Results 81 to 90 of about 8,824 (214)

Herb-induced acute bone marrow intoxication and interstitial nephritis superimposing glomerular C1q deposition in a patient with paroxysmal nocturnal hemoglobinuria

Saudi Journal of Kidney Diseases and Transplantation, 2015
Paroxysmal nocturnal hemoglobinuria is a rare disease of the red blood cell membrane that renders it lyzable by the complement system, leading to chronic intravascular hemolysis. Renal hemosiderosis is a well-known complication of intravascular hemolytic
Deena T Boqari, Shatha Al Faraj, Maria Arafah, Nourah Aloudah, Khalid S Alkhairy, Ahmed Alsuhaibani, Khaled O Alsaad   +6 more
doaj   +1 more source

Paroxysmal Nocturnal Hemoglobinuria and Acute Kidney Injury: A Case Report

, 2013
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare cause of hemolytic anemia. The major outlines of clinical presentation comprises findings of hemolysis, venous thrombosis and findings of bone marrow failure.
Rumeyza Kazancioglu, Ozturk, Savaş, Halil Donmez, KAZANCIOĞLU, Rümeyza, Gursu, Meltem, Kilicarslan, Isin, Isın Kilicarslan, Abdullah Sumnu, Meltem Gursu, Sumnu, Abdullah, Cebeci, Egemen, Savas Ozturk, Egemen Cebeci, Donmez, Halil   +13 more
core   +1 more source

Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia

, 2011
We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia.
Yazan Migdady, Adam J. Olszewski
core   +1 more source

Adult paroxysmal cold hemoglobinuria following mRNA COVID‐19 vaccination

, 2022
Paroxysmal cold hemoglobinuria (PCH) is an extremely rare subtype of autoimmune hemolytic anemia (AIHA) in adults. PCH is caused by the biphasic Donath–Landsteiner (DL) antibody which fixes complement to red blood cells at low temperatures and ...
Shirasu, Chinami, Hina Takano, Inano, Tadaaki, Miki Ando, Koyama, Daisuke, Takano, Hina, Michiaki Koike, Chinami Shirasu, Koike, Michiaki, Akemi Inoguchi, Ando, Miki, Tadaaki Inano, Iwao, Noriaki, Kyohei Misawa, Inoguchi, Akemi, Yasuda, Hajime, Daisuke Koyama, Noriaki Iwao, Misawa, Kyohei, Hajime Yasuda   +19 more
core   +1 more source

Treatment of paroxysmal nocturnal hemoglobinuria [PDF]

Blood, 1982
Patients with PNH may be treated with a number of known agents. As in all patients with a chronic disease, a regimen tolerable over a long period of time must be selected. Knowledge and anticipation of complications and their proper treatment are essential parts in the treatment.
openaire   +3 more sources

Severe cutaneous thrombosis with hemorrhagic necrosis in a patient with paroxysmal nocturnal hemoglobinuria: A case report and review of literature

Dermatologica Sinica, 2017
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic acquired clonal stem cell disorder, typically manifesting hemolysis, pancytopenia and thrombosis in various organs. PNH-associated cutaneous thrombosis is extremely rare.
Fu-Nien Hsieh, Tsai-Yun Chen, Julia Yu-Yun Lee   +2 more
doaj   +1 more source

Pathogenesis of paroxysmal nocturnal hemoglobinuria

Blood
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal hematopoietic disorder. There are 2 components to the pathogenesis of PNH: (1) a mutant stem cell and (2) expansion of the mutant clone. Component 1 is straightforward: there is almost always an inactivating somatic mutation of the X-linked ...
Lucio Luzzatto, Shinji Nakao
openaire   +2 more sources

Expert Consensus of Multidisciplinary Diagnosis and Treatment for Paroxysmal Nocturnal Hemoglobinuria(2024)

Xiehe Yixue Zazhi
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disease caused by abnormal expression of glycosylphosphatidylinositol (GPI) on the cell membrane due to mutations in the phosphatidylinositol glycan class A(PIGA ...
CHEN Miao, YANG Chen, LIU Ziwei, CAO Wei, ZHANG Bo, LIU Xin, LI Jingnan, LIU Wei, PAN Jie, WANG Jian, ZHENG Yuehong, CHEN Yuexin, LI Fangda, DU Shunda, NING Cong, CHEN Limeng, YUE Cai, NI Jun, PENG Min, GUO Xiaoxiao, WANG Tao, LI Hongjun, LI Rongrong, WU Tong, HAN Bing, ZHANG Shuyang, Multidiscipline Collaboration Group on Rare Disease at Peking Union Medical College Hospital   +26 more
doaj   +1 more source

A raman tweezer study with single red blood cells for the diagnosis of paroxysmal nocturnal hemoglobinuria

, 2022
© 2021 The Author (s).The surface structure of individual erythrocytes changes in the state of paroxysmal nocturnal hemoglobinuria.
Soysal, Kaan Batu, Yenerel, Mustafa, Başar, Günay, Ozbalak, Mustafa Murat, Unlu, Burcin, Mastanzade, Metban, Parlatan, Seyma, Parlatan, Ugur   +7 more
core  

Preoperative administration of eculizumab to prevent surgery‐triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria

Clinical Case Reports, 2018
Key Clinical message Eculizumab in pregnancy has been reported to be effective in improving outcomes in patients with paroxysmal nocturnal hemoglobinuria. However, a cesarean section may result in surgery‐triggered hemolysis.
Dongping Li, Liangcheng Wang, Isao Horiuchi, Shun‐ichi Kimura, Kenro Chikazawa, Azusa Kimura, Shigetane Sasaki, Tomoyuki Kuwata, Kenjiro Takagi   +8 more
doaj   +1 more source