Results 31 to 40 of about 22,483 (254)

Drowning Hemoglobinuria

The Tohoku Journal of Experimental Medicine, 1922
KUMAO YAMAKAMI
openaire   +3 more sources

Safety and efficacy of pegcetacoplan in paroxysmal nocturnal hemoglobinuria

Therapeutic Advances in Hematology, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, hematologic disease characterized by complement-mediated hemolysis, thrombosis, and various degrees of bone marrow dysfunction.
R. Wong
semanticscholar   +1 more source

Paroxysmal nocturnal hemoglobinuria: advances in the understanding of pathophysiology, diagnosis, and treatment.

Polish Archives of Internal Medicine, 2022
In recent years, "old" paroxysmal nocturnal hemoglobinuria (PNH) has achieved new advances in terms of the understanding of its pathophysiology, modern approach to diagnostics, optimization of therapy, and dynamic development of new therapeutic agents ...
U. Szlendak, B. Budziszewska, Justyna Spychalska, Joanna Drozd-Sokołowska, E. Patkowska, J. Nowak   +5 more
semanticscholar   +1 more source

Symptom patterns in adult patients stung by scorpions with emphasis on coagulopathy and hemoglubinuria

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
The aim of this retrospective descriptive study was to highlight clinical manifestations 24-48 hours following referral of adult patients stung by scorpions.
AH Rahmani, A Jalali
doaj   +1 more source

Baseline clinical characteristics and disease burden in patients with paroxysmal nocturnal hemoglobinuria (PNH): updated analysis from the International PNH Registry

Annals of Hematology, 2020
The International Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry (NCT01374360) was initiated to optimize patient management by collecting data regarding disease burden, progression, and clinical outcomes.
H. Schrezenmeier, A. Röth, David J Araten, Y. Kanakura, L. Larratt, J. Shammo, A. Wilson, Gilda Shayan, J. Maciejewski   +8 more
semanticscholar   +1 more source

Pegcetacoplan for Paroxysmal Nocturnal Hemoglobinuria.

Blood, 2022
Approximately a third of patients with paroxysmal nocturnal hemoglobinuria (PNH) remain transfusion dependent or have symptomatic anemia despite treatment with a C5 inhibitor.
G. Gerber, R. Brodsky
semanticscholar   +1 more source

The complement C5 inhibitor crovalimab in paroxysmal nocturnal hemoglobinuria.

Blood, 2020
Complement C5 inhibition is the standard of care (SoC) for patients with paroxysmal nocturnal hemoglobinuria (PNH) with significant clinical symptoms. Constant and complete suppression of the terminal complement pathway and the high serum concentration ...
A. Röth, J. Nishimura, Z. Nagy, Júlia Gaál-Weisinger, J. Panse, S. Yoon, M. Egyed, S. Ichikawa, Yoshikazu Ito, Jin Seok Kim, H. Ninomiya, H. Schrezenmeier, S. Sica, K. Usuki, F. Sicre de Fontbrune, J. Soret, A. Sostelly, J. Higginson, A. Dieckmann, B. Gentile, J. Anzures‐Cabrera, K. Shinomiya, Gregor Jordan, Marta Biedzka-Sarek, B. Klughammer, A. Jahreis, C. Bucher, R. Peffault de Latour   +27 more
semanticscholar   +1 more source

The importance of terminal complement inhibition in paroxysmal nocturnal hemoglobinuria

Therapeutic Advances in Hematology, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, chronic hematologic disorder associated with inappropriate terminal complement activity on blood cells that can result in intravascular hemolysis (IVH), thromboembolic events (TEs), and organ damage ...
A. Kulasekararaj, R. Brodsky, J. Nishimura, Christopher J. Patriquin, H. Schrezenmeier   +4 more
semanticscholar   +1 more source

Danicopan: an oral complement factor D inhibitor for paroxysmal nocturnal hemoglobinuria

Haematologica, 2020
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by complement-mediated intravascular hemolysis due to the absence of complement regulators CD55 and CD59 on affected erythrocytes.
A. Risitano, A. Kulasekararaj, J. W. Lee, J. Maciejewski, R. Notaro, R. Brodsky, Mingjun Huang, M. Geffner, P. Browett   +8 more
semanticscholar   +1 more source

Insights Into the Emergence of Paroxysmal Nocturnal Hemoglobinuria

Frontiers in Immunology, 2022
Paroxysmal Nocturnal Hemoglobinuria (PNH) is a disease as simple as it is complex. PNH patients develop somatic loss-of-function mutations in phosphatidylinositol N-acetylglucosaminyltransferase subunit A gene (PIGA), required for the biosynthesis of ...
Melissa A. Colden, Sushant Kumar, Bolormaa Munkhbileg, D. Babushok   +3 more
semanticscholar   +1 more source