 sulfhydryls of the hemoglobin A derivatives were also investigated.
R C, Williams, H, Kim
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Length distributions of hemoglobin S fibers

Journal of Molecular Biology, 1990
Electron microscopy of sickle cell hemoglobin fibers fixed at different times during gelation shows an exponential distribution of fiber lengths, with many short fibers and few long ones. The distribution does not change significantly with time as polymerization progresses.
R W, Briehl, E S, Mann, R, Josephs
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Enhancement of S-Nitrosylation in Glycosylated Hemoglobin

Biochemical and Biophysical Research Communications, 2000
In this study, we report a novel differential nitric oxide interaction with nonglycosylated and glycosylated hemoglobin. After in vitro incubation of hemoglobin with S-nitroso N-acetyl penicillamine (SNAP), S-nitrosoglutathione, or S-nitrosocysteine, S-nitrosylation was significantly higher in human glycosylated hemoglobin purified from diabetic ...
J, Padrón, C, Peiró, E, Cercas, J L, Llergo, C F, Sánchez-Ferrer   +4 more
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