Results 111 to 120 of about 78,600 (311)
Historical Note: The Earliest Record of Hemophilia in America? [PDF]
, 1962 Victor A. McKusick
openalex +1 more source
Maximum Likelihood Estimation of the Multivariate Normal Mixture Model [PDF]
The Hessian of the multivariate normal mixture model is derived, and estimators of the information matrix are obtained, thus enabling consistent estimation of all parameters and their precisions.
Boldea, Otilia, Magnus, Jan R.
core +1 more source
The Mirage of Factor Equivalence: Examining the Complexities of Non‐Factor Therapies in Haemophilia
Haemophilia, EarlyView.ABSTRACT Background This article provides a critical analysis of the ‘factor equivalence’ concept as applied to non‐factor therapies (NFTs) for haemophilia, highlighting its limitations and clinical implications. Although factor equivalence estimates serve as a comparative tool for evaluating pro‐coagulant effects across different therapies, they may ...
Yesim Dargaud +2 more
wiley +1 more source
Studies of the Metabolism and Distribution of Fibrinogen in Patients with Hemophilia A* [PDF]
, 1967 Y. Takeda, Alan Y. Chen
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TREATMENT OF HEMOPHILIA WITH HUMAN FACTORIX PRODUCED IN MAMIMARY TISSUE OF TRANSGENIC MAMMALS [PDF]
, 2008 Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present invention.
Drohan, William N. +4 more
core +1 more source
PROTHROMBIN IN ENZYMOLOGY, THROMBOSIS AND HEMOPHILIA [PDF]
, 1968 G. I. C. Ingram
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ORAL TREATMENT OF HEMOPHILIA [PDF]
, 2007 Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome.
Alpan, Oral +3 more
core +1 more source
The UK Infected Blood Inquiry: A Personal Reflection
Haemophilia, EarlyView.
Peter R. Foster
wiley +1 more source
Haemophilia, EarlyView.ABSTRACT Introduction Haemophilia A and B are hereditary bleeding disorders that require multidisciplinary perioperative management. Data on orthopaedic surgery outcomes with extended‐half‐life (EHL) recombinant Fc‐fusion factor VIII (rFVIIIFc) and factor IX (rFIXFc) products remain limited.
Luigi Piero Solimeno +10 more
wiley +1 more source