Results 11 to 20 of about 36,076 (253)

Emapalumab in Children with Primary Hemophagocytic Lymphohistiocytosis.

New England Journal of Medicine, 2020
BACKGROUND Primary hemophagocytic lymphohistiocytosis is a rare syndrome characterized by immune dysregulation and hyperinflammation. It typically manifests in infancy and is associated with high mortality.
F. Locatelli, M. Jordan, C. Allen, S. Cesaro, C. Rizzari, A. Rao, B. Degar, T. Garrington, J. Sevilla, M. Putti, F. Fagioli, M. Ahlmann, J. Dapena Diaz, Michael M. Henry, F. De Benedetti, A. Grom, G. Lapeyre, P. Jacqmin, M. Ballabio, C. de Min   +19 more
semanticscholar   +3 more sources

Challenges in the diagnosis of hemophagocytic lymphohistiocytosis: Recommendations from the North American Consortium for Histiocytosis (NACHO)

Pediatric Blood and Cancer, 2019
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation, often associated with genetic defects of lymphocyte cytotoxicity.
M. Jordan, C. Allen, Jay Greenberg, Michael M. Henry, M. Hermiston, Ashish R. Kumar, M. Hines, O. Eckstein, S. Ladisch, K. Nichols, C. Rodríguez-Galindo, B. Wistinghausen, K. McClain   +12 more
semanticscholar   +3 more sources

Neurological symptoms of familial hemophagocytic lymphohistiocytosis type 2 [PDF]

Journal of Integrative Neuroscience, 2020
Hemophagocytic lymphohistiocytosis with central nervous system involvement is caused by inflammatory factor storms. The inflammatory factors invade the blood-brain barrier and further infiltrate brain tissue resulting in associated neurological and/or ...
Jingshi Wang, Houzhen Tuo, Lin Wu, Xinkai Wang, Zhao Wang
doaj   +1 more source

Immune Effector Cell associated Hemophagocytic Lymphohistiocytosis-like Syndrome (IEC-HS).

Transplantation and Cellular Therapy, 2023
BACKGROUND T cell mediated hyperinflammatory responses such as cytokine release syndrome (CRS) and immune effector cell associated neurotoxicity syndrome (ICANS) are now well-established toxicities of chimeric antigen receptor (CAR) T cells. As the field
M. Hines, Tristan E. Knight, K. McNerney, M. Leick, T. Jain, Saira S. Ahmed, M. Frigault, Joshua A. Hill, M. Jain, W. Johnson, Yi-Chung Lin, K. Mahadeo, Gabriela M. Maron, R. Marsh, S. Neelapu, S. Nikiforow, A. Ombrello, N. Shah, Aimee C. Talleur, David P Turicek, A. Vatsayan, S. Wong, M. Maus, K. Komanduri, N. Berliner, J. Henter, M. Perales, N. Frey, D. Teachey, M. Frank, N. Shah   +30 more
semanticscholar   +1 more source

Hemophagocytic lymphohistiocytosis during pregnancy: a review of the literature in epidemiology, pathogenesis, diagnosis and treatment

Orphanet Journal of Rare Diseases, 2021
Hemophagocytic lymphohistiocytosis during pregnancy is rare; it is often misdiagnosed, resulting in a high maternal and foetal mortality rate. Herein, based on limited case reports including antepartum and postpartum cases, we reviewed the current ...
Lidong Liu, Yutong Cui, Qiongjie Zhou, Huanqiang Zhao, Xiaotian Li   +4 more
doaj   +1 more source

An analysis of reported cases of hemophagocytic lymphohistiocytosis (HLH) after COVID-19 vaccination

Human Vaccines & Immunotherapeutics, 2023
Although COVID-19 vaccines are an effective public health tool to combat the global pandemic, serious adverse events, such as hemophagocytic lymphohistiocytosis (HLH), caused by them are a concern.
Hanqi Zhang, Buzi Cao, Q. Cao, Marady Hun, Lin Cao, Mingyi Zhao   +5 more
semanticscholar   +1 more source

Hemophagocytic Lymphohistiocytosis [PDF]

Indian Journal of Hematology and Blood Transfusion, 2012
Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder characterized by uncontrolled inflammation due to defective immune response. It may be familial or acquired, but both share a common feature of threatening the life of a patient and may lead to death unless treated by appropriate treatment. Here in we report a case of adult HLH.
A M V R, Narendra, G, Varun Kumar, A, Krishna Prasad, M, Shetty, Megha S, Uppin, V R, Srinivasan   +5 more
openaire   +2 more sources

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Macrophage Activation Syndrome as Onset of Systemic Lupus Erythematosus: A Case Report and a Review of the Literature [PDF]

, 2015
Macrophage activation syndrome (MAS) is a potentially fatal condition. It is a rare complication of several autoimmune disorders, including systemic lupus erythematosus (SLE) and systemic juvenile idiopathic arthritis (sJIA).
Didona, Dario, Feola, Aldo, Granata, Guido, Granata, Massimo, Stifano, Giuseppina   +4 more
core   +7 more sources

Tuberculosis-Associated Hemophagocytic Lymphohistiocytosis: A Review of Current Literature

Journal of Clinical Medicine, 2023
Hemophagocytic lymphohistiocytosis (HLH) is a condition of immune dysregulation and hyperinflammation, leading to organ failure and death. Malignancy, autoimmune conditions, and infections, including Mycobacterium tuberculosis (TB), are all considered ...
Trym Fauchald, B. Blomberg, H. Reikvam
semanticscholar   +1 more source