Results 81 to 90 of about 22,402 (256)

Anemia hemolítica em bovinos de corte em sistema de criação extensiva em Mato Grosso e Rondônia

Pesquisa Veterinária Brasileira
RESUMO: Casos de anemia hemolítica em bovinos de corte em sistema de criação extensiva em Mato Grosso e Rondônia são acompanhados desde 2008. Os animais acometidos apresentam fraqueza, mucosas pálidas ou ictéricas, urina enegrecida, depressão e anorexia.
Leilane A.S. Rondelli, Marciel Becker, Flávio H.B. Caldeira, Marlon Ribeiro, Fernando H. Furlan, Edson M. Colodel, Caroline A. Pescador, Nadia A.B. Antoniassi   +7 more
doaj   +1 more source

Mapping of C5‐Blocking Monoclonal Antibodies Reveals New C5 Inhibitory Epitopes and Novel Modes of C5 Inhibition

Immunology, EarlyView.
We identify four distinct C5 inhibitory epitopes, including two novel antibodies that selectively block membrane attack complex (MAC) assembly while preserving C5 cleavage and C5a generation. These findings establish selective MAC inhibition as a new therapeutic strategy for complement‐mediated diseases.
Rebekah Sian Cooke, Kok Yung Lee, Georgina Elizabeth Menzies, Masashi Mizuno, Bryan Paul Morgan, Wioleta Milena Zelek   +5 more
wiley   +1 more source

Laboratory Changes Supporting a Diagnosis of Immune‐Mediated Anemia in Cats With Initial Suspicion of Progressive Feline Leukemia Virus

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Progressive feline leukemia virus (FeLV) infection and anemia of suspected immune‐mediated origin (ASIMO) are associated with similar hematologic abnormalities, including anemia, neutropenia, and lymphocytosis. Cats with ASIMO may test positive for FeLV using point‐of‐care (POC) ELISA tests.
Nicholas Kelly, Katie McCallum, Will Bayton, Tyler Willard, Cassia Hare   +4 more
wiley   +1 more source

Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome

Haematologica, 2017
Paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome are diseases of excess activation of the alternative pathway of complement that are treated with eculizumab, a humanized monoclonal antibody against the terminal complement ...
Xuan Yuan, Eleni Gavriilaki, Jane A. Thanassi, Guangwei Yang, Andrea C. Baines, Steven D. Podos, Yongqing Huang, Mingjun Huang, Robert A. Brodsky   +8 more
doaj   +1 more source

THE MALARIAL PARASITE AND HEMOGLOBINURIA [PDF]

Southern Medical Journal, 1913
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openaire   +2 more sources

Use of Intralipid Therapy and Therapeutic Plasma Exchange in the Management of Cholecalciferol Rodenticide Exposure in a Dog: A Case Report

Journal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To describe the presentation and outcome of a case of suspected cholecalciferol rodenticide intoxication managed with both intralipid emulsion (ILE) and therapeutic plasma exchange (TPE). Case Summary A 3‐year‐old, neutered female, crossbreed dog presented for acute‐onset vomiting and lethargy after suspected exposure to ...
Tanvi A. Kamat, Kara D. Altman, Emma Donnelly, Neus Elias Santo‐Domingo   +3 more
wiley   +1 more source

Eltrombopag Added to Standard Immunosuppressive Treatment as Front‐Line Therapy for Severe Aplastic Anemia: Long‐Term Outcomes of the Phase‐3 Randomized Superiority EBMT‐SAAWP RACE Study

American Journal of Hematology, Volume 101, Issue 10, Page 2520-2532, October 2026.
ABSTRACT The RACE study (NCT02009747) compared horse antithymocyte globulin (hATG) plus cyclosporine A (CsA) ± eltrombopag as initial immunosuppressive treatment (IST) for severe aplastic anemia. Here we report the final 2‐year analysis of this prospective randomized phase III study.
Antonio M. Risitano, Simona Iacobelli, Austin Kulasekararaj, Marleen van Os, Sofie R. Terwel, Joe Tuffnell, Brian Piepenbroek, Morag Griffin, Constantijn J. M. Halkes, Christian Recher, Fiorenza Barraco, Edouard Forcade, Juan Carlos Vallejo, Beatrice Drexler, Jean‐Baptiste Mear, Roochi Trikha, Shreyans Gandhi, Anna Maria Raiola, L. G. M. Daenen, Marco R. de Groot, Etienne Daguindau, Erfan Nur, Wilma Barcellini, Nigel H. Russell, Louis Terriou, Anna Paola Iori, Walter Barberi, Anna Sureda, Isabel Sánchez‐Ortega, Blanca Xicoy, Isidro Jarque, James Cavenagh, Flore Sicre de Fontbrune, Camilla Frieri, Talha Munir, Jennifer M. L. Tjon, Suzanne Tavitian, Aline Praire, Laurence Clement, Florence Rabian, Luana Marano, Anita Hill, Elena Palmisani, Petra Muus, Serena Marotta, Fabiana Cacace, Marica Laurino, Jakob R. Passweg, Gérard Socié, Ghulam J. Mufti, Carlo Dufour, Régis Peffault de Latour, Severe Aplastic Anaemia Working Party of the EBMT   +52 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria

Clinical Pharmacokinetics, 2020
Background Cemdisiran, an N -acetylgalactosamine (GalNAc) conjugated RNA interference (RNAi) therapeutic, is currently under development for the treatment of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.
P. Badri, Xuemin Jiang, A. Borodovsky, N. Najafian, Jae Kim, Valerie Clausen, Varun Goel, B. Habtemariam, G. Robbie   +8 more
semanticscholar   +1 more source

Analysis of efficacy and safety of transarterial embolization sequential microwave ablation for hepatic hemangioma

International Journal of Hyperthermia
Purpose To evaluate the efficacy and safety of transarterial embolization (TAE) sequential microwave ablation (MWA) for hepatic hemangioma (HH).Methods This single-center retrospective study included 122 patients with 134 HHs treated from 2013 to 2024 ...
Yixuan An, Ningning Lu, Liang Ma, Wenfeng Gao, Ning He, Xiaozhen Yang, Chunwang Yuan   +6 more
doaj   +1 more source

Evaluation of Hemolysis Risk, Renal Function, and Safety Among Two Pulsed Field Ablation Systems: A Systematic Review and Meta‐Analysis

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
Pentaspline systems were associated with more pronounced laboratory markers of hemolysis, although clinically significant renal dysfunction remained uncommon and evidence regarding clinical consequences remains limited. ABSTRACT This study investigated the hemolysis risk, renal, and safety outcomes between two pulsed field ablation (PFA) systems.
Abdalrahman Al‐Slaimieh, Ibrahim Ghayada, Rand Al‐Huneidy, Mohammad Shahin, Khaled Abukhalaf, Waleed Alomari, Khaled Marwa, Saeed Abdel Kamel, Yahya Almazaraa, Mohammad Hajjiri, Abdallah Al‐Ani   +10 more
wiley   +1 more source