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Atypical hemolytic-uremic syndrome: current view and case report
Therapy, 2019Atypical hemolytic-uremic syndrome is a disease that primarily affects kidney function. This condition, which can occur at any age, causes abnormal blood clots (thrombi) to form in small blood vessels in the kidneys. These clots can cause serious medical
Malimon V.V. Malimon +4 more
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The Journal of Pediatrics, 1972
IN 1955 Gasser and his associates1 introduced the term hemolytie-uremic syndrome to describe 5 children with a fatal disease characterized by acute renal failure, hemolytic anemia and thrombocytopenia. They considered that the severe renal disease distinguished the disorder in their patients from the disorder called thrombotic thrombocytopenic purpura ...
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IN 1955 Gasser and his associates1 introduced the term hemolytie-uremic syndrome to describe 5 children with a fatal disease characterized by acute renal failure, hemolytic anemia and thrombocytopenia. They considered that the severe renal disease distinguished the disorder in their patients from the disorder called thrombotic thrombocytopenic purpura ...
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The hemolytic uremic syndromes
Current Opinion in Critical Care, 2005Recent studies have provided a better understanding of the molecular mechanisms responsible for hemolytic uremic syndromes. In this review, we summarize biochemical and genetic data that may lead to new clinical approaches.The structures and modes of action of Shiga toxins have been deciphered.
Jessica, Caprioli +2 more
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Atypical hemolytic uremic syndrome
Current Opinion in Hematology, 2010The last few years revealed a molecular distinction between thrombotic thrombocytopenic purpura, a disease characterized by a lack of ADAMTS13 activity, and atypical hemolytic uremic syndrome (aHUS), a disease of complement overactivation. Many different predisposing genetic factors resulting in complement overactivation have been described in aHUS ...
Kavanagh D, Goodship THJ
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Recurrent Hemolytic Uremic Syndrome
Clinical Pediatrics, 2002Hemolytic uremic syndrome (HUS) in children follows a diarrheal prodrome (D+) approximately 90% of the time, and recurrence due to enteric reinfection with Shiga toxin producing E. coli (e.g., 0157:H7) can occur but is rare. It is not well recognized that nondiarrheal (D-) recurrences can also follow an episode of D+ HUS; we report 2 unrelated females
Richard L, Siegler +2 more
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Anticomplement Treatment in Atypical and Typical Hemolytic Uremic Syndrome.
Seminars in hematology (Print), 2018The dissection of the pathogenic mechanisms of the various forms of the hemolytic uremic syndrome (HUS) has paved the way for the design of specific efficacious treatments.
F. Fakhouri, C. Loirat
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The Hemolytic Uremic Syndromes
1989This paper is about a number of disorders occurring in children and adults that, although they have different etiologies and variable clinical expression, share three constant features: acquired hemolytic anemia, thrombocytopenia and renal damage, and one common histological lesion mostly referred to as thrombotic microangiopathy, a term introduced by ...
W, Proesmans, R, Eeckels
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Atypical Hemolytic Uremic Syndrome
Pediatric Clinics of North America, 2018Atypical hemolytic uremic syndrome is a rare life-threatening disease of unregulated complement activation. Untreated, the prognosis is generally poor; more than one-half of patients die or develop end-stage renal disease within 1 year. Atypical hemolytic uremic syndrome is characterized by thrombotic microangiopathy with evidence of hemolysis ...
Bradley P. Dixon, Ralph A. Gruppo
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Postpartum hemolytic uremic syndrome
American Journal of Obstetrics and Gynecology, 1983A 22-year-old. gravida 1, para 1, abortus 1 woman was readmitted to the hospital with abdominal pain, vomiting, and bloody diarrhea of 2 days' duration. Pregnancy had been uncomplicated; blood pressure readings and urinalyses showed normal results. Labor and delivery at 39 weeks' gestation had been uncomplicated, and the patient had been discharged on ...
H W, Jones, C A, Bowker, R J, Diblasi
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Atypical Hemolytic–Uremic Syndrome
New England Journal of Medicine, 2009The hemolytic–uremic syndrome, which is characterized by nonimmune hemolytic anemia, thrombocytopenia, and renal impairment, occurs most frequently in young children. Most cases are secondary to infection with Escherichia coli O157:H7 and other Shiga-toxin–producing strains.
Marina, Noris, Giuseppe, Remuzzi
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