Results 111 to 120 of about 11,283,851 (345)

A comparison of pneumolysin activity and concentration in vitro and in vivo in a rabbit endophthalmitis model

Clinical Ophthalmology, 2008
Melissa E Sanders1, Erin W Norcross1, Quincy C Moore III1, Chinwendu Onwubiko1, Lauren B King1, et al1Department of Microbiology; 2Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USAAbstract: The purpose of this ...
Melissa E Sanders, Erin W Norcross, Quincy C Moore III, Chinwendu Onwubiko, Lauren B King, et al   +5 more
doaj  

Synthesis and Hemolytic Activity of Bile Acid-Indole Bioconjugates Linked by Triazole. [PDF]

J Org Chem, 2023
Berdzik N, Koenig H, Mrówczyńska L, Nowak D, Jasiewicz B, Pospieszny T.   +5 more
europepmc   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

Inulin‐Based Oral Chemotherapy Modulates Gut Microbiota and Immune Microenvironment through Inhibition of Neutrophil Extracellular Trap Formation for Improving Cancer Therapy

Advanced Science, EarlyView.
Schematic representation of ZIF‐8@OXA@inulin for cancer immunotherapy. Synthesis of ZIF‐8@OXA@inulin. Augmentation of pyroptosis, regulation of gut microbiota, and inhibition of NETs formation by ZIF‐8@OXA@inulin‐mediated comprehensive strategy for antitumor immune response. ABSTRACT Despite the potential of chemoimmunotherapy against colorectal cancer
Zhenhao Li, Jiaqiang Jiang, Yuping Zhou, Xinyuan Mao, Haotian Wen, Zhian Chen, Yutong Wang, Cong Huang, Yanfeng Hu   +8 more
wiley   +1 more source

Saponin Rich Fractions (SRPs) from Soapwort Show Antioxidant and Hemolytic Activity

, 2013
The present study established baseline data on hemolytic and antioxidant capacity of saponin rich fractions (SRFs) of Gypsophila arrostii, G.pilulifera and G.simonii (Caryophyllaceae) naturally found in Turkey.
I. Arslan, A. Celi̇k
semanticscholar   +1 more source

Endogenous “Time Bomb” – Mislocalized Phospholipase A2 as a Critical Mediator of Ultra‐Rapid Mortality in Sepsis and Acute Lung Injury

Advanced Science, EarlyView.
Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang, Zhongxing Xu, Lin Wang, Xin Sui, Yuan Luo, Xiuli Zhao, Jun Yang, Yongan Wang   +7 more
wiley   +1 more source

Searching for Virulence Factors among Staphylococcus lugdunensis Isolates from Orthopedic Infections: Correlation of β-hemolysin, hemolysin III, and slush Genes with Hemolytic Activity and Synergistic Hemolytic Activity. [PDF]

Int J Mol Sci, 2023
Ravaioli S, Campoccia D, Mirzaei R, Mariani V, Bottau G, De Donno A, Montanaro L, Speziale P, Arciola CR.   +8 more
europepmc   +1 more source

Hemolytic activity of bioactive nanocomposites [PDF]

, 2012
Huge range of tested biomaterials in recent decades has emerged as an ideal scaffold for cell growth, but few have demonstrated clinical efficacy. Among them, synthetic hydroxyapatite (HAp, Ca10(PO4)6(OH)2) is the most promising because of its biocompatibility, bioactivity, and osteoconductivity.
Ajduković, Zorica, Ignjatović, Nenad L., Petrović, N., Najman, Stevo, Rajković, J., Kenić Marinković, D., Krstić, V., Uskoković, Dragan   +7 more
openaire   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

The Inhibition Effect and Mechanism of Litsea Cubeba Essential Oil on the Hemolytic Activity of Listeriolysin O

, 2023
Mei Bai, Jinming Dai, Changzhu Li, Wei Hu, Haiying Cui, Lin Lin   +5 more
openalex   +1 more source