Results 21 to 30 of about 36,076 (253)
Diagnosis and Management of Adult Malignancy-Associated Hemophagocytic Lymphohistiocytosis
Cancers, 2023 Simple Summary Although rare, hemophagocytic lymphohistiocytosis (HLH), a syndrome of severe, dysregulated inflammation, is associated with poor survival when it occurs in conjunction with malignancy.
Jerry C Lee, A. Logan
semanticscholar +1 more source
Ruxolitinib-based regimen in children with primary hemophagocytic lymphohistiocytosis
Haematologica, 2023 Primary hemophagocytic lymphohistiocytosis (pHLH) is a rare immune disorder and hematopoietic stem cell transplantation (HSCT) is the only potentially curative treatment.
J. Ge +14 more
semanticscholar +1 more source
Blood, 2022 Hemophagocytic lymphohistiocytosis (HLH) is a lethal disorder characterized by hyperinflammation. Recently, ruxolitinib, targeting key cytokines in HLH, has shown promise for HLH treatment.
Qing Zhang +10 more
semanticscholar +1 more source
Serum cytokine pattern in children with hemophagocytic lymphohistiocytosis
Annals of Hematology, 2023 This study aimed to compare the serum levels of 34 cytokines of children with hemophagocytic lymphohistiocytosis (HLH) and explored the specific cytokine pattern of HLH subtypes and the relationship between cytokine levels and prognosis.
W. Ou +10 more
semanticscholar +1 more source
Critical Care Explorations, 2021 Objectives:. Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory disorder that is associated with high morbidity and mortality in the ICU. It has also been associated with acute liver failure. Design:.
Nawar Al Nasrallah, MD +3 more
doaj +1 more source
Secondary hemophagocytic lymphohistiocytosis in children (Review)
Experimental and Therapeutic Medicine, 2023 Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening condition characterized by hyperinflammation in an uncontrolled and ineffective immune response. Despite great improvement in diagnosis and treatment, it still represents a challenge in
C. Benevenuta +3 more
semanticscholar +1 more source
Familial hemophagocytic lymphohistiocytosis [PDF]
Indian Journal of Hematology and Blood Transfusion, 2009 A 45-day-old infant presented with hepatosplenomegaly and fever since 15 days. Hemogram revealed bicytopenia and bone marrow aspirate showed hemophagocytosis. With the history of death of two siblings, the baby was diagnosed with hemophagocytic lymphohistiocytosis (HLH), likely to be of familial origin.
S, Raka +3 more
openaire +2 more sources
Blood, 2023 Key Points • The annual incidence of malignancy-associated HLH is ≥0.62 per 100 000 adults, and it affects ≥0.6% of all hematological malignancies.• Increased incidence and short-term survival are likely due to increased awareness of HLH and earlier and ...
Alexandra Löfstedt +3 more
semanticscholar +1 more source
A hemophagocytic lymphohistiocytosis case with newly defined UNC13D (C.175G>C; p.Ala59Pro) mutation and a rare complication [PDF]
, 2015 Hemophagocytic lymphohistiocytosis (HLH) represents a severe hyperinflammatory condition with cardinal symptoms of prolonged fever, cytopenias, hepatosplenomegaly, and hemophagocytosis by activated, morphologically benign macrophages with impaired ...
Akpınar, Funda Özgürler +7 more
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Haematologica, 2015 The hyperinflammatory syndrome hemophagocytic lymphohistiocytosis can occur in the context of malignancies. Malignancy-triggered hemophagocytic lymphohistiocytosis should be regarded seperately from hemophagocytic lymphohistiocytosis during ...
Kai Lehmberg +9 more
doaj +1 more source