Results 111 to 120 of about 83,381 (315)

Maximum Likelihood Estimation of the Multivariate Normal Mixture Model [PDF]

The Hessian of the multivariate normal mixture model is derived, and estimators of the information matrix are obtained, thus enabling consistent estimation of all parameters and their precisions.
Boldea, Otilia, Magnus, Jan R.
core   +1 more source

Health‐Related Quality of Life, Physical Activity and Joint Health in People With Severe Haemophilia A Receiving Emicizumab: Results From the Phase IV HemiNorth 2 Study

Haemophilia, EarlyView.
ABSTRACT Introduction Despite factor (F)VIII prophylaxis, a perceived increased risk of bleeding for some people with severe haemophilia A (PwSHA) exists, limiting physical activity (PA) and restricting quality of life (QoL). Aim HemiNorth 2 (EudraCT# 2020‐003256‐32) is an interventional study evaluating the impact of switching from FVIII prophylaxis ...
Jan Astermark, Susanna Ranta, Linda Myrin‐Westesson, Marianne Hoffmann, Sandrine Quere, Amparo Yovanna Castro Sanchez, Susan Robson, Tünde Czirok, Riitta Lassila, Pål André Holme   +9 more
wiley   +1 more source

The Health-Related Quality of Life scores and joint health in children and young adults with hemophilia

The Turkish Journal of Pediatrics
Background. Patients with hemophilia should be evaluated for joint health and overall health in their visits. The aims of this study were to evaluate joint health and health-related quality of life (HRQoL) in patients with mild, moderate, and severe ...
Buse Günyel, Mesut Bulakçı, Gamze Başkent, Ayşegül Ünüvar   +3 more
doaj   +1 more source

Hemophilia B in a Pair of Monozygotic Negro Twins [PDF]

, 1964
Israel Roisenberg
openalex   +1 more source

Determining the Impact of Combination Oral Contraceptives on Von Willebrand Factor and Factor VIII in Healthy Patients and Patients With Von Willebrand Disease: A Scoping Review and Meta‐Analysis

Haemophilia, EarlyView.
ABSTRACT Introduction Von Willebrand disease (VWD) is a bleeding disorder characterized by a deficiency or dysfunction of Von Willebrand factor (VWF) and/or Factor VIII (FVIII), critical coagulation proteins. Individuals with VWD often use combination oral contraceptives (COCs) to manage heavy menstrual bleeding.
Eve Justason, Anna M. Ishchuk, Benjamin P. Ott, M. E. Sophie Gibson, Paula D. James   +4 more
wiley   +1 more source

Studies of the Metabolism and Distribution of Fibrinogen in Patients with Hemophilia A* [PDF]

, 1967
Y. Takeda, Alan Y. Chen
openalex   +1 more source

Prevalence and Impact of Heavy Menstrual Bleeding in Women With von Willebrand Disease Across Age Groups: A Retrospective Study

Haemophilia, EarlyView.
ABSTRACT Introduction Heavy menstrual bleeding (HMB) is a common and burdensome symptom in women with von Willebrand disease (VWD). Although VWD and HMB have been studied, the prevalence and impact of HMB across different age groups remains underexplored. Aim To investigate the prevalence and impact of HMB in women with VWD across different age groups.
Anna Olsson, Petra Elfvinge, Eva Zetterberg, Linda Myrin‐Westesson   +3 more
wiley   +1 more source

Historical Note: The Earliest Record of Hemophilia in America? [PDF]

, 1962
Victor A. McKusick
openalex   +1 more source

TREATMENT OF HEMOPHILIA WITH HUMAN FACTORIX PRODUCED IN MAMIMARY TISSUE OF TRANSGENIC MAMMALS [PDF]

, 2008
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention.
Drohan, William N., Johnson, John L., Johnson, Mary Ann H., Lubon, Henryk, Velander, William H.   +4 more
core   +1 more source

Management of von Willebrand Disease With a Factor VIII‐Poor von Willebrand Factor Concentrate: Results From the Paediatric Cohort of a Prospective Observational Post‐Marketing Study

Haemophilia, EarlyView.
ABSTRACT Introduction Although clinical experience of a triple‐secured, plasma‐derived, von Willebrand factor (pdVWF), almost devoid of Factor VIII (FVIII) in adults with von Willebrand disease (VWD), is widely reported, its use in children is less documented.
Jenny Goudemand, Annie Borel‐Derlon, Ségolène Claeyssens, Hervé Chambost, Guillaume Mourey, Annie Harroche, Sandrine Meunier, Céline Henriet, Thierry Leroi, Sophie Susen, Yohann Repesse   +10 more
wiley   +1 more source