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An update on the hemolytic uremic syndrome.
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Current Problems in Pediatrics, 1993
HUS is one of the most common causes of acute renal failure in childhood. D+ HUS is the most common form and usually follows an episode of hemorrhagic colitis due to VTEC or S. dysenteriae type 1. The SLT elaborated by these organisms is responsible for the endothelial damage that is the initial insult in the pathogenesis of the acute renal failure ...
W L, Robson, A K, Leung, B S, Kaplan
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HUS is one of the most common causes of acute renal failure in childhood. D+ HUS is the most common form and usually follows an episode of hemorrhagic colitis due to VTEC or S. dysenteriae type 1. The SLT elaborated by these organisms is responsible for the endothelial damage that is the initial insult in the pathogenesis of the acute renal failure ...
W L, Robson, A K, Leung, B S, Kaplan
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The Indian Journal of Pediatrics, 1987
Hemolytic uremic syndrome is primarily a disease of childhood. Seventy three children presented with clinical signs and symptoms were studied in detail. Seventy four percent of them were under two years of age. Many of these children had clinical evidence of involvement of organs other than the kidney. Mortality among the children studied was 60%.
B R, Nammalwar +3 more
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Hemolytic uremic syndrome is primarily a disease of childhood. Seventy three children presented with clinical signs and symptoms were studied in detail. Seventy four percent of them were under two years of age. Many of these children had clinical evidence of involvement of organs other than the kidney. Mortality among the children studied was 60%.
B R, Nammalwar +3 more
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Pediatric Clinics of North America, 1976
It is becoming increasingly apparent that the hemolytic uremic syndrome is a heterogenic and heterogeneous syndrome. There has been a dramatic reduction in the number of patients who die in the acute phase of the illness. Any claims for the use of heparin and streptokinase must be measured against the improved results which are now being obtained with ...
B S, Kaplan +2 more
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It is becoming increasingly apparent that the hemolytic uremic syndrome is a heterogenic and heterogeneous syndrome. There has been a dramatic reduction in the number of patients who die in the acute phase of the illness. Any claims for the use of heparin and streptokinase must be measured against the improved results which are now being obtained with ...
B S, Kaplan +2 more
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Nephron, 1973
The clinical and pathological characteristics of the acute stage of the HUS are described on the basis of 678 patients and the study of 52 autopsies and 3 kidney biopsies.
C A, Gianantonio +4 more
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The clinical and pathological characteristics of the acute stage of the HUS are described on the basis of 678 patients and the study of 52 autopsies and 3 kidney biopsies.
C A, Gianantonio +4 more
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Postgraduate Medicine, 1965
It is suggested that the hemolytic uremic syndrome is common to a number of morbid conditions and is not a new entity. Three illustrative cases are presented, all of them fatal. Necropsy revealed diverse pathologic processes (microangiopathic hemolytic anemia, acute glomerulonephritis with pyelonephritis, malignant hypertension).
S, SUSSMAN, S, FRENCH
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It is suggested that the hemolytic uremic syndrome is common to a number of morbid conditions and is not a new entity. Three illustrative cases are presented, all of them fatal. Necropsy revealed diverse pathologic processes (microangiopathic hemolytic anemia, acute glomerulonephritis with pyelonephritis, malignant hypertension).
S, SUSSMAN, S, FRENCH
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Atypical Hemolytic–Uremic Syndrome
New England Journal of Medicine, 2009The hemolytic–uremic syndrome, which is characterized by nonimmune hemolytic anemia, thrombocytopenia, and renal impairment, occurs most frequently in young children. Most cases are secondary to infection with Escherichia coli O157:H7 and other Shiga-toxin–producing strains.
Marina Noris, Giuseppe Remuzzi
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The Indian Journal of Pediatrics, 1984
There have been major advances in the understanding of pathogenesis and management of hemolytic uremic syndrome in the last decade. Since the consensus paper published in 2009 by the European Pediatric Study Group in 2009, there have been four prospective trials and multiple case reports on effective terminal blockade with Eculizumab, an international ...
A K, Shah, K R, Sheth
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There have been major advances in the understanding of pathogenesis and management of hemolytic uremic syndrome in the last decade. Since the consensus paper published in 2009 by the European Pediatric Study Group in 2009, there have been four prospective trials and multiple case reports on effective terminal blockade with Eculizumab, an international ...
A K, Shah, K R, Sheth
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Pediatrics in Review, 2020
1. Bernarda Viteri, MD* 2. Jeffrey M. Saland, MD† 1. *Children’s Hospital of Philadelphia, Philadelphia, PA 2. †Mount Sinai Kravis Children’s Hospital, New York, NY Thrombotic microangiopathy (TMA) was described by Moschcowitz in 1924, and the term hemolytic uremic syndrome (HUS) appeared by 1955 to describe a series of patients with small ...
Bernarda, Viteri, Jeffrey M, Saland
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1. Bernarda Viteri, MD* 2. Jeffrey M. Saland, MD† 1. *Children’s Hospital of Philadelphia, Philadelphia, PA 2. †Mount Sinai Kravis Children’s Hospital, New York, NY Thrombotic microangiopathy (TMA) was described by Moschcowitz in 1924, and the term hemolytic uremic syndrome (HUS) appeared by 1955 to describe a series of patients with small ...
Bernarda, Viteri, Jeffrey M, Saland
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The hemolytic uremic syndromes
Current Opinion in Critical Care, 2005Recent studies have provided a better understanding of the molecular mechanisms responsible for hemolytic uremic syndromes. In this review, we summarize biochemical and genetic data that may lead to new clinical approaches.The structures and modes of action of Shiga toxins have been deciphered.
Jessica, Caprioli +2 more
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