Results 21 to 30 of about 21,085 (234)

Neurological symptoms of familial hemophagocytic lymphohistiocytosis type 2 [PDF]

Journal of Integrative Neuroscience, 2020
Hemophagocytic lymphohistiocytosis with central nervous system involvement is caused by inflammatory factor storms. The inflammatory factors invade the blood-brain barrier and further infiltrate brain tissue resulting in associated neurological and/or ...
Jingshi Wang, Houzhen Tuo, Lin Wu, Xinkai Wang, Zhao Wang
doaj   +1 more source

Hemophagocytic lymphohistiocytosis during pregnancy: a review of the literature in epidemiology, pathogenesis, diagnosis and treatment

Orphanet Journal of Rare Diseases, 2021
Hemophagocytic lymphohistiocytosis during pregnancy is rare; it is often misdiagnosed, resulting in a high maternal and foetal mortality rate. Herein, based on limited case reports including antepartum and postpartum cases, we reviewed the current ...
Lidong Liu, Yutong Cui, Qiongjie Zhou, Huanqiang Zhao, Xiaotian Li   +4 more
doaj   +1 more source

[Hemophagocytic lymphohistiocytosis]. [PDF]

Nihon rinsho. Japanese journal of clinical medicine, 2013
Hemophagocytic lymphohistiocytosis (HLH) is a frequently fatal and likely underdiagnosed disease involving a final common pathway of hypercytokinemia, which can result in end-organ damage and death. Although an early diagnosis is crucial to decrease mortality, the definitive diagnosis is often challenging because of the lack of specificity of currently
Flavia G N, Rosado, Annette S, Kim
openaire   +5 more sources

Hemophagocytic Lymphohistiocytosis [PDF]

Indian Journal of Hematology and Blood Transfusion, 2012
Hemophagocytic lymphohistiocytosis (HLH) is an immune disorder characterized by uncontrolled inflammation due to defective immune response. It may be familial or acquired, but both share a common feature of threatening the life of a patient and may lead to death unless treated by appropriate treatment. Here in we report a case of adult HLH.
A M V R, Narendra, G, Varun Kumar, A, Krishna Prasad, M, Shetty, Megha S, Uppin, V R, Srinivasan   +5 more
openaire   +2 more sources

Consensus-Based Guidelines for the Recognition, Diagnosis, and Management of Hemophagocytic Lymphohistiocytosis in Critically Ill Children and Adults [PDF]

, 2022
OBJECTIVE: Hemophagocytic lymphohistiocytosis is a hyperinflammatory syndrome that often requires critical care support and remains difficult to diagnose.
Janka, G., Lachmann, G., Paul La Rosée, Lehmberg, K., Shakoory, B., AnnaCarin Horne, Gritta Janka, Machowicz, R., La Rosée, P., Hines, M. R., Kai Lehmberg, Päivi Miettunen, Bita Shakoory, Jan-Inge Henter, Michael B. Jordan, Miettunen, P., Horne, A., Melissa R. Hines, Van Laar, J. A. M., Henter, J. I., Beutel, K., Jordan, M. B., Karin Beutel, Beutel, G., J. Allyson Hays, Tatiana von Bahr Greenwood, Jan A. M. van Laar, Hays, J. A., Gunnar Lachmann, Rafal Machowicz, Zinter, M. S., Matt S. Zinter, Gernot Beutel, Von Bahr Greenwood, T., Horne, AnnaCarin, Miettunen, Päivi, von Bahr Greenwood, Tatiana, Jordan, MB, Beutel, Gernot, Hays, J Allyson, Zinter, Matt S, Jordan, Michael B, Lehmberg, Kai, Shakoory, Bita, Beutel, K, van, Laar JAM, Beutel, G, van Laar, Jan A M, Hines, MR, Hines, Melissa R, Janka, G, Beutel, Karin, Janka, Gritta, Machowicz, Rafal, Horne, A,, Hays, JA, La Rosée, Paul, von, Bahr Greenwood T,, Lachmann, Gunnar, Lachmann, G, Henter, Jan-Inge   +60 more
core   +1 more source

Neonates with acute liver failure have higher overall mortality but similar posttransplant outcomes as older infants

Liver Transplantation, EarlyView., 2022
Abstract Neonatal acute liver failure (ALF) carries a high mortality rate; however, little data exist on its peritransplant hospital course. This project aimed to identify factors associated with outcomes in neonates with ALF using large multicenter databases.
Swati Antala, Bridget Whitehead, Justin Godown, Matt Hall, Anna Banc‐Husu, Estella M. Alonso, Sarah A. Taylor   +6 more
wiley   +1 more source

Dynamic early biomarkers predict outcomes in pediatric Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. [PDF]

Pediatr Investig
This study elucidates the critical pathogenic mechanisms of pediatric Epstein–Barr virus‐associated hemophagocytic lymphohistiocytosis (EBV‐HLH), where EBV infection triggers a cytokine storm leading to immune cell hyperactivation and tissue damage. Dynamic plasma biomarkers (EBV‐DNA, ferritin, and interferon‐γ) effectively predict treatment response ...
Liu F, Zhang Q, Chen S, Zhao Y, Wang D, Lian H, Ma H, Wang T, Zhang R, Li Z.   +9 more
europepmc   +2 more sources

Hemophagocytic Lymphohistiocytosis in the Medical ICU: A Single-Institution Cohort Study on Acute Liver Failure and Mortality

Critical Care Explorations, 2021
Objectives:. Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory disorder that is associated with high morbidity and mortality in the ICU. It has also been associated with acute liver failure. Design:.
Nawar Al Nasrallah, MD, Ahmad Al-Hader, MD, Niharika Samala, MBBS, Catherine R. Sears, MD, ATSF   +3 more
doaj   +1 more source

Approaching hemophagocytic lymphohistiocytosis

Frontiers in Immunology, 2023
Hemophagocytic Lymphohistiocytosis (HLH) is a rare clinical condition characterized by sustained but ineffective immune system activation, leading to severe and systemic hyperinflammation. It may occur as a genetic or sporadic condition, often triggered by an infection.
Aurora Chinnici, Aurora Chinnici, Linda Beneforti, Linda Beneforti, Francesco Pegoraro, Francesco Pegoraro, Irene Trambusti, Annalisa Tondo, Claudio Favre, Maria Luisa Coniglio, Elena Sieni   +10 more
openaire   +4 more sources

Two cases of lung cancer with hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors

Thoracic Cancer, 2021
We report the cases of two patients with secondary hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors, who were diagnosed using the recently developed HScore.
Atsumasa Kurozumi, Hidenori Takahashi, Takayasu Watanabe, Yoshinobu Iwasaki   +3 more
doaj   +1 more source