Results 131 to 140 of about 20,917 (253)

Prenatal invasive diagnostic testing for hemoglobinopathies: a retrospective cohort study at a tertiary care public hospital in central India [PDF]

Background: Transfusion-dependent hemoglobinopathies such as sickle cell disease, thalassemia, etc. have a huge impact on the Indian economy due to the need for lifelong care and treatment of associated morbidities. Primary prevention strategies focus on
Gangane, Neha, Yadav, Anita, Gupta, Avantika, Mundle, Shuchita, Davile, Medha, Dhanvij, Minal   +5 more
core   +1 more source

CRISPR/Cas9‐Mediated Correction of the SLC25A38 Mutation in a Patient With Sideroblastic Anemia

The Journal of Gene Medicine, Volume 28, Issue 10, October 2026.
In this study, the identity of fibroblast cells isolated from the patient was identified using several methods. Then, the sgRNA3‐pX459 plasmid together with ssODN was transfected into fibroblast cells with a transfection efficiency of 49.64%. Finally, the entry of ssODN donor into fibroblast cells was confirmed using PCR‐RFLP and PAGE methods. ABSTRACT
Shokoufeh Yazdanparast, Hamid Galehdari, SaeidReza Khatami, Elham Hoveizi, Kaveh Jaseb   +4 more
wiley   +1 more source

Ultrasound‐Guided Peripheral Venous Catheter for Automated Erythrocytapheresis in a Paediatric Population Affected by Sickle Cell Disease

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Introduction Automated erythrocytapheresis (aEEX) is an effective therapy for severe sickle cell disease (SCD). Its use in paediatrics can be limited by challenges in obtaining reliable venous access. Methods We conducted a retrospective, single‐centre study to evaluate the safety and feasibility of ultrasound (US)‐guided peripheral venous ...
Laura Ocello, Fabio Pavan, Giulia M. Ferrari, Fabiola Guerra, Alessandra Moretto, Elena Tassistro, Maria G. Valsecchi, Irene Lepri, Linda Gregorio, Alice Passoni, Adriana Balduzzi, Valentina Baldini, Paola Corti   +12 more
wiley   +1 more source

Ovarian Reserve in Women of Reproductive Age With Sickle Cell Anaemia: A Scoping Review

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Background Sickle cell anaemia (SCA) is an inherited haemoglobinopathy disproportionately common among people of African origin, though it affects multiple global populations. Emerging evidence suggests that chronic haemolysis, inflammation and treatment exposures in SCA may affect ovarian function.
Kehinde Awodele, Sunday Charles Adeyemo, Adeniyi Olanipekun Fasanu, John Oluwadamilola Ojo, Haruna Oche Ahmadu   +4 more
wiley   +1 more source

Assessing Prognostic Factors in Hodgkin's Lymphoma: Multistate Illness-Death Model

International Journal of Hematology-Oncology and Stem Cell Research, 2018
Background: Hodgkin's lymphoma (HL) is a unique cancer of lymphocytes that has unknown reason. As lymphocytes are found throughout the lymphatic system, HL can start almost anywhere in the body.
Fatemeh Javanmardi, Amal Saki-Malehi, Ahmad Ahmadzadeh, Fakher Rahim   +3 more
doaj  

Abstract Introduction of a Novel Pathogenic Variant (c.1684G>A) in The SOX5 Gene Associated With Lamb–Shaffer Syndrome in a Family From North of Iran

Case Reports in Clinical Practice
So far, different types of SOX5 variants have been reported in patients with LAMSHF syndrome, which are mainly clustered in the HMG domain. The LAMSHF syndrome has a broad variety of clinical manifestations such as developmental delay, speech delay ...
Akbar Amirfiroozy, Hossein Jalali, Atefeh Khoshaeen, Mohammad Reza Mahdavi, Mahan Mahdavi   +4 more
doaj   +1 more source

Clinical and Haematologic Correlates of Soluble VCAM‐1 in Adults With Steady‐State Sickle Cell Disease

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Background Endothelial activation contributes to the vasculopathy of sickle cell disease (SCD). We evaluated serum soluble vascular cell adhesion molecule‐1 (sVCAM‐1), a surrogate marker of endothelial activation, and examined its clinical and haematologic correlates in adults with steady‐state SCD.
William Kwesi Ghunney, Eugenia Vicky Asare, John Benaiah Ayete‐Nyampong, Wonder Doku‐Agama, Eric Kyei‐Baafour, Michael Fokou Ofori, George Obeng Adjei, Edeghonghon Olayemi   +7 more
wiley   +1 more source

Prevalence of hemoglobinopathy, ABO and rhesus blood groups in rural areas of West Bengal, India

Journal of Research in Medical Sciences, 2012
Background: Hemoglobinopathies are a group of inherited disorders of hemoglobin synthesis. It could be formed a fatal scenario in concern of lacking of actual information.
Bikash Mondal, Soumyajit Maiti, Biplab Kumar Biswas, Debidas Ghosh, Shyamapada Paul   +4 more
doaj  

Maternal and Fetal Outcomes of Pregnant Women With Sickle Cell Disease: A Single‐Center Canadian Study

eJHaem, Volume 7, Issue 5, October 2026.
ABSTRACT Background Sickle cell disease (SCD) increases the risk of complications during pregnancy. This study describes antenatal care patterns and maternal and fetal outcomes in pregnant women with SCD in a Canadian setting. Methods Women with SCD receiving antenatal/perinatal care through the Southern Alberta Rare Blood and Bleeding Disorders ...
Wing Man (Joanne) Lam, Natalia Rydz, Nancy Soliman, Dawn Goodyear, Kelsey Uminski   +4 more
wiley   +1 more source

Integrating Gaucher disease (GD) into mainstream hematological curriculum training

HemaSphere, Volume 10, Issue 10, October 2026.
Colm Bradley, Argiris Symeonidis, Sam Salek, Nkemdirim Jacob   +3 more
wiley   +1 more source