Results 51 to 60 of about 13,346 (189)

Clinical presentation of hemophagocytic lymphohistiocytosis in adults is less typical than in children

Clinics, 2016
OBJECTIVE: Hemophagocytic lymphohistiocytosis in adults is largely underdiagnosed. To improve the rate and accuracy of diagnosis in adults, the clinical and laboratory characteristics of hemophagocytic lymphohistiocytosis were analyzed in and compared ...
Zuojuan Zhang, Juandong Wang, Buqiang Ji, Tatiana von Bahr Greenwood, Yuan Zhang, Yongjing Wang, Dexiao Kong, Ai Li, Yang Jiang, Yanan Guo, Xiaoli Liu, Yingxue Wang, Aixia Dou, Nailin Li, Jan-Inge Henter, Guizhen Sun, Chengyun Zheng   +16 more
doaj   +1 more source

Acute hepatitis A infection‐associated hemophagocytic lymphohistiocytosis in adult presenting as impending acute liver failure: A case report and literature review

Clinical Case Reports, 2022
Hemophagocytic lymphohistiocytosis has been reported as a severe complication of various viral infections but unusual for the hepatitis A virus. We report a case of 25‐year‐old man with hepatitis A infection‐associated hemophagocytic lymphohistiocytosis ...
Panotpol Termsinsuk, Piyaporn Sirisanthiti   +1 more
doaj   +1 more source

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Hemophagocytic lymphohistiocytosis and visceral leishmaniasis in children: case report and systematic review of literature

Journal of Infection in Developing Countries, 2016
Hemophagocytic lymphohistiocytosis is a potentially fatal disorder resulting from excessive activation and non-malignant proliferation of T lymphocytes and macrophages.
Maria Scalzone, Antonio Ruggiero, Stefano Mastrangelo, Giovanna Trombatore, Vita Ridola, Palma Maurizi, Riccardo Riccardi   +6 more
doaj   +1 more source

A prediction model for acute kidney injury in adult patients with hemophagocytic lymphohistiocytosis

Frontiers in Immunology, 2022
Background and aimsHemophagocytic lymphohistiocytosis is a clinical syndrome resulting from abnormally active immune cells and a cytokine storm, with the accompanying phagocytosis of blood cells.
Siwen Wang, Siwen Wang, Lichuan Yang, Jiaojiao Zhou, Jia Yang, Xin Wang, Xuelian Chen, Ling Ji   +7 more
doaj   +1 more source

Ruxolitinib Pharmacokinetics and Exposure–Toxicity Relationship in Hematologic Malignancies and Immune‐Mediated Diseases: A Prospective Observational Study

Clinical Pharmacology &Therapeutics, EarlyView.
Ruxolitinib pharmacokinetics (PK) has been characterized in clinical trials but remains poorly documented in real‐world practice. This project aimed to investigate ruxolitinib PK in routine clinical practice, identify factors driving its variability, and explore exposure–response relationships to assess the potential role of therapeutic drug monitoring.
Jérémie Tachet, Sara C. Meyer, Francesco Grandoni, Emmanuel Haefliger, Monika Nagy‐Hulliger, Jörg P. Halter, Jakob R. Passweg, David Haefliger, Carine Bardinet, Laurent A. Decosterd, Monia Guidi, François R. Girardin   +11 more
wiley   +1 more source

Severe dengue, aneurysmal sub-arachnoid hemorrhage, and hemophagocytic lymphohistiocytosis: a rare case combination [PDF]

Einstein (São Paulo)
Dengue, a vector-borne acute febrile illness caused by members of the Flavivirus genus, has dramatically increased its occurrence worldwide. Neurological complications of dengue range from 2.63 to 40%, and subarachnoid hemorrhage is a rare, but ...
Saboor Mateen, Ajay Mishra, Shivesh Singh, Firdaus Jabeen   +3 more
doaj   +1 more source

Falciparum malaria-induced secondary hemophagocytic lymphohistiocytosis successfully treated with ruxolitinib

International Journal of Infectious Diseases, 2020
JAK/STAT signaling plays a major role in the pathogenesis of secondary hemophagocytic lymphohistiocytosis. This case report on a critically ill patient with secondary hemophagocytic lymphohistiocytosis due to falciparum malaria treated successfully with ...
André Fuchs, Hans-Martin Orth, Ulrich Germing, Mustafa Kondakci, Martha Holtfreter, Torsten Feldt, Björn Erik-Ole Jensen, Dieter Häussinger   +7 more
doaj   +1 more source

Hemophagocytic lymphohistiocytosis secondary to disseminated histoplasmosis, cytomegalovirus viremia, and nontuberculous mycobacteria bacteremia in a patient with recently diagnosed AIDS

IDCases, 2022
A 30-year-old Honduran male with recently diagnosed AIDS presented with a 1-month history of worsening abdominal pain, diarrhea, and fever. Initial investigations were notable for Cytomegalovirus viremia and diffuse lymphadenopathy.
Benjamin Fogelson, Krupa Patel, Jared Spoons, Shawna Stephens, Megan Edwards   +4 more
doaj   +1 more source

Successfully performed video capsule endoscopy in an 8‐month‐old infant weighing 7.5 kg

JPGN Reports, EarlyView.
Abstract Video capsule endoscopy (VCE) is a well‐established diagnostic tool for examining the small bowel. Limited data exist on its use in infants. To our knowledge, we present the first detailed case of a successful PillCam®SB3‐VCE performed in an 8‐month‐old infant weighing 7.5 kg with suspected small bowel bleeding following allogeneic ...
Paul‐Christoph Zeisler, Robert Thimme, Ulrike Teufel‐Schaefer, Michael Schultheiß   +3 more
wiley   +1 more source