Results 101 to 110 of about 32,733 (212)

Model-Informed Precision Dosing of Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria.

Contains fulltext : 322381.pdf (Publisher’s version ) (Open Access)BACKGROUND AND OBJECTIVE: Eculizumab is an expensive therapeutic monoclonal antibody inhibiting complement C5 and approved for various indications, including the rare ...
Heuvel, L.P.W.J. van den, Kar, N.C.A.J. van de, Heine, R. ter, Avest, M. ter, Langemeijer, S.M.C., Baas, L.M.   +5 more
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Successful haploidentical hematopoietic stem cell transplantation for paroxysmal nocturnal hemoglobinuria with severe pancytopenia developed after long‐term aplastic anemia treatment

Clinical Case Reports
Key Clinical Message Haploidentical hematopoietic stem cell transplantation (HSCT) with posttransplant cyclophosphamide is an alternative treatment for aplastic anemia–paroxysmal nocturnal hemoglobinuria (PNH) syndrome with poor prognostic factors ...
Kazuki Sakurai, Kei Saito, Shunsuke Hatta, Yuna Katsuoka, Kuniaki Meguro, Hisayuki Yokoyama, Toru Izumi   +6 more
doaj   +1 more source

Dual-Beam optical Manipulation of Red blood cells for the investigation of paroxysmal nocturnal hemoglobinuria

, 2022
© 2021 The Author(s).Paroxysmal nocturnal hemoglobinuria was studied using dual-beam optical tweezers. Force measurements show a moderate change between disease and healthy states.
Soysal, Kaan Batu, Yenerel, Mustafa, Ozbalak, Mustafa Murat, Unlu, Burcin, Mastanzade, Metban, Parlatan, Seyma, Parlatan, Ugur   +6 more
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De novo smoldering paroxysmal nocturnal hemoglobinuria: a flow cytometric diagnosis

Haematologica, 1997
An asymptomatic 26-year-old woman with mild macrocytic anemia (11.6 g Hb/dl) was studied. All biochemical parameters, bone marrow histology and cytogenetics were normal. The Ham's and sucrose tests were negative.
R Fores, G Bautista, JL Steegmann, F Javier Penalver, R Cabrera, MN Fernandez   +5 more
doaj  

The frequency of HLA class I alleles in Japanese patients with bone marrow failure

Haematologica, 2006
The frequencies of the HLA-B*4002 and HLA-A*0206 alleles in patients with aplastic anemia (AA) (n=32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH) (n=24; 22.9%), respectively, were significantly different from those in controls (n=371; 8.6 ...
T Shichishima, H Noji, K Ikeda, K Akutsu, Y Maruyama   +4 more
doaj  

Paroxysmal nocturnal hemoglobinuria and thrombosis

Акушерство, гинекология и репродукция
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal hematopoiesis disorder caused by a somatic mutation in the PIGA (phosphatidylinositol glycan, class A) gene, resulting in deficiency of glycosylphosphatidylinositol (GPI)anchored ...
A. R. Khisamieva, A. R. Oskolkova, V. O. Bitsadze, J. Kh. Khizroeva, N. A. Makatsariya, M. V. Tretyakova, N. R. Gashimova, K. N. Grigoreva, D. V. Blinov, J.-Ch. Gris, I. Elalamy, G. Gerotziafas, A. D. Makatsariya   +12 more
doaj   +1 more source

Paroxysmal Nocturnal Hemoglobinuria: Diagnostic Challenges in Pediatric Patient

, 2019
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening hematologic stem cell disorder characterized by hemoglobinuria, thrombosis, and tendency for bone marrow failure.
Anna Sechser Perl, Inna Kaminecki, Dharshana Krishnaprasadh, Jonathan Teitelbaum   +3 more
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Baseline characteristics and disease burden in patients in the International Paroxysmal Nocturnal Hemoglobinuria Registry

Paroxysmal nocturnal hemoglobinuria is a rare, acquired disease associated with hemolytic anemia, bone marrow failure, thrombosis, and, frequently, poor quality of life.
Khursigara, Gus, Szer, Jeffrey, Brodsky, Robert A., Kanakura, Yuzuru, Urbano Ispizua, Álvaro, Schrezenmeier, Hubert, Hillmen, Peter, Muus, Petra, Maciejewski, Jaroslaw P., Socié, Gérard, Bessler, Monica, Bedrosian, Camille L., Rosse, Wendell   +12 more
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Acute tubular necrosis in a patient with paroxysmal nocturnal hemoglobinuria

, 2013
Acute renal failure (ARF) is a well-recognized complication of paroxysmal nocturnal hemoglobinuria (PNH). The predominant mechanism is intravascular hemolysis resulting in massive hemoglobinuria ARF.
Rushika L Lanarolle, Eranga S Wijewickrama, Chandu De Silva, Lalindra Gooneratne   +3 more
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The immune response dis-regulation and the pathogenesis of hematopoietic disorders [PDF]

, 2008
Sica, Michela
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