Results 31 to 40 of about 36,076 (253)

Two cases of lung cancer with hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors

Thoracic Cancer, 2021
We report the cases of two patients with secondary hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors, who were diagnosed using the recently developed HScore.
Atsumasa Kurozumi, Hidenori Takahashi, Takayasu Watanabe, Yoshinobu Iwasaki   +3 more
doaj   +1 more source

Neutralization of IFN-γ reverts clinical and laboratory features in a mouse model of macrophage activation syndrome. [PDF]

, 2018
BACKGROUND: The pathogenesis of macrophage activation syndrome (MAS) is not clearly understood: a large body of evidence supports the involvement of mechanisms similar to those implicated in the setting of primary hemophagocytic lymphohistiocytosis ...
Bracaglia, Claudia, Caiello, Ivan, Chatel, Laurence, De Min, Cristina, Fabrizio De Benedetti, And, Ferlin, Walter G., Grom, Alexei A., Marasco, Emiliano, Pascarella, Antonia, Prencipe, Giusi, Strippoli, Raffaele   +10 more
core   +1 more source

Use of the JAK Inhibitor Ruxolitinib in the Treatment of Hemophagocytic Lymphohistiocytosis

Frontiers in Immunology, 2021
Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome driven by overactive T cells and macrophages that abundantly secrete numerous pro-inflammatory cytokines, including interferon (IFN)-gamma, interleukin (IL)-1-beta, IL-2, IL-6,
Camille Keenan, K. Nichols, Sabrin H Albeituni   +2 more
semanticscholar   +1 more source

An improved index for diagnosis and mortality prediction in malignancy associated hemophagocytic lymphohistiocytosis.

Blood, 2021
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening inflammatory syndrome that may complicate hematologic malignancies (HM). The appropriateness of current criteria for diagnosing HLH in the context of HMs is unknown because they were ...
A. Zoref-Lorenz, J. Murakami, L. Hofstetter, S. Iyer, Ahmad S. Alotaibi, S. Mohamed, P. Miller, Elad Guber, S. Weinstein, J. Yacobovich, S. Nikiforow, B. Ebert, A. Lane, O. Pasvolsky, P. Raanani, A. Nagler, N. Berliner, N. Daver, M. Ellis, M. Jordan   +19 more
semanticscholar   +1 more source

Hemophagocytic syndrome in patients with acute myeloid leukemia undergoing intensive chemotherapy

Haematologica, 2014
Hemophagocytic lymphohistiocytosis is a condition of immune dysregulation characterized by severe organ damage induced by a hyperinflammatory response and uncontrolled T-cell and macrophage activation.
Karen Delavigne, Emilie Bérard, Sarah Bertoli, Jill Corre, Eliane Duchayne, Cécile Demur, Véronique Mansat-De Mas, Cécile Borel, Muriel Picard, Muriel Alvarez, Audrey Sarry, Françoise Huguet, Christian Récher   +12 more
doaj   +1 more source

Screening of hemophagocytic lymphohistiocytosis in children with severe sepsis in pediatric intensive care

Science Progress, 2021
Background: We sought to screen for clinical and laboratory features of hemophagocytic lymphohistiocytosis among pediatric patients with severe sepsis.
Zeinab A El-Sayed, Rasha H El-Owaidy, Mohammed A Khamis, Ahmed R Rezk   +3 more
doaj   +1 more source

Cytophagic Histiocytic Panniculitis (CHP) in a Patient with SLE Found after Autopsy: When a Rash Is "Complicated!" [PDF]

, 2019
Introduction: Cytophagic histolytic panniculitis (CHP) is a clinical disorder characterized by nodular panniculitis of the subcutaneous adipose tissue. It was first described in 1980 by Winkelmann.
Abbas, Hafsa, Aslam, Ahsan, Chilimuri, Sridhar, Niazi, Masooma, Saad, Muhammad   +4 more
core   +1 more source

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition [PDF]

, 2016
Perforin, a pore-forming toxin released from secretory granules of NK cells and CTLs, is essential for their cytotoxic activity against infected or cancerous target cells.
Chaudhry, MS, Gilmour, KC, House, IG, Layton, M, Panoskaltsis, N, Sohal, M, Trapani, JA, Voskoboinik, I   +7 more
core   +1 more source

Hemophagocytic lymphohistiocytosis‐like toxicity (carHLH) after CD19‐specific CAR T‐cell therapy

British Journal of Haematology, 2021
Chimeric antigen receptor T‐cell (CAR T‐cell) therapy is associated with significant toxicities secondary to immune activation, including a rare but increasingly recognised severe toxicity resembling haemophagocytic lymphohistiocytosis (carHLH).
M. Hines, Camille Keenan, Gabriela M. Marón Alfaro, Cheng Cheng, Yinmei Zhou, Akshay Sharma, Caitlin Hurley, K. Nichols, S. Gottschalk, B. Triplett, Aimee C. Talleur   +10 more
semanticscholar   +1 more source

Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy. [PDF]

, 2016
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver ...
Decker, Kerry A, Fix, Oren K, Giard, Jeanne-Marie, Gill, Ryan M, Lai, Jennifer C, Logan, Aaron C   +5 more
core   +1 more source