Results 91 to 100 of about 32,733 (212)

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) DENGAN HYPERCOAGULABLE STATE [PDF]

, 2018
Paroxysmal nocturnal hemoglobinuria (PNH) adalah kelainan kronis didapat (acquired) yang ditandai terjadinya hemolisis intravaskuler dan hemoglobinuria yang pada umumnya terjadi pada saat pasien tidur di malam hari.
Irza Wahid, Wahid, Irza, Fitrach Desfiyanda, Desfiyanda, Fitrach   +3 more
core   +1 more source

The Prevalence of Paroxysmal Nocturnal Hemoglobinuria Clone in Adult Patients with Idiopathic Pulmonary Hypertension [PDF]

, 2018
Aim: Paroxysmal nocturnal hemoglobinuria (PNH) a is a clonal disorder that may lead to several conditions such as thromboses, Budd-Chiari syndrome, renal failure, impotence, and pulmonary hypertension (pHT).
Mesut Ayer, Tayfun Elibol, Cengiz Bal, Ayer, Mesut, Mehmet Serdar Küçükoğlu, Kucukoglu, Mehmet Serdar, Ümit Yaşar Sinan, BAL, CENGİZ, Sinan, Umit Yasar, ELİBOL, TAYFUN   +9 more
core   +1 more source

Renal manifestations in paroxysmal nocturnal hemoglobinuria

Indian Journal of Nephrology, 2017
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired chronic disorder characterized by a triad of clinical features - hemolytic anemia, pancytopenia, and thrombosis. Not many reports of renal involvement in PNH are available in literature. We present a case series of PNH with renal involvement.
Ram, R., Adiraju, K. P., Gudithi, S., Dakshinamurty, K. V.   +3 more
openaire   +2 more sources

Evolutionary dynamics of paroxysmal nocturnal hemoglobinuria

PLOS Computational Biology, 2018
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal blood disorder characterized by hemolysis and a high risk of thrombosis, that is due to a deficiency in several cell surface proteins that prevent complement activation. Its origin has been traced to a somatic mutation in the PIG-A gene within hematopoietic stem cells (HSC).
Nathaniel Mon Père, Tom Lenaerts, Jorge M. Pacheco, David Dingli   +3 more
openaire   +7 more sources

Expert Consensus of Multidisciplinary Diagnosis and Treatment for Paroxysmal Nocturnal Hemoglobinuria(2024)

Xiehe Yixue Zazhi
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disease caused by abnormal expression of glycosylphosphatidylinositol (GPI) on the cell membrane due to mutations in the phosphatidylinositol glycan class A(PIGA ...
CHEN Miao, YANG Chen, LIU Ziwei, CAO Wei, ZHANG Bo, LIU Xin, LI Jingnan, LIU Wei, PAN Jie, WANG Jian, ZHENG Yuehong, CHEN Yuexin, LI Fangda, DU Shunda, NING Cong, CHEN Limeng, YUE Cai, NI Jun, PENG Min, GUO Xiaoxiao, WANG Tao, LI Hongjun, LI Rongrong, WU Tong, HAN Bing, ZHANG Shuyang, Multidiscipline Collaboration Group on Rare Disease at Peking Union Medical College Hospital   +26 more
doaj   +1 more source

Paroxysmal Nocturnal Hemoglobinuria Presenting with a Left Intraventricular Thrombus in a Patient with Prior Thymoma and Aplastic Anemia

, 2011
We report the case of a 37-year old man presenting with a left ventricular cardiac thrombus in the setting of subclinical paroxysmal nocturnal hemoglobinura (PNH) developing two years after immunosuppressive therapy for thymoma-associated aplastic anemia.
Yazan Migdady, Adam J. Olszewski
core   +1 more source

Pathogenesis of paroxysmal nocturnal hemoglobinuria

Blood
Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a nonmalignant clonal hematopoietic disorder. There are 2 components to the pathogenesis of PNH: (1) a mutant stem cell and (2) expansion of the mutant clone. Component 1 is straightforward: there is almost always an inactivating somatic mutation of the X-linked ...
Lucio Luzzatto, Shinji Nakao
openaire   +2 more sources

Preoperative administration of eculizumab to prevent surgery‐triggered hemolysis during cesarean section with paroxysmal nocturnal hemoglobinuria

Clinical Case Reports, 2018
Key Clinical message Eculizumab in pregnancy has been reported to be effective in improving outcomes in patients with paroxysmal nocturnal hemoglobinuria. However, a cesarean section may result in surgery‐triggered hemolysis.
Dongping Li, Liangcheng Wang, Isao Horiuchi, Shun‐ichi Kimura, Kenro Chikazawa, Azusa Kimura, Shigetane Sasaki, Tomoyuki Kuwata, Kenjiro Takagi   +8 more
doaj   +1 more source

A raman tweezer study with single red blood cells for the diagnosis of paroxysmal nocturnal hemoglobinuria

, 2022
© 2021 The Author (s).The surface structure of individual erythrocytes changes in the state of paroxysmal nocturnal hemoglobinuria.
Soysal, Kaan Batu, Yenerel, Mustafa, Başar, Günay, Ozbalak, Mustafa Murat, Unlu, Burcin, Mastanzade, Metban, Parlatan, Seyma, Parlatan, Ugur   +7 more
core  

Off-Pump Coronary Revascularization Using Bilateral Internal Thoracic Arteries in A Patient with Paroxysmal Nocturnal Hemoglobinuria: A Case Report

, 2019
Paroxysmal nocturnal hemoglobinuria (PNH) is an ultra-orphan disease. We report the first case in the literature of Off-Pump Coronary Revascularization Using Bilateral Internal Thoracic Arteries in a patient with paroxysmal nocturnal hemoglobinuria. A 36-
Juan Mariano Vrancic (5628258), Daniel Navia (4732464), Manuel Roque Cervetti (5628244), Julián Benavides (7316717)   +3 more
core   +1 more source