Results 31 to 40 of about 22,402 (256)

Clinical and epidemiological features of paroxysmal cold hemoglobinuria: a systematic review

Blood Advances, 2023
Key Points • Among 230 reported cases, contemporary PCH has a median onset age of 5 years with no sex predilection.• PCH is associated with significant variability in DAT results, necessitating high clinical suspicion and DL testing.
J. Jacobs, Cristina A. Figueroa Villalba, Garrett S. Booth, Jennifer S. Woo, Laura D Stephens, Brian D. Adkins   +5 more
semanticscholar   +1 more source

A mutation in a functional Sp1 binding site of the telomerase RNA gene (hTERC) promoter in a patient with Paroxysmal Nocturnal Haemoglobinuria [PDF]

, 2004
Background<br/><br/> Mutations in the gene coding for the RNA component of telomerase, hTERC, have been found in autosomal dominant dyskeratosis congenita (DC) and aplastic anemia.
Ulku, B., Bessler, M., Bilsland, A., Mason, Philip J, Vulliamy, T., Serakinci, Nedime, Dokal, I., Ar, C., Ar, C, Marrone, Anna, Dokal, Inderjeet, Ulku, B, Bessler, Monica, Erzik, C, Serakinci, N, Serakinci, N., Marrone, A, Zhao, Jiangqin, Zhao, J, Dokal, I, Bilsland, A, Mason, PJ, Bilsland, Alan, Ulku, Birsen, Keith, W.N., Bessler, M, Vulliamy, T, Vulliamy, Tom, Keith, W Nicol, Erzik, Can, Marrone, A., Erzik, C., Zhao, J., Mason, P.J., Ar, Cem, Keith, WN, Tom Vulliamy, Alan Bilsland, W Nicol Keith, Jiangqin Zhao, Monica Bessler, Anna Marrone, Inderjeet Dokal, Nedime Serakinci, Philip J Mason, Cem Ar, Can Erzik, Birsen Ulku   +47 more
core   +2 more sources

Drowning Hemoglobinuria [PDF]

Blood, 1953
Abstract 1. A case of hemoglobinemia and hemoglobinuria with recovery following incomplete drowning is presented. 2. The pathogenesis of the intravascular hemolysis is discussed.
openaire   +2 more sources

Long‐term safety and efficacy of ravulizumab in patients with paroxysmal nocturnal hemoglobinuria: 2‐year results from two pivotal phase 3 studies

European Journal of Haematology, 2022
The complement component 5 (C5) inhibitor ravulizumab demonstrated non‐inferiority to eculizumab following 26 weeks of treatment in complement inhibitor‐naïve and complement inhibitor‐experienced patients with paroxysmal nocturnal hemoglobinuria (PNH ...
A. Kulasekararaj, M. Griffin, S. Langemeijer, K. Usuki, A. Kulagin, M. Ogawa, Ji Yu, A. Mujeebuddin, J. Nishimura, J. W. Lee, Régis Peffault de Latour   +10 more
semanticscholar   +1 more source

Consensus statement for diagnosis and treatment of paroxysmal nocturnal haemoglobinuria

Hematology, Transfusion and Cell Therapy, 2021
Paroxysmal nocturnal hemoglobinuria is a chronic, multi-systemic, progressive and life-threatening disease characterized by intravascular hemolysis, thrombotic events, serious infections and bone marrow failure.
Rodolfo D. Cançado, Aderson da Silva Araújo, Alex Freire Sandes, Celso Arrais, Clarisse Lopes de Castro Lobo, Maria Stella Figueiredo, Sandra Fátima Menosi Gualandro, Sara Teresinha Olalla Saad, Fernando Ferreira Costa   +8 more
doaj   +1 more source

The complement alternative pathway in paroxysmal nocturnal hemoglobinuria: From a pathogenic mechanism to a therapeutic target

Immunological Reviews, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal, not malignant, hematological disease characterized by intravascular hemolysis, thrombophilia and bone marrow failure.
A. Risitano, C. Frieri, E. Urciuoli, L. Marano   +3 more
semanticscholar   +1 more source

Spontaneous poisoning of cattle by onion (Allium cepa) in Brazil [PDF]

Pesquisa Veterinária Brasileira
: The state of Santa Catarina is the largest national producer of onions. The consumption of onion (Allium cepa) by domestic animals can cause hemolytic anemia and hyperhemoglobinemia of Heinz bodies in erythrocytes.
Gustavo Felipe G.P. Hugen, Daiane Ogliari, Nathalia S. Wicpolt, Elaine Melchioretto, Sandra D. Traverso, Claudia Wisser, Deise Hemckmeier, Aldo Gava   +7 more
doaj   +1 more source

Hemoglobinemia and Hemoglobinuria [PDF]

The American Journal of the Medical Sciences, 1912
n ...
openaire   +2 more sources

Inhibition of C3 with pegcetacoplan results in normalization of hemolysis markers in paroxysmal nocturnal hemoglobinuria

Annals of Hematology, 2022
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired hematologic disorder characterized by complement-mediated hemolysis. C5 inhibitors (eculizumab/ravulizumab) control intravascular hemolysis but do not prevent residual extravascular hemolysis.
R. Wong, H. Pullon, Ismail Amine, A. Bogdanović, Pascal Deschatelets, C. Francois, K. Ignatova, S. Issaragrisil, P. Niparuck, T. Numbenjapon, E. Roman, J. Sathar, Raymond Xu, M. Al-Adhami, L. Tan, E. Tse, F. Grossi   +16 more
semanticscholar   +1 more source

Exertional Hemoglobinuria

The Tohoku Journal of Experimental Medicine, 1975
A 16 years old boy had a typical exertional hemoglobinuria after walking with his new leather shoes on. The attacks of hemoglobinuria were associated with the appearance of an unstable hemoglobin in red cells. A slightly decreased fragility curve by 24 hr incubated red cells, the increase of autohemolysis and the appearance of heat labile hemoglobin ...
OHNO, YASUHICO, SATO, MASATSUGU, KUROKAWA, IZUMI, MORIYAMA, YOSHIAKI, KOBAYASHI, OSAMU, SAITO, HIDEAKI, KINOSHITA, YASUTAMI   +6 more
openaire   +3 more sources