Results 161 to 170 of about 8,824 (214)

Long-term effectiveness and safety of ravulizumab in paroxysmal nocturnal hemoglobinuria: a plain language summary. [PDF]

J Comp Eff Res
Arrais C, Carnelutto N, Reyes J.
europepmc   +1 more source

Paroxysmal Nocturnal Hemoglobinuria in Children

Pediatric Drugs, 2007
Paroxysmal nocturnal hemoglobinuria (PNH), an acquired hematologic disorder characterized by intravascular hemolysis, nocturnal hemoglobinuria, thrombotic events, serious infections, and bone marrow failure, is very rare in children. PNH is caused by a somatic mutation of the phosphatidylinositol glycan (GPI) complementation class A (PIGA) gene ...
Heuvel-Eibrink, M.M. (Marry) van den, Van den Heuvel - Eibrink, Marry   +1 more
openaire   +4 more sources

Pregnancy and paroxysmal nocturnal hemoglobinuria

European Journal of Obstetrics & Gynecology and Reproductive Biology, 1994
A patient is described who developed symptoms of paroxysmal nocturnal hemoglobinuria (PNH) in her first pregnancy. This was uneventful except for a spontaneous preterm delivery. The second pregnancy was complicated by severe anemia and a hemolytic crisis with Budd-Chiari syndrome at 31 weeks' amenorrhoea.
Bais, J., Pel, M., von dem Borne, A., van der Lelie, H.   +3 more
openaire   +4 more sources

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Paroxysmal Cold Hemoglobinuria

Hematology/Oncology Clinics of North America, 2015
Paroxysmal cold hemoglobinuria is a rare cause of autoimmune hemolytic anemia predominantly seen as an acute form in young children after viral illnesses and in a chronic form in some hematological malignancies and tertiary syphilis. It is a complement mediated intravascular hemolytic anemia associated with a biphasic antibody against the P antigen on ...
Satish, Shanbhag, Jerry, Spivak
openaire   +2 more sources

Pegcetacoplan for paroxysmal nocturnal hemoglobinuria

Blood, 2022
AbstractApproximately a third of patients with paroxysmal nocturnal hemoglobinuria (PNH) remain transfusion dependent or have symptomatic anemia despite treatment with a C5 inhibitor. Pegcetacoplan inhibits complement proximally at the level of C3 and is highly effective in treating persistent anemia resulting from C3-mediated extravascular hemolysis ...
Gloria F. Gerber, Robert A. Brodsky
openaire   +2 more sources

Paroxysmal nocturnal hemoglobinuria

Hématologie, 2013
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disorder of hematopoietic stem cells. PNH is related to a somatic mutation in the phosphatidylinositol glycan class A (PIG-A), X-linked gene, responsible for a deficiency in glycosylphosphatidylinositol-anchored proteins (GPI-AP).
R, Peffault de Latour, Z, Amoura, G, Socié   +2 more
openaire   +2 more sources