Results 61 to 70 of about 22,483 (254)

Percussion hemoglobinuria - a novel term for hand trauma-induced mechanical hemolysis: a case report

Journal of Medical Case Reports, 2011
Introduction Extracorpuscular hemolysis caused by mechanical trauma has been well described in relation to lower extremity use, such as in soldiers and runners.
Hariharan Sundaram, Hari Parameswaran N, Cohen Eric P, Bresnahan Barbara A, Vasudev Monica, Vasudev Brahm S   +5 more
doaj   +1 more source

Hemolysis Detected Following the Preparation and Collection of Blood in a Porcine Model Using a Syringe‐Based Aspiration Thrombectomy System for Autotransfusion

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Autologous transfusion of filtered, unwashed blood is a technique to mitigate the effects of blood loss during mechanical thrombectomy, but the degree of hemolysis resulting from this approach and guidance for blood return in this setting is not well understood.
Suhail Dohad, Mohammed M. Hoque, Jonathan H. Waters, Marc Salhanick   +3 more
wiley   +1 more source

Paroxysmal nocturnal hemoglobinuria clone in 103 Brazilian patients: diagnosis and classification

Revista Brasileira de Hematologia e Hemoterapia, 2015
Background: Paroxysmal nocturnal hemoglobinuria is an acquired chronic hemolytic ane- mia, which often manifests as peripheral blood cytopenias and thrombosis. Objective: The aim of this study is to describe a Brazilian population of paroxysmal nocturnal
Ana Paula de Azambuja, Mariester Malvezzi, Marco Antonio Bitencourt, Michel Michels Oliveira, Larissa Alessandra Medeiros, Ricardo Pasquini   +5 more
doaj   +1 more source

Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria

Clinical Pharmacokinetics, 2020
Background Cemdisiran, an N -acetylgalactosamine (GalNAc) conjugated RNA interference (RNAi) therapeutic, is currently under development for the treatment of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.
P. Badri, Xuemin Jiang, A. Borodovsky, N. Najafian, Jae Kim, Valerie A. Clausen, V. Goel, B. Habtemariam, G. Robbie   +8 more
semanticscholar   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Paroxysmal nocturnal hemoglobinuria [PDF]

Vnitřní lékařství, 2018
Paroxysmal nocturnal hemoglobinuria (PNH) results from a deficiency in inhibitors of activated complement. This lack leads to complement mediated intravascular hemolysis, to activation of coagulation system with increased risk of thrombotic complications and to various degree of bone marrow failure.
openaire   +2 more sources

Peripheral versus Marrow Lipidomics in Patients with Severe Aplastic Anemia: Potential Indicators for Early Immunosuppressive Treatment Response

Lipids, EarlyView.
ABSTRACT This study aimed to explore the differences of peripheral blood (PB) and bone marrow serum lipidomic profiles in severe aplastic anemia (SAA) patients and their significance in predicting earlier immunosuppressive therapy (IST) response. A cohort of 11 newly diagnosed SAA patients and 15 healthy controls were enrolled between June 2020 and ...
Zexing Sun, Yilei Hong, Yaonan Hong, Chuanao Xin, Qi Liu, Huijin Hu, Yingying Shen, Ying Chen, Shan Liu, Yiping Shen, Yuhong Zhou, Dijiong Wu   +11 more
wiley   +1 more source

Frequency of paroxysmal nocturnal hemoglobinuria in patients attended in Belém, Pará, Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: Paroxysmal nocturnal hemoglobinuria is a hematological disease with complex physiopathology. It is genetically characterized by a somatic mutation in the PIG-A gene (phosphatidylinositol glycan anchor biosynthesis, class A), in which the best
Lacy Cardoso de Brito Junior, Maria do Socorro de Oliveira Cardoso, Euzamar Gaby Rocha, Herika Anijar, Mariana Cunha, João Carlos Pina Saraiva   +5 more
doaj   +1 more source

Phase II study of the triple combination of rabbit ATG, ciclosporin and eltrombopag in patients with transfusion‐dependent aplastic anaemia: West Japan Hematology Study Group (W‐JHS) AA02 trial

British Journal of Haematology, EarlyView.
Summary The efficacy of a triple combination of rabbit anti‐human thymocyte immunoglobulin (rATG), ciclosporin and eltrombopag (EPAG) was prospectively evaluated in patients with severe or transfusion‐dependent non‐severe aplastic anaemia (SAA) across 29 institutions in Japan. Sixty patients were enrolled, of whom 48 had SAA. The primary end‐point, the
Fumi Nakamura, Ken Ishiyama, Ritsuro Suzuki, Hiroyuki Maruyama, Yasushi Onishi, Kensuke Usuki, Hideo Koh, Katsuto Takenaka, Ryunosuke Saiki, Seishi Ogawa, Kana Matsumoto, Takuto Takahashi, Kazuyoshi Hosomichi, Yoshitaka Zaimoku, Kenichi Yoshimura, Itaru Matsumura, Koichi Akashi, Shinji Nakao   +17 more
wiley   +1 more source

Primaquine-induced hemoglobinuria: a case report of a G6PD deficient malaria patient with Mahidol trait from Bandarban, Bangladesh

Frontiers in Malaria
We report a case of Primaquine (PQ) induced hemoglobinuria in a patient with the glucose-6-phosphate dehydrogenase (G6PD) Mahidol variant from Bandarban, Bangladesh.
Md Fahad Zamil, Ching Swe Phru, Anamul Hasan, Afrida Tabassum Trina, Mohammad Shahbaz, Shahrear Tanvir Ahmed, Mohammad Sharif Hossain, Mohammad Shafiul Alam   +7 more
doaj   +1 more source