Results 71 to 80 of about 7,137 (182)

Outcomes of dengue infection in adults with underlying haematological diseases in Brazil during 2024 and 2025

British Journal of Haematology, Volume 209, Issue 1, Page 324-328, July 2026.
K. Tozatto‐Maio, V. Weihermann, C. W. Erthal, M. W. Araújo, C. R. Gomes, K. Caciola, L. Otuyama, J. Gasparini, H. R. Higashino, S. F. Costa, A. N. Duarte‐Neto, F. S. Seguro, P. R. Villaça, E. D. R. P. Velloso, S. F. M. Gualandro, Y. Nukui, V. Rocha   +16 more
wiley   +1 more source

Expert Consensus of Multidisciplinary Diagnosis and Treatment for Paroxysmal Nocturnal Hemoglobinuria(2024)

Xiehe Yixue Zazhi
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disease caused by abnormal expression of glycosylphosphatidylinositol (GPI) on the cell membrane due to mutations in the phosphatidylinositol glycan class A(PIGA ...
CHEN Miao, YANG Chen, LIU Ziwei, CAO Wei, ZHANG Bo, LIU Xin, LI Jingnan, LIU Wei, PAN Jie, WANG Jian, ZHENG Yuehong, CHEN Yuexin, LI Fangda, DU Shunda, NING Cong, CHEN Limeng, YUE Cai, NI Jun, PENG Min, GUO Xiaoxiao, WANG Tao, LI Hongjun, LI Rongrong, WU Tong, HAN Bing, ZHANG Shuyang, Multidiscipline Collaboration Group on Rare Disease at Peking Union Medical College Hospital   +26 more
doaj   +1 more source

Pathogenesis of paroxysmal nocturnal hemoglobinuria

Blood
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal hematopoietic disorder. There are 2 components to the pathogenesis of PNH: (1) a mutant stem cell and (2) expansion of the mutant clone. Component 1 is straightforward: there is almost always an inactivating somatic mutation of the X-linked ...
Lucio Luzzatto, Shinji Nakao
openaire   +2 more sources

Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria

PLOS Computational Biology, 2018
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemolysis and a high risk of thrombosis, that is due to a deficiency in several cell surface proteins that prevent complement activation. Its origin has been traced to a somatic mutation in the PIG-A gene within hematopoietic stem cells (HSC).
Nathaniel Mon Père, Tom Lenaerts, Jorge M. Pacheco, David Dingli   +3 more
openaire   +6 more sources

Preoperative administration of eculizumab to prevent surgery‐triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria

Clinical Case Reports, 2018
Key Clinical message Eculizumab in pregnancy has been reported to be effective in improving outcomes in patients with paroxysmal nocturnal hemoglobinuria. However, a cesarean section may result in surgery‐triggered hemolysis.
Dongping Li, Liangcheng Wang, Isao Horiuchi, Shun‐ichi Kimura, Kenro Chikazawa, Azusa Kimura, Shigetane Sasaki, Tomoyuki Kuwata, Kenjiro Takagi   +8 more
doaj   +1 more source

Successful haploidentical hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria with severe pancytopenia developed after long‐term aplastic anemia treatment

Clinical Case Reports
Key Clinical Message Haploidentical hematopoietic stem cell transplantation (HSCT) with posttransplant cyclophosphamide is an alternative treatment for aplastic anemia–paroxysmal nocturnal hemoglobinuria (PNH) syndrome with poor prognostic factors ...
Kazuki Sakurai, Kei Saito, Shunsuke Hatta, Yuna Katsuoka, Kuniaki Meguro, Hisayuki Yokoyama, Toru Izumi   +6 more
doaj   +1 more source

Necrotizing Fasciitis in Paroxysmal Nocturnal Hemoglobinuria

Case Reports in Hematology, 2015
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, progressive, and life-threatening hematopoietic stem cell disorder characterized by complement-mediated intravascular hemolysis and a prothrombotic state.
Pusem Patir, Yakup Isik, Yigit Turk, Mehmet Can Ugur, Cengiz Ceylan, Gulnur Gorgun, Nihal Mete Gokmen, Guray Saydam, Fahri Sahin   +8 more
doaj   +1 more source

Paroxysmal nocturnal hemoglobinuria and thrombosis

Акушерство, гинекология и репродукция
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal hematopoiesis disorder caused by a somatic mutation in the PIGA (phosphatidylinositol glycan, class A) gene, resulting in deficiency of glycosylphosphatidylinositol (GPI)anchored ...
A. R. Khisamieva, A. R. Oskolkova, V. O. Bitsadze, J. Kh. Khizroeva, N. A. Makatsariya, M. V. Tretyakova, N. R. Gashimova, K. N. Grigoreva, D. V. Blinov, J.-Ch. Gris, I. Elalamy, G. Gerotziafas, A. D. Makatsariya   +12 more
doaj   +1 more source

A Case Presenting with Acute Kidney Injury and Paroxysmal Nocturnal Hemoglobinuria

Turkish Journal of Nephrology, 2019
There may be different clinical presentations of kidney involvement in the course of paroxysmal nocturnal hemoglobinuria, within a spectrum of acute kidney injury, generally due to hemolysis, to chronic kidney disease.
Ezgi ÇOŞKUN YENİGÜN, Didem TURGUT, Simge BARDAK, Serhan PİŞKİNPAŞA, Nihal ÖZKAYAR, Eyüp KOÇ, Fatih DEDE   +6 more
doaj  

Anticomplement therapy

Biologics: Targets & Therapy, 2009
Prathit A Kulkarni1, Vahid Afshar-Kharghan21Baylor College of Medicine, Houston, Texas, USA; 2The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USAAbstract: The complement system is an important part of innate immunity; however, as ...
Prathit A Kulkarni, Vahid Afshar-Kharghan   +1 more
doaj