Results 181 to 190 of about 8,824 (214)

Paroxysmal Nocturnal Hemoglobinuria

New England Journal of Medicine, 1961
PAROXYSMAL nocturnal hemoglobinuria is a disease with a fascinating diversity of challenges and implications. These have prompted numerous clinical and basic investigations. The clinical features are often bizarre and may be misleading, even with the most typical presentation of abdominal pain, fatigue, weakness, anemia and dark urine and with venous ...
openaire   +2 more sources

Paroxysmal Nocturnal Hemoglobinuria Revisited

New England Journal of Medicine, 1983
Immunologic systems are now known to have a major role in the pathophysiology of many human disease processes. One such system is serum complement.
openaire   +2 more sources

Acute Paroxysmal Cold Hemoglobinuria

Transfusion Medicine Reviews, 1989
Over eighty years have passed since Donath and Landsteiner identified the syndrome of PCH and reported an in vitro test for its diagnosis. The accuracy of their observations, and the usefulness of the DL procedure has persisted. PCH has been investigated over the years providing further information regarding antibody specificity and serological ...
openaire   +2 more sources

The pathophysiology of paroxysmal nocturnal hemoglobinuria

Experimental Hematology, 2007
The molecular basis of PNH is known. Somatic mutation of the X-chromosome gene PIGA accounts for deficiency of glycosyl phosphatidylinositol-anchored proteins (GPI-AP) on affected hematopoietic stem cells and their progeny. However, neither mutant PIGA nor the consequent deficiency of GPI-AP provides a direct explanation for the clonal outgrowth of the
openaire   +2 more sources

Paroxysmal Nocturnal Hemoglobinuria

New England Journal of Medicine, 1952
THE most accurate method of study of any disease is enlightened statistical analysis of a large number of cases. However, paroxysmal nocturnal hemoglobinuria is a rare blood dyscrasia; approximately 45 cases, not all of convincing authenticity, have appeared in the literature to this time.9 Consequently, no physician or group of physicians is likely to
openaire   +2 more sources

SYPHILITIC PAROXYSMAL COLD HEMOGLOBINURIA

Annals of Internal Medicine, 1957
Excerpt Paroxysmal cold hemoglobinuria is a rare hemolytic disorder of which there are two distinct varieties.
openaire   +2 more sources

Eculizumab in Paroxysmal Nocturnal Hemoglobinuria

New England Journal of Medicine, 2006
To the Editor: The study of eculizumab by Hillmen et al. (Sept. 21 issue)1 showed stabilization of hemoglobin levels and a reduction in transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria (PNH). However, there were more patients with a history of aplastic anemia in the placebo group than in the eculizumab group (27% vs.
openaire   +2 more sources

Paroxysmal and Non-Paroxysmal Atrial Fibrillation in Middle Eastern Patients: Clinical Features and the Use of Medications. Analysis of the Jordan Atrial Fibrillation (JoFib) Study

International Journal of Environmental Research and Public Health, 2022
Hanna Al-Makhamreh, Nasr Alrabadi, Mohammad Krishan   +2 more
exaly  

Paroxysmal Hemoglobinuria

New England Journal of Medicine, 1932
FRANCIS P. MC CARTHY, ROBERT WILSON
openaire   +1 more source

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

Journal of the American Medical Association, 1960
openaire   +2 more sources