Results 61 to 70 of about 10,802 (181)

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Anemia and Patient‐Reported Outcomes in Patients With Paroxysmal Nocturnal Hemoglobinuria: A Real‐World Observational Study

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Introduction Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematologic disorder characterized by complement‐mediated hemolysis, thrombosis, bone marrow failure, and anemia. Although current treatments improve outcomes, patients still experience hemolysis and could remain anemic with a negative impact on quality of life (QoL).
Esther Natalie Oliva, Antonio M Risitano, Eros Di Bona, Alessandro Maria Vannucchi, Ilaria Maria Dellfino, Antonio De Vivo, Valentina Giai, Rosario Notaro, Giuseppe Iannì, Eloise Beggiato, Simona Sica, Gaetano La Barba, Sneha Balakrishnan, Joanna Large, Tanuja Thavarajah, Simona Raso, Raffaele Fontana, Wilma Barcellini, Bruno Fattizzo, Roochi Trikha, Luana Marano, Jens Panse, Austin G Kulasekararaj   +22 more
wiley   +1 more source

Intoxicação crônica por cobre em ovinos: conduta para o diagnóstico conclusivo Chronic copper toxicities in sheep: conduct for diagnostic confirmation

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2013
Descreveram-se os sinais clínicos e achados anatomopatológicos da intoxicação crônica por cobre em um ovino da raça Texxel e definiu-se a conduta diagnóstica correta para confirmação da enfermidade.
M.P. Miguel, M.A. Souza, P.H.J. Cunha, G.L. Costa, L.J. Abud   +4 more
doaj  

Early Hemolysis, Myolysis and Renal Stress Following Pentaspline Pulsed Field Versus Radiofrequency Ablation of Atrial Fibrillation

European Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.
Serial biomarker assessment in 40 patients undergoing first‐time pulmonary vein isolation showed greater hemolysis and myocardial myolysis after FARAPULSE pentaspline single‐shot pulsed field ablation than after radiofrequency ablation. Myoglobin changes were associated with transient changes in renal function, albeit these exploratory correlations do ...
Paul Felix Harbich, Lisa Auer, Florian Tinhofer, Achim Leo Burger, Tobias Eberl, Patrick Weltler, Stephan Dobner, Alexander Geppert, Kurt Huber, Christoph Clemens Kaufmann   +9 more
wiley   +1 more source

Case-Control Study of Parturient Hemoglobinuria in Buffaloes [PDF]

Pakistan Veterinary Journal, 2012
Population based case control study of parturient hemoglobinuria was conducted in District Chakwal during April 2009 to January 2011 for quantification of epidemiological risk factors associated with condition.
Altaf Mahmood*, Muhammad Athar Khan, Muhammad Younus1, Muhammad Arif Khan2, Hafiz Javed Iqbal3 and Abdul Ahad4
doaj  

Concurrent Loss of PIGA and ZRSR2 in a Patient With Paroxysmal Nocturnal Hemoglobinuria and Myelodysplastic Neoplasm

International Journal of Laboratory Hematology, EarlyView.
Fatma AlBulushi, Eric McGinnis
wiley   +1 more source

Short‐Course Low‐Dose Primaquine for Radical Cure in G6PD‐Normal Patients in the Pre‐Elimination Context of Nepal

Tropical Medicine &International Health, Volume 31, Issue 8, Page 1028-1034, August 2026.
ABSTRACT Background Plasmodium vivax remains a challenge for malaria elimination in Nepal due to its ability to relapse. Radical cure with primaquine is effective but limited by poor adherence to the standard 14‐day low‐dose regimen. In 2022, the WHO recommended administering the same total dose (3.5 mg/kg) over 7 days to improve adherence.
Prakash Ghimire, Gokarna Dahal, Nabaraj Adhikari, Komal Raj Rijal, Sanjib Adhikari, Megha Raj Banjara, Hellen Mnjala, Grant Lee, Sophie Weston, Angela Rumaseb, Anjana Rai, Benedikt Ley, Mohammad Sharif Hossain, Julie A. Simpson, Megha Rajasekhar, Bipin Adhikari, Ric N. Price, Bibek K. Lal, Kamala Thriemer   +18 more
wiley   +1 more source

Paroxysmal Nocturnal Hemoglobinuria

Current Opinion in Hematology, 2012
The aim is to report on recent observations related to the natural history of paroxysmal nocturnal hemoglobinuria (PNH) and to review new therapeutic strategies for controlling the hemolysis of PNH.This review focuses on studies designed to characterize the long-term outcome of patients with PNH treated with eculizumab and to define the relationship ...
openaire   +6 more sources

Intoxicação espontânea e experimental por Brachiaria radicans (tanner-grass) em bovinos Natural and experimental poisoning by Brachiaria radicans (tanner grass) in cattle

Pesquisa Veterinária Brasileira, 2010
Brachiaria radicans (tanner-grass,) cresce bem em solos úmidos. Em Santa Catarina é encontrada principalmente nas regiões dos vales dos rios Tubarão e Itajaí.
Aldo Gava, Márcia Regina Simone de Deus, José Volni Branco, Ademir José Mondadori, Angelica Barth   +4 more
doaj   +1 more source

Hemoglobinúria paroxística noturna e gravidez Paroxysmal nocturnal hemoglobinuria in pregnancy

Revista Brasileira de Ginecologia e Obstetrícia, 2004
A hemoglobinúria paroxística noturna é doença rara, causada por mutação adquirida de um gene no sistema hematopoético com 16-18% dos casos diagnosticados durante a gravidez.
Marcelo Luís Nomura, Fernanda Garanhani de Castro Surita, Mary Angela Parpinelli, Egle Cristina Couto Carvalho, Renato Passini Júnior   +4 more
doaj   +1 more source