Results 91 to 100 of about 22,402 (256)

Technical advances in flow cytometry-based diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria

Einstein (São Paulo)
Objective: To discuss the implementation of technical advances in laboratory diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria for validation of high-sensitivity flow cytometry protocols. Methods: A retrospective study based on analysis of
Rodolfo Patussi Correia, Laiz Cameirão Bento, Ana Carolina Apelle Bortolucci, Anderson Marega Alexandre, Andressa da Costa Vaz, Daniela Schimidell, Eduardo de Carvalho Pedro, Fabricio Simões Perin, Sonia Tsukasa Nozawa, Cláudio Ernesto Albers Mendes, Rodrigo de Souza Barroso, Nydia Strachman Bacal   +11 more
doaj   +1 more source

Paroxysmal cold hemoglobinuria

Kazan medical journal, 2021
Paroxysmal cold hemoglobinuria, first described by Dresler in 1854, is characterized by the fact that after cooling a chill sets in and the temperature rises to 39-40 with all the sensations accompanying this state. Then there are pains in the lumbar region and in the abdomen, frequent urge to urinate with cramps, nausea, vomiting.
openaire   +3 more sources

Pegcetacoplan Delivers Real‐World Therapeutic Benefits and Reduces Disease Burden for Patients With Paroxysmal Nocturnal Haemoglobinuria: A Systematic Literature Review of Pegcetacoplan Real‐World Clinical and Patient‐Reported Outcomes

European Journal of Haematology, Volume 117, Issue 4, Page 799-813, October 2026.
ABSTRACT Aims Paroxysmal nocturnal haemoglobinuria (PNH) is an ultra‐rare, acquired, non‐malignant haematological disorder that, if left untreated, can lead to significant morbidity. This systematic literature review (SLR) summarized real‐world evidence (RWE) for pegcetacoplan, a complement 3/3b inhibitor (C3i) available since 2021.
Juan Carlos Vallejo Llamas, Koo Wilson, Zalmai Hakimi, Vikte Lionikaite, Elisabetta Metafuni   +4 more
wiley   +1 more source

Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria

Haematologica, 2011
Background A deficiency of specific glycosylphosphatidyl inositol-anchored proteins in paroxysmal nocturnal hemoglobinuria may be responsible for most of the clinical features of this disease, but some functional consequences may be indirect. For example,
Anna M. Jankowska, Hadrian Szpurka, Mark Calabro, Sanjay Mohan, Andrew E. Schade, Michael Clemente, Roy L. Silverstein, Jaroslaw P. Maciejewski   +7 more
doaj   +1 more source

Early‐stage crystalluria‐associated cystitis in a horse: Diagnostic value of serial urine sediment examination

Equine Veterinary Education, Volume 38, Issue 10, Page e690-e697, October 2026.
Summary Calcium carbonate crystals are commonly observed in equine urine; however, crystalluria without urolith formation rarely results in clinically significant disease. A 4‐year‐old Japanese Sport Horse developed recurrent haematuria accompanied by the presence of numerous angular calcium carbonate crystals. Discontinuing the calcium supplementation
R. Sato, S. Imai, A. Yamazaki, T. Miyazaki   +3 more
wiley   +1 more source

Paroxysmal nocturnal hemoglobinuria: current treatments and unmet needs

Journal of Managed Care & Specialty Pharmacy, 2020
The current standard of care for paroxysmal nocturnal hemoglobinuria (PNH) are the C5 inhibitors eculizumab and ravulizumab, both monoclonal antibodies designed to target the complement protein C5, thereby preventing its cleavage and the formation of the
M. Bektas, C. Copley-Merriman, Shahnaz Khan, S. Sarda, J. Shammo   +4 more
semanticscholar   +1 more source

Concurrent Loss of PIGA and ZRSR2 in a Patient With Paroxysmal Nocturnal Hemoglobinuria and Myelodysplastic Neoplasm

International Journal of Laboratory Hematology, EarlyView.
Fatma AlBulushi, Eric McGinnis
wiley   +1 more source

Assessment of the Performance of Siemens Scopio Digital Morphology on Bone Marrow Aspirates in Onco‐Hematology

International Journal of Laboratory Hematology, Volume 48, Issue 5, Page 1000-1007, October 2026.
ABSTRACT Objectives Digital morphology (DM) systems assisted by artificial intelligence are increasingly being introduced into hematology laboratories; however, data on their performance in routine clinical practice for bone marrow aspirates (BMA) remain limited.
Gina Zini, John Marra, Elena Rossi, Silvia Bellesi, Nicoletta Pelliccioni, Giuseppe d'Onofrio, Patrizia Chiusolo   +6 more
wiley   +1 more source

Laboratory studies for paroxysmal nocturnal hemoglobinuria, with emphasis on flow cytometry

Practical Laboratory Medicine, 2020
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired clonal hematopoietic stem cell disorder caused by somatic mutations in the PIG-A gene, leading to the production of blood cells with absent or decreased expression of ...
M. Lima
semanticscholar   +1 more source

Paroxysmal nocturnal hemoglobinuria clones in severe aplastic anemia patients treated with horse anti-thymocyte globulin plus cyclosporine

Haematologica, 2010
Background Clones of glycosylphosphatidylinositol-anchor protein-deficient cells are characteristic in paroxysmal nocturnal hemoglobinuria and are present in about 40–50% of patients with severe aplastic anemia.
Phillip Scheinberg, Michael Marte, Olga Nunez, Neal S. Young   +3 more
doaj   +1 more source