Results 41 to 50 of about 87,648 (351)

Neocytolysis: How to Get Rid of the Extra Erythrocytes Formed by Stress Erythropoiesis Upon Descent From High Altitude

open access: yesFrontiers in Physiology, 2018
Neocytolysis is the selective destruction of those erythrocytes that had been formed during stress-erythropoiesis in hypoxia in order to increase the oxygen transport capacity of blood.
Heimo Mairbäurl
doaj   +1 more source

Xenotransplantation: Perspectives and limits [PDF]

open access: yes, 2001
Xenotransplantation faces the dilemma of an unlimited supply of cells, tissues and organs on the one hand and severe obstacles and limits on the other. One reason for the limitations is that the source animal of choice, the pig, and the human recipient ...
Hammer, Claus
core   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Effects of ultra-purified polymerized bovine hemoglobin on local tissue oxygen tension in striated skin muscle - An efficacy study in the hamster [PDF]

open access: yes, 2002
The development of hemoglobin-based oxygen carriers has been propagated for replacement of the oxygen carrying properties of red blood cells for almost one century.
Botzlar, Andreas   +2 more
core   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

open access: yesMolecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim   +8 more
wiley   +1 more source

Evidence for multiple structural genes for the γ chain of human fetal hemoglobin [PDF]

open access: yes, 1968
A sequence with a specific residue at each position was proposed for the γ chain of human fetal hemoglobin by Schroeder et al. (1) after a study in which hemoglobin from a number of individual infants was used.
Dozy, Andrée M.   +6 more
core  

Nitrosative stress defences of the enterohepatic pathogenic bacterium Helicobacter pullorum [PDF]

open access: yes, 2017
Helicobacter pullorum is an avian bacterium that causes gastroenteritis, intestinal bowel and hepatobiliary diseases in humans. Although H. pullorum has been shown to activate the mammalian innate immunity with release of nitric oxide (NO), the proteins ...
Boneca, Ivo G.   +6 more
core   +3 more sources

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Determination of Beta Thalassemia trait and abnormal Hemoglobin variant frequency

open access: yesIberoamerican Journal of Medicine
Introduction: Hemoglobinopathies are among the most common hereditary disorders globally, classified into thalassemias and abnormal hemoglobins. Abnormal hemoglobins arise from genetic alterations like point mutations, insertions, or deletions, with Hb S,
Miraç Seher Helvacı   +7 more
doaj   +1 more source

A 1H NMR comparative study of human adult and fetal hemoglobins [PDF]

open access: yes, 1998
The affinities of the individual subunits in human adult and fetal hemoglobins to azide ion have been determined from the combined analysis of NMR and optical titration data. Structural and functional non-equivalence of the constituent subunits, i.e.
Arts, Eus G. J. M.   +5 more
core   +3 more sources

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