Results 71 to 80 of about 13,040 (222)

Telomere length in paroxysmal nocturnal hemoglobinuria correlates with clone size

, 2007
OBJECTIVE: To study if telomere length can be used as a surrogate marker for the mitotic history in normal and affected hematopoietic cells from patients with paroxysmal nocturnal hemoglobinuria (PNH).
Young, Neal S, Lansdorp, Peter M, Baerlocher, Gabriela M, Sloand, Elaine M   +3 more
core   +1 more source

Intoxicação espontânea e experimental por Brachiaria radicans (tanner-grass) em bovinos Natural and experimental poisoning by Brachiaria radicans (tanner grass) in cattle

Pesquisa Veterinária Brasileira, 2010
Brachiaria radicans (tanner-grass,) cresce bem em solos úmidos. Em Santa Catarina é encontrada principalmente nas regiões dos vales dos rios Tubarão e Itajaí.
Aldo Gava, Márcia Regina Simone de Deus, José Volni Branco, Ademir José Mondadori, Angelica Barth   +4 more
doaj   +1 more source

Iptacopan monotherapy resulted in increased hemoglobin level in patients with PNH and hemoglobin ≥10 g/dL after anti‐C5 therapy

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Patients with paroxysmal nocturnal hemoglobinuria (PNH) on anti‐C5 often experience extravascular hemolysis with anemia. Iptacopan, the first oral proximal complement inhibitor targeting factor B, has shown efficacy and safety in PNH patients. APPULSE‐PNH (NCT05630001), a phase 3b, single‑arm, open‐label trial, enrolled adult patients with PNH
Austin Kulasekararaj, Flore S. de Fontbrune, Anna Gaya, Ilene Weitz, David J. Kuter, Bhumika J. Patel, David J. Araten, Abhay Singh, Jun H. Jang, Richard J. Kelly, Eros Di Bona, Michael Loschi, Vinod Pullarkat, Jörg Schubert, Rosario Notaro, Mustafa N. Yenerel, Joan Beckman, Nicolas Blin, Irina Murakhovskaya, Jens Panse, Eloy Roman, Alexander Röth, Hubert Schrezenmeier, Srinivas Tantravahi, Régis P. de Latour, Navin Mahajan, Luca Monaco, Tao Ding, Tomasz Lawniczek, Philippe Ferber, Marion Dahlke, Antonio M. Risitano   +31 more
wiley   +1 more source

The pathophysiology of paroxysmal nocturnal hemoglobinuria and treatment with eculizumab

, 2009
Richard Kelly1, Stephen Richards1, Peter Hillmen1, Anita Hill21Institute of Oncology, St. James’s University Hospital, Leeds, UK; 2Department of Haematology, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UKAbstract: Paroxysmal ...
Stephen Richards, Peter Hillmen, et al, Richard Kelly   +3 more
core  

Evans' syndrome in paroxysmal nocturnal hemoglobinuria.

, 1985
We describe the first case of paroxysmal nocturnal hemoglobinuria with Evans' syndrome. The immunohematological studies of this patient, a 27-year-old man, revealed the presence of red cell and platelet autoantibodies, related to an episode of anemia and
GIRELLI, Gabriella, Conti L, Iurlo A, Gandolfo GM   +3 more
core   +1 more source

Paroxysmal Nocturnal Hemoglobinuria

Current Opinion in Hematology, 2012
The aim is to report on recent observations related to the natural history of paroxysmal nocturnal hemoglobinuria (PNH) and to review new therapeutic strategies for controlling the hemolysis of PNH.This review focuses on studies designed to characterize the long-term outcome of patients with PNH treated with eculizumab and to define the relationship ...
openaire   +6 more sources

Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents

, 2008
Antonio M Risitano, Bruno RotoliHematology, Department of Biochemistry and Medical Biotechnologies, Federico II University of Naples, ItalyAbstract: Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal non-malignant hematological disease characterized ...
RISITANO, ANTONIO MARIA, Bruno Rotoli, Antonio M Risitano, Rotoli B.   +3 more
core  

Hemoglobinúria paroxística noturna e gravidez Paroxysmal nocturnal hemoglobinuria in pregnancy

Revista Brasileira de Ginecologia e Obstetrícia, 2004
A hemoglobinúria paroxística noturna é doença rara, causada por mutação adquirida de um gene no sistema hematopoético com 16-18% dos casos diagnosticados durante a gravidez.
Marcelo Luís Nomura, Fernanda Garanhani de Castro Surita, Mary Angela Parpinelli, Egle Cristina Couto Carvalho, Renato Passini Júnior   +4 more
doaj   +1 more source

Paroxysmal nocturnal hemoglobinuria and pregnancy before the eculizumab era: the French experience

Haematologica, 2011
Background Pregnancy in women with paroxysmal nocturnal hemoglobinuria is rare, with few reports on maternal and fetal mortality rates.Design and Methods A specific questionnaire designed to solicit data on pregnancies in women with paroxysmal nocturnal ...
Sophie de Guibert, Régis Peffault de Latour, Nathalie Varoqueaux, Hélène Labussière, Bernard Rio, Dominique Jaulmes, Jean-Richard Eveillard, Stéphanie Dulucq, Anne-Marie Stoppa, Didier Bouscary, François Girodon, Bernard Bonnotte, Djamila Laskri, Gérard Socié, Thierry Lamy   +14 more
doaj   +1 more source

Development of paroxysmal nocturnal hemoglobinuria in CALR-positive myeloproliferative neoplasm

, 2016
Yarden S Fraiman,1,2 Nathan Cuka,3 Denise Batista,3 Milena Vuica-Ross,3 Alison R Moliterno4 1Department of Pediatrics, Harvard Medical School, 2Department of Pediatrics, Boston University School of Medicine, Boston, MA, 3Department of Pathology ...
Cuka N, Batista D, Moliterno AR, Fraiman YS, Vuica-Ross M   +4 more
core