Results 111 to 120 of about 59,490 (296)

When the environment and mutations affect organ systems [PDF]

, 2017
Atypical hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy (TMA) with a genetic predisposition. Like other TMAs, it presents clinically with thrombocytopenia and microangiopathic hemolytic anemia, which is accompanied by disruption of
Abu Ghanimeh, Mouhanna, Abughanimeh, Omar, Qasem, Abdulraheem, Qasrawi, Ayman   +3 more
core   +1 more source

Atypical haemolytic-uraemic syndrome caused by factor H mutation: case report and new management strategies in children [PDF]

, 2012
Atypical haemolytic uraemic syndrome is causedby alternative complement pathway dysregulation. It has recently been recognised that most cases are due to genetic factors and a growing list of mutations has been described.
Araújo, L., Barbot, J., Costa, T., Faria, M., Mota, C., Rocha, L.   +5 more
core  

Anti factor H autoantibodies block C-terminal recognition function of factor H in hemolytic uremic syndrome [PDF]

, 2007
The atypical form of the kidney disease hemolytic uremic syndrome (aHUS) is associated with defective complement regulation. In addition to mutations in complement regulators, factor H (FH)-specific autoantibodies have been reported for aHUS patients ...
Dahse, H. M., Hoyer, P. F., Józsi, Mihály, Liu, W. S., Strobel, S.   +4 more
core   +1 more source

Organ Crosstalk During Injury: Mechanisms of Lung–Kidney Interaction in Critical Illness

Comprehensive Physiology, Volume 15, Issue 6, December 2025.
Crosstalk between the lungs and kidneys may propagate multiorgan injury in critically ill patients. This review examines evidence of crosstalk between the lungs and kidneys after injury, focusing on translational and mechanistic studies. Pathophysiology and animal models of acute kidney injury (AKI) and acute respiratory distress syndrome (ARDS) are ...
Kathryn M. Sullivan, Kathleen D. Liu, Michael A. Matthay   +2 more
wiley   +1 more source

Thrombomodulin enhances complement regulation through strong affinity interactions with factor H and C3b-Factor H complex [PDF]

, 2016
Introduction Coagulation and complement systems are simultaneously activated at sites of tissue injury, leading to thrombin generation and opsonisation with C3b.
Baerga-Ortiz, Bajzar, Boehme, Bossi, Campbell, Conway, de Córdoba S, Delvaeye, Dragon-Durey, Esmon, Esmon, Esmon, Esparza-Gordillo, Faust, Fuentes-Prior, Gordon, Hakobyan, Hamad, Harris, Heurich, Hindmarsh, Honda, Huntington, Ikeda, Ito, Jokiranta, Kavanagh, Li, Light, Maga, Markiewski, Martinez-Barricarte, Mayer, Meri, Mizuno, Moll, Morgan, Mouksassi, Noris, Owen, Pangburn, Sadler, Sadler, Saito, Salem, Sawada, Schramm, Shental-Bechor, Suzuki, Tateishi, Tortajada, Udagawa, Vincent, Walport, Walport, Wu, Yada, Yamamoto, Zushi   +58 more
core   +2 more sources

Terminal Complement Inhibitor Eculizumab in Adult Patients With Atypical Hemolytic Uremic Syndrome: A Single-Arm, Open-Label Trial.

American Journal of Kidney Diseases, 2016
BACKGROUND Atypical hemolytic uremic syndrome (aHUS) is a rare genetic life-threatening disease of chronic uncontrolled complement activation leading to thrombotic microangiopathy (TMA) and severe end-organ damage.
F. Fakhouri, J. Campistol, J. Menne, E. Minetti, E. Rondeau, C. Bedrosian   +5 more
semanticscholar   +1 more source

Shiga toxin-producing Escherichia coli: A single-center, 11-year pediatric experience [PDF]

, 2014
The aim of this study was to identify the best practices for the detection of Shiga toxin-producing Escherichia coli (STEC) in children with diarrheal illness treated at a tertiary care center, i.e., sorbitol-MacConkey (SMAC) agar culture, enzyme ...
Burnham, Carey-Ann D, Schindler, Emily I, Sellenriek, Patricia, Storch, Gregory A, Tarr, Phillip I   +4 more
core   +2 more sources

Infection due to Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) presenting as ischemic colitis

IDCases, 2019
Infections due to Shiga toxin-producing enterohemorrhagic Escherichia coli (EHEC) are often mild and self-limiting, but more severe cases can develop into hemolytic uremic syndrome (HUS) and hemorrhagic colitis. This case report documents a sporadic case
Camille D. Tanquilut, Chin W. Jung, Allen W. Nelson, Sean K. Lau   +3 more
doaj   +1 more source

Complement regulator CD46: Genetic variants and disease associations [PDF]

, 2015
Membrane cofactor protein (MCP; CD46) is an ubiquitously expressed complement regulatory protein that protects host cells from injury by complement.
Atkinson, John P, Liszewski, M. Kathryn
core   +2 more sources

POS-004 ATYPICAL HEMOLYTIC UREMIC SYNDROME IN YOUNG FEMALE: CASE FOR DISCUSSION

, 2022
W.A.E.S. Elrewaihby
openalex   +1 more source