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Hemoglobin D-Punjab: origin, distribution and laboratory diagnosis
This review discusses hemoglobin D-Punjab, also known as hemoglobin D-Los Angeles, one of the most common hemoglobin variants worldwide. It is derived from a point mutation in the beta-globin gene (HBB: c.364G>C; rs33946267) prevalent in the Punjab ...
Lidiane de Souza Torres +3 more
doaj +1 more source
Effect of liganded hemoglobin S and hemoglobin A on the aggregation of deoxy-hemoglobin S.
The effect of the carbonmonoxy forms of Hb S and Hb A on the solubility and kinetics of the aggregation of deoxy-Hb S in concentrated phosphate buffer was studied. The delay time was prolonged exponentially when the ratios of CO-Hb S and CO-Hb A to deoxy-Hb S were increased.
K, Adachi, T, Asakura
openaire +2 more sources
Asymptomatic child heterozygous for hemoglobin S and hemoglobin Pôrto Alegre [PDF]
AbstractHemoglobin Pôrto Alegre (PA) is a rare hemoglobin resulting from a mutation in β9(A6)Ser → Cys. We describe an asymptomatic Puerto Rican female with combined heterozygosity for Hb PA and Hb S. Since birth, she has maintained normal hemoglobin, bilirubin, LDH levels, and reticulocyte count.
Liliana, Lojo +4 more
openaire +2 more sources
Dysbiosis by neutralizing commensal mediated inhibition of pathobionts [PDF]
Dysbiosis in the periodontal microbiota is associated with the development of periodontal diseases. Little is known about the initiation of dysbiosis.
Bernaerts, Kristel +6 more
core +3 more sources
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser +6 more
wiley +1 more source
Sickle cell disease is a hereditary disease that predominantly affects black people. It is very widespread in sub-Saharan Africa, particularly at the Lehmann “sickle belt” level, where the prevalence of the hemoglobin S involves at least 10% of the ...
Jeannette Bassimbié Kakou Danho +4 more
doaj +1 more source
Polymerization of binary mixtures of hemoglobin S and carbamylated hemoglobin S.
To study the mode of interaction between hemoglobin (Hb) S and carbamylated Hb S, the kinetics of polymerization of various mixtures of deoxy-Hb S and NH2 termini carbamylated Hb S in concentrated phosphate buffer was determined. These mixtures were found to polymerize with a clear demonstration of a delay time as does each hemoglobin in its pure form.
C Y, Ip, T, Asakura, K, Adachi
openaire +2 more sources
Hemoglobin variants with electrophoretic behavior similar to hemoglobin S [PDF]
As hemoglobinopatias são doenças genéticas relacionadas com défice da hemoglobina, a proteína vital para o transporte de oxigénio no organismo. De entre elas salienta-se a Drepanocitose causada pela variante S da hemoglobina (HbS) em homozigotia ...
Copeto, Sandra +9 more
core
Evaluation of Glycated Albumin (GA) and GA/Hba1c Ratio for Diagnosis of Diabetes and Glycemic Control: A Comprehensive Review [PDF]
Diabetes Mellitus (DM) is a group of metabolic diseases characterized by chronic high blood glucose concentrations (hyperglycemia). When it is left untreated or improperly managed, it can lead to acute complications including diabetic ketoacidosis and ...
Abdolrahim, Mojgan +6 more
core +3 more sources
Aspartic protease activities of schistosomes cleave mammalian hemoglobins in a host-specific manner
We examined the efficiency of digestion of hemoglobin from four mammalian species, human, cow, sheep, and horse by acidic extracts of mixed sex adults of Schistosoma japonicum and S. mansoni. Activity ascribable to aspartic protease(s) from S.
Jeffrey W Koehler +3 more
doaj +1 more source

