Results 71 to 80 of about 22,402 (256)

March hemoglobinuria progressed to acute kidney injury after kendo practice: a case report

BMC Nephrology, 2022
Background March hemoglobinuria is caused by a hemolytic mechanism due to transient hematuria after physical exercise which, although rare, may lead to acute kidney injury.
Maiko Yoshida, Hitoshi Suzuki, Sho Hamaguchi, Masako Iwasaki, Hiromitsu Fukuda, Hisatsugu Takahara, Shigeki Tomita, Yusuke Suzuki   +7 more
doaj   +1 more source

Clonal Dynamics of GPI‐Deficient Cells in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH): A Retrospective Follow‐Up Analysis

European Journal of Haematology, EarlyView.
ABSTRACT This retrospective, single‐center study aimed to characterize clonal dynamics of GPI‐deficient cells in patients with paroxysmal nocturnal hemoglobinuria (PNH) or PNH/aplastic anemia (AA) syndrome using multiparameter flow cytometry including FLAER.
Sandra M. Frey, Friederike Poppenborg, Ute Schmücker, Nicole Preising, H. Christian Reinhardt, Alexander Röth, Ferras Alashkar   +6 more
wiley   +1 more source

Expert consensus on the management of pharmacodynamic breakthrough-hemolysis in treated paroxysmal nocturnal hemoglobinuria

Hematology
Introduction: Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired, non-malignant hematologic disease characterized by complement-mediated hemolysis (with or without hemoglobinuria), fatigue, increased susceptibility to thrombosis, and bone ...
D. Dingli, Carlos De Castro, Jamie L. Koprivnikar, A. Kulasekararaj, Jaroslaw P. Maciejewski, B. Mulherin, J. Panse, V. Pullarkat, A. Röth, J. Shammo, L. Terriou, Ilene Weitz, Irina Yermilov, S. Gibbs, M. Broder, David O Beenhouwer, D. Kuter   +16 more
semanticscholar   +1 more source

Outbreak of simultaneous poisoning by Froelichia humboldtiana (Roem. & Schult.) Seub and Indigofera suffruticosa in ruminants in the Sertão of Pernambuco, Brazil

Arquivo Brasileiro de Medicina Veterinária e Zootecnia
The occurrence of outbreak of poisoning due to a combination of plants is uncommon worldwide, and there are no records of similar cases in Brazil. An outbreak of poisoning by Froelichia humboldtiana and Indigofera suffruticosa in ruminants in the Sertão ...
C.A.O. Oliveira, J.K.A. Melo, D.C. Silva, K.C. Rocha, S.F. Lira, W.F. Souza, L.C.F. Baptista-Filho, T.R.R. Ramos   +7 more
doaj   +1 more source

Expert Consensus on the Diagnosis and Monitoring of Paroxysmal Nocturnal Hemoglobinuria (PNH): An Algorithmic Approach in an Era of New Treatments

European Journal of Haematology, EarlyView.
ABSTRACT Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder caused by a defect of glycosylphosphatidyl‐anchored proteins, leading to an uncontrolled complement‐mediated hemolysis. The advent of complement inhibitors in clinical practice radically changed patients' outcomes and survival.
Bruno Fattizzo, Monia Marchetti, Elisa Cannizzo, Arianna Gatti, Massimo Geuna, Anna Paola Iori, Maddalena Raia, Simona Sica, Francesco Buccisano   +8 more
wiley   +1 more source

Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? A Position Paper From the SAAWP of the EBMT

Frontiers in Immunology, 2019
The treatment of paroxysmal nocturnal hemoglobinuria has been revolutionized by the introduction of the anti-C5 agent eculizumab; however, eculizumab is not the cure for Paroxysmal nocturnal hemoglobinuria (PNH), and room for improvement remains. Indeed,
A. Risitano, S. Marotta, Patrizia Ricci, L. Marano, C. Frieri, F. Cacace, M. Sica, A. Kulasekararaj, R. Calado, P. Scheinberg, R. Notaro, Régis Peffault de Latour   +11 more
semanticscholar   +1 more source

C3 inhibition with pegcetacoplan in subjects with paroxysmal nocturnal hemoglobinuria treated with eculizumab

American journal of hematology/oncology, 2020
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired, life‐threatening hematologic disease characterized by chronic complement‐mediated hemolysis and thrombosis.
Carlos de Castro, F. Grossi, I. Weitz, J. Maciejewski, Vivek Sharma, E. Roman, R. Brodsky, L. Tan, Carl Di casoli, D. El Mehdi, Pascal Deschatelets, C. Francois   +11 more
semanticscholar   +1 more source

Hemolysis & Hemoglobinuria Are Associated With Chronic Kidney Disease In Patients With Sickle Cell Anemia

, 2014
To evaluate the association between hemoglobinuria and chronic kidney disease (CKD) in sickle cell anemia (SCA), we analyzed 356 adult hemoglobin SS or Sβo thalassemia patients from the University of Illinois at Chicago and 439 from the multi-center Walk-
Santosh Saraf (7951145)
core   +6 more sources

Frequency of paroxysmal nocturnal hemoglobinuria in patients attended in Belém, Pará, Brazil

Revista Brasileira de Hematologia e Hemoterapia, 2011
BACKGROUND: Paroxysmal nocturnal hemoglobinuria is a hematological disease with complex physiopathology. It is genetically characterized by a somatic mutation in the PIG-A gene (phosphatidylinositol glycan anchor biosynthesis, class A), in which the best
Lacy Cardoso de Brito Junior, Maria do Socorro de Oliveira Cardoso, Euzamar Gaby Rocha, Herika Anijar, Mariana Cunha, João Carlos Pina Saraiva   +5 more
doaj   +1 more source

Australian consensus recommendations for the management of increased meningococcal infection risk in adults with neurological diseases treated with complement inhibitors

Internal Medicine Journal, EarlyView.
Abstract Complement inhibitor therapy carries a risk of serious infections, including meningococcal disease. Here we provide evidence‐based recommendations and expert consensus for immunisation and prophylactic treatment of patients receiving, or planning to receive, complement inhibitors for neurological conditions in the Australian setting.
Katherine A. Buzzard, Michael Barnett, Heidi Beadnall, Mirasol Forcadela, Lesley‐Ann Hall, Victoria G. Hall, Todd Hardy, Danny Hsu, Paul Kinsella, Mastura Monif, Sudarshini Ramanathan, Stephen W. Reddel, Sean Riminton, Douglas F. Johnson   +13 more
wiley   +1 more source