Results 21 to 30 of about 13,040 (222)

Frequency of paroxysmal nocturnal hemoglobinuria in patients attended in Belém, Pará, Brazil [PDF]

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: Paroxysmal nocturnal hemoglobinuria is a hematological disease with complex physiopathology. It is genetically characterized by a somatic mutation in the PIG-A gene (phosphatidylinositol glycan anchor biosynthesis, class A), in which the best
Lacy Cardoso de Brito Junior, Maria do Socorro de Oliveira Cardoso, Euzamar Gaby Rocha, Herika Anijar, Mariana Cunha, João Carlos Pina Saraiva   +5 more
doaj   +2 more sources

Paroxysmal nocturnal hemoglobinuria revealed by atypical thromboses: A case of cerebral, hepatic, and portal vein involvement leading to cirrhosis [PDF]

Radiology Case Reports
Paroxysmal nocturnal hemoglobinuria is a rare clonal stem cell disorder characterized by ongoing intravascular hemolysis, frequent bone marrow dysfunction, and a markedly elevated risk of thrombosis.
Majda Malghi, MD, Mehdi Zouaoui, MD, Ibtissam Bamaarouf, MD, Sara Messaoudi, MD, Youssef Hnach, MD, Mbarek Azouaoui, MD, Nourdin Aqodad, MD   +6 more
doaj   +2 more sources

Paroxysmal Nocturnal Hemoglobinuria: Diagnostic Challenges in Pediatric Patient

Case Reports in Pediatrics, 2019
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, life-threatening hematologic stem cell disorder characterized by hemoglobinuria, thrombosis, and tendency for bone marrow failure.
Dharshana Krishnaprasadh, Inna Kaminecki, Anna Sechser Perl, Jonathan Teitelbaum   +3 more
doaj   +2 more sources

Meningococcal Sepsis in Patient with Paroxysmal Nocturnal Hemoglobinuria during Pegcetacoplan Therapy

Emerging Infectious Diseases
Complement C5 inhibitors bring an increased risk for Neisseria infections. A novel complement C3 inhibitor, pegcetacoplan, was recently approved to treat paroxysmal nocturnal hemoglobinuria, a condition commonly treated with complement C5 inhibitors. We
Leo Starck, Vuokko Nummi, Eira Poikonen, Anna-Elina Lehtinen, Pia Kivelä, Nathalie Friberg, Jukka Torvikoski, Maija Toropainen, Seppo Meri   +8 more
doaj   +2 more sources

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria [PDF]

, 2004
Background<br/><br/> Mutations in the gene coding for the RNA component of telomerase, hTERC, have been found in autosomal dominant dyskeratosis congenita (DC) and aplastic anemia.
Ulku, B., Bessler, M., Bilsland, A., Mason, Philip J, Vulliamy, T., Serakinci, Nedime, Dokal, I., Ar, C., Ar, C, Marrone, Anna, Dokal, Inderjeet, Ulku, B, Bessler, Monica, Erzik, C, Serakinci, N, Serakinci, N., Marrone, A, Zhao, Jiangqin, Zhao, J, Dokal, I, Bilsland, A, Mason, PJ, Bilsland, Alan, Ulku, Birsen, Keith, W.N., Bessler, M, Vulliamy, T, Vulliamy, Tom, Keith, W Nicol, Erzik, Can, Marrone, A., Erzik, C., Zhao, J., Mason, P.J., Ar, Cem, Keith, WN   +35 more
core   +1 more source

Symptom patterns in adult patients stung by scorpions with emphasis on coagulopathy and hemoglubinuria

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
The aim of this retrospective descriptive study was to highlight clinical manifestations 24-48 hours following referral of adult patients stung by scorpions.
AH Rahmani, A Jalali
doaj   +1 more source

Hemoglobinemia and Hemoglobinuria [PDF]

The American Journal of the Medical Sciences, 1912
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openaire   +2 more sources

Paroxysmal Nocturnal Hemoglobinuria [PDF]

Blood, 2014
AbstractParoxysmal nocturnal hemoglobinuria (PNH) is a rare bone marrow failure disorder that manifests with hemolytic anemia, thrombosis, and peripheral blood cytopenias. The absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontrolled complement activation that accounts for hemolysis and other PNH ...
openaire   +2 more sources

Hemoglobinuria producida por una fístula en la sutura perivalvular post reemplazo con prótesis valvular mitral

Acta Médica Peruana, 2001
Se presenta el caso de un paciente de sexo masculino, de 65 años de edad, portador de una cardiopatía isquémica y severo prolapso de la válvula mitral, que fue sometido a cirugía de revascularización con un puente aorto coronario utilizando la vena ...
Régulo Agusti, Alberto Yuen, José Parodi   +2 more
doaj   +1 more source

Spontaneous poisoning of cattle by onion (Allium cepa) in Brazil [PDF]

Pesquisa Veterinária Brasileira
: The state of Santa Catarina is the largest national producer of onions. The consumption of onion (Allium cepa) by domestic animals can cause hemolytic anemia and hyperhemoglobinemia of Heinz bodies in erythrocytes.
Gustavo Felipe G.P. Hugen, Daiane Ogliari, Nathalia S. Wicpolt, Elaine Melchioretto, Sandra D. Traverso, Claudia Wisser, Deise Hemckmeier, Aldo Gava   +7 more
doaj   +1 more source