Results 41 to 50 of about 32,279 (169)

Hemophilia is associated with accelerated biological aging

Haematologica
Hemophilia is a rare X-linked bleeding disorder caused by mutations in the F8 or F9 gene (hemophilia A or B), leading to deficient factor VIII or IX proteins, respectively.
Marina Trappl, Rafaela Vostatek, Manuel Salzmann, Daniel Kraemmer, Johanna Gebhart, Philipp Hohensinner, Ingrid Pabinger, Cihan Ay   +7 more
doaj   +1 more source

The Health-Related Quality of Life scores and joint health in children and young adults with hemophilia

The Turkish Journal of Pediatrics
Background. Patients with hemophilia should be evaluated for joint health and overall health in their visits. The aims of this study were to evaluate joint health and health-related quality of life (HRQoL) in patients with mild, moderate, and severe ...
Buse Günyel, Mesut Bulakçı, Gamze Başkent, Ayşegül Ünüvar   +3 more
doaj   +1 more source

POLYMORPHISM OF THROMBOPHILIA GENES AND THEIR ROLE IN DEVELOPMENT OF DIFFERENT DISEASE PHENOTYPES AND THROMBOTIC COMPLICATIONS IN HEMOPHILIA PATIENTS

Сибирский научный медицинский журнал, 2019
Objective was to study genetic markers of thrombophilia in patients with hemophilia, which can affect the course of the disease and contribute to thrombotic complications. Material and methods.
T. Yu. Polyanskaya, I. S. Fevraleva, E. E. Karpov, N. V. Sadykova, M. S. Sampiev, A. V. Golobokov, G. V. Mishin, D. Yu. Petrovskiy, A. A. Koroleva, G. M. Galstyan, A. B. Sudarikov, V. Yu. Zorenko   +11 more
doaj   +1 more source

Hemoaction game: an educational step to improve hemophilia children and nurses self-efficacy

Journal of Advances in Medical Education and Professionalism, 2016
As hemophilia is a chronic bleeding disease and can interfere with daily performance of children, these children require continuous training to prevent bleeding and take timely action (1).
NOOASHIN BEHESHTIPOOR, SHIRIN GHANAVATI, MITRA EDRAKI, MEHRAN KARIMI, SEZANEH HAGHPANAH   +4 more
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Acquired hemophilia A

Hematology, 2006
Acquired hemophilia A is a rare but severe autoimmune bleeding disorder, resulting from the presence of autoantibodies directed against clotting factor VIII. The etiology of the disorder remains obscure, although approximately half of all cases are associated with other underlying conditions.
openaire   +2 more sources

Why is the uptake of gene therapy in hemophilia less than expected?

Research and Practice in Thrombosis and Haemostasis
Gene therapy has held promise to cure hemophilia since factor (F)VIII and FIX were cloned more than 40 years ago. However, scientific understanding of the adeno-associated virus, the predominant vector used in gene therapy, has been insufficient to ...
Glenn F. Pierce, Mark Skinner, Brian O’Mahony, Dawn Rotellini, Radoslaw Kaczmarek   +4 more
doaj   +1 more source

Strengthening hemophilia registries globally: Strategies to improve patient outcomes

Iraqi Journal of Hematology
Hemophilia is a genetic bleeding disorder characterized by a deficiency of clotting factor VIII or IX. Hemophilia registries are structured databases that maintain longitudinal data on people diagnosed with hemophilia. Hemophilia registries maintained at
Saurabh RamBihariLal Shrivastava, Prateek Sudhakar Bobhate, Shweta Sonkusale, Neha Jaiswal   +3 more
doaj   +1 more source

Haemophilia B: an illustrative review of current challenges and opportunities

Research and Practice in Thrombosis and Haemostasis
Background: Hemophilia B is a genetic bleeding disorder caused by a deficiency of clotting factor IX, which presents unique challenges in clinical management.
Cedric Hermans, Jan Astermark, Sonata Šaulytė Trakymienė, Víctor Jiménez-Yuste   +3 more
doaj   +1 more source

Evidence-based dental management strategies for individuals with congenital hemophilia: a systematic review

BMC Oral Health
Background People with hemophilia commonly present with a range of bleeding symptoms, from minor oral cavity bleeds to life-threatening events such as intracranial hemorrhage.
Mathangi Kumar, Sulochana Badagabettu, Keerthilatha M Pai, Linu Sara George   +3 more
doaj   +1 more source

Patient and parent preferences for characteristics of prophylactic treatment in hemophilia

Patient Preference and Adherence, 2015
Roberto Furlan,1 Sangeeta Krishnan,2 Jeffrey Vietri3 1Advanced Methods, Kantar Health, Epsom, Surrey, UK; 2Global Health Economics and Outcomes Research, Biogen, MA, USA; 3Health Outcomes, Kantar Health, Milan, Italy Introduction: New longer-acting ...
Furlan R, Krishnan S, Vietri J
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