Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility. [PDF]
Micromachines (Basel), 2022 The potential use of nanomaterials in medicine offers opportunities for novel therapeutic approaches to treating complex disorders. For that reason, a new branch of science, named nanotoxicology, which aims to study the dangerous effects of nanomaterials
Yedgar S, Barshtein G, Gural A.
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Characterization of the Hemolytic Activity of Mastoparan Family Peptides from Wasp Venoms [PDF]
Toxins, 2023 Biologically active peptides have attracted increasing attention in research on the development of new drugs. Mastoparans, a group of wasp venom linear cationic α-helical peptides, have a variety of biological effects, including mast cell degranulation ...
Xiangdong Ye +10 more
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AMPDeep: hemolytic activity prediction of antimicrobial peptides using transfer learning. [PDF]
BMC Bioinformatics, 2022 Background Deep learning’s automatic feature extraction has proven to give superior performance in many sequence classification tasks. However, deep learning models generally require a massive amount of data to train, which in the case of Hemolytic ...
Salem M, Keshavarzi Arshadi A, Yuan JS.
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Brevibacillin 2V, a Novel Antimicrobial Lipopeptide With an Exceptionally Low Hemolytic Activity. [PDF]
Front Microbiol, 2021 Bacterial non-ribosomally produced peptides (NRPs) form a rich source of antibiotics, including more than twenty of these antibiotics that are used in the clinic, such as penicillin G, colistin, vancomycin, and chloramphenicol.
Zhao X +6 more
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In Vitro Probiotic Potential and Safety Evaluation (Hemolytic, Cytotoxic Activity) of Bifidobacterium Strains Isolated from Raw Camel Milk [PDF]
Microorganisms, 2020 The present study was designed to isolate Bifidobacterium strains from raw camel milk and to investigate their probiotic characteristics. Among 35 isolates, 8 were identified as Gram-positive, catalase negative, non-spore forming, non-motile and V or Y ...
Iqra Yasmin +11 more
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HAPPENN is a novel tool for hemolytic activity prediction for therapeutic peptides which employs neural networks. [PDF]
Sci Rep, 2020 The growing prevalence of resistance to antibiotics motivates the search for new antibacterial agents. Antimicrobial peptides are a diverse class of well-studied membrane-active peptides which function as part of the innate host defence system, and form ...
Timmons PB, Hewage CM.
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Hemolytic activity of Borrelia burgdorferi [PDF]
Infection and Immunity, 1992 Zones of beta-hemolysis occurred around colonies of Borrelia burgdorferi grown on Barbour-Stoenner-Kelly medium containing agarose and horse blood. Blood plates were inoculated with either the infective strain Sh-2-82 or noninfective strain B-31 in an overlay and incubated in a candle jar. Both strains of B. burgdorferi displayed beta-hemolysis after 1
Lisa Williams, F E Austin
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Identification of genetic determinants of hemolytic activity of Riemerella anatipestifer using random transposon mutagenesis [PDF]
Veterinary Research, 2021 Riemerella anatipestifer causes epizootic infectious disease in poultry resulting in serious economic losses especially to the duck industry. In our previous study, R. anatipestifer was found to lyse duck erythrocytes in vitro.
Bingqing Sun +9 more
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Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides. [PDF]
Sci Rep, 2020 The use of non-standard toxicity models is a hurdle in the early development of antimicrobial peptides towards clinical applications. Herein we report an extensive in vitro and in vivo toxicity study of a library of 24 peptide-based antimicrobials with ...
Greco I +8 more
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Peptide hemolytic activity analysis using visual data mining of similarity-based complex networks [PDF]
npj Systems Biology and ApplicationsPeptides are promising drug development frameworks that have been hindered by intrinsic undesired properties including hemolytic activity. We aim to get a better insight into the chemical space of hemolytic peptides using a novel approach based on ...
Kevin Castillo-Mendieta +7 more
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