Results 51 to 60 of about 36,076 (253)

Targeted high-throughput sequencing for genetic diagnostics of hemophagocytic lymphohistiocytosis [PDF]

, 2015
Background: Hemophagocytic lymphohistiocytosis (HLH) is a rapid-onset, potentially fatal hyperinflammatory syndrome. A prompt molecular diagnosis is crucial for appropriate clinical management.
Abboud, Miguel, Akar, Himmet Haluk, Belen, Burcu, Ben Bdira, Eya, Bryceson, Yenan T., Chiang, Samuel C. C., Devecioglu, Omer, Erichsen, Hans Christian, Fadoo, Zehra, Henter, Jan-Inge, Hästbacka, Johanna, Kaya, Zuhre, Lagerstedt-Robinson, Kristina, Meeths, Marie, Mottonen, Merja, Nordenskjold, Magnus, Nunes, Susana, Patiroglu, Turkan, Sabel, Magnus, Saribeyoglu, Ebru Tugrul, Tesi, Bianca, Tvedt, Tor Henrik, Unal, Ekrem, Unal, Sule, Unuvar, Aysegul, Yeoh, Allen E. J.   +25 more
core   +3 more sources

A Review of Hemophagocytic Lymphohistiocytosis in Patients Living with Human Immunodeficiency Virus

Open Forum Infectious Diseases, 2022
We provide an elaborate review of cases published between January 2005 and April 2021 on hemophagocytic lymphohistiocytosis (HLH) in HIV patients. Seventy articles describing 81 adult patients (age ≥19 years) were included. Median age was 40 years, and
Hussam Tabaja, A. Kanj, S. El Zein, I. Comba, O. Chehab, M. Mahmood   +5 more
semanticscholar   +1 more source

Babesia microti infection and hemophagocytic lymphohistiocytosis in an immunocompetent patient

International Journal of Infectious Diseases, 2017
Babesiosis is a rare and potentially severe tick-borne illness endemic to the Northeastern and upper Midwestern regions of the USA. Hemophagocytic lymphohistiocytosis is an uncommon condition resulting from over-activation of the immune system. The first
Shanette A. Go, Vania H. Phuoc, Sarah E. Eichenberg, Zelalem Temesgen, Thomas J. Beckman   +4 more
doaj   +1 more source

Successful use of emapalumab in refractory hemophagocytic lymphohistiocytosis in a child with Chédiak–Higashi syndrome: a case report

Journal of Medical Case Reports, 2023
Background Hemophagocytic lymphohistiocytosis is a life-threatening disease heralded by fever, cytopenia, hepatosplenomegaly, and multisystem organ failure.
Ali AlAhmari, Haitham Khogeer
doaj   +1 more source

Anakinra for the Treatment of Hemophagocytic Lymphohistiocytosis: 21 Cases

Journal of Clinical Medicine, 2022
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening cytokine storm syndrome. There are no definitive guidelines for the management of secondary HLH (sHLH).
C. Baverez, M. Grall, M. Gerfaud-Valentin, Sarah De Gail, A. Belot, T. Perpoint, E. Weber, Q. Reynaud, P. Sève, Y. Jamilloux   +9 more
semanticscholar   +1 more source

Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case report

Journal of Medical Case Reports, 2008
Introduction Hemophagocytic lymphohistiocytosis is an immune-mediated syndrome that typically has a rapidly progressive course that can result in pancytopenia, coagulopathy, multi-system organ failure and death.
Chan Kathryn, Behling Eric, Strayer David S, Kocher William S, Dessain Scott K   +4 more
doaj   +1 more source

Hemophagocytic Lymphohistiocytosis Gene Variants in Multisystem Inflammatory Syndrome in Children

Biology, 2022
Simple Summary Children with a COVID-19 infection are at risk of developing a novel syndrome called multisystem inflammatory syndrome in children (MIS-C). This disease state is characterized by a high level of inflammation.
A. Vagrecha, Mingce Zhang, S. Acharya, S. Lozinsky, Aaron Singer, Chana Levine, Maha Al-Ghafry, Carolyn Fein Levy, R. Cron   +8 more
semanticscholar   +1 more source

Mutations affecting mRNA splicing are the most common molecular defect in patients with familial hemophagocytic lymphohistiocytosis type 3

Haematologica, 2008
Mutations of UNC13D have been described in patients affected by familial hemophagocytic lymphohistiocytosis (FHL3). The Munc13-4 protein contributes to the priming of the secretory granules.
Alessandra Santoro, Sonia Cannella, Antonino Trizzino, Giuseppa Bruno, Carmen De Fusco, Luigi D. Notarangelo, Daniela Pende, Gillian M. Griffiths, Maurizio Aricò   +8 more
doaj   +1 more source

Hemophagocytic lymphohistiocytosis

Hematology/Oncology and Stem Cell Therapy, 2009
Hematol Oncol Stem Cell Ther 2(2) Second Quarter 2009 hemoncstem.edmgr.com 367 Hemophagocytic lymphohistiocytosis (HLH) is an unusual and rare syndrome characterized by fever, splenomegaly, pancytopenia, and the pathologic finding of hemophagocytosis (phagocytosis by macrophages of erythrocytes, leukocytes, platelets, and their precursors) in bone ...
Mitra, Bhaskar, Shrivastav, Ankit, Mukherjee, Krishnendu, Ghosh, Asit   +3 more
openaire   +3 more sources

The syndrome of hemophagocytic lymphohistiocytosis in primary immunodeficiencies: implications for differential diagnosis and pathogenesis

Haematologica, 2015
Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome defined by clinical and laboratory criteria. Current criteria were created to identify patients with familial hemophagocytic lmyphohistiocytosis in immediate need of immunosuppressive ...
Sebastian FN Bode, Sandra Ammann, Waleed Al-Herz, Mihaela Bataneant, Christopher C Dvorak, Stephan Gehring, Andrew Gennery, Kimberly C Gilmour, Luis I Gonzalez-Granado, Ute Groß-Wieltsch, Marianne Ifversen, Jenny Lingman-Framme, Susanne Matthes-Martin, Rolf Mesters, Isabelle Meyts, Joris M van Montfrans, Jana Pachlopnik Schmid, Sung-Yun Pai, Pere Soler-Palacin, Uta Schuermann, Volker Schuster, Markus G. Seidel, Carsten Speckmann, Polina Stepensky, Karl-Walter Sykora, Bianca Tesi, Thomas Vraetz, Catherine Waruiru, Yenan T. Bryceson, Despina Moshous, Kai Lehmberg, Michael B Jordan, Stephan Ehl   +32 more
doaj   +1 more source