Results 51 to 60 of about 2,583,576 (275)
Objective: Hemophilia A (HA) is the most severe X-linked inherited bleeding disorder caused by hemizygous mutations in the factor 8 (F8) gene. The aim of this study is to determine the mutation spectrum of the F8 gene in a large HA cohort from Turkey ...
Tahir Atik+22 more
doaj +1 more source
PRP or not PRP: Is the debate surrounding platelets‐based blood‐derived products evolving?
Abstract The increasing interest in biologic treatments for musculoskeletal disorders has led to the advancement of orthobiologics, particularly in non‐operative care through injectable therapies. However, defining these treatments clearly is crucial for proper clinical application.
Enrico Ragni+4 more
wiley +1 more source
Dynamical systems generated by a gonosomal evolution operator [PDF]
In this paper we consider discrete-time dynamical systems generated by gonosomal evolution operators of sex linked inheritance. Mainly we study dynamical systems of a hemophilia, which biologically is a group of hereditary genetic disorders that impair the body's ability to control blood clotting or coagulation, which is used to stop bleeding when a ...
arxiv
Conditions for the difference set of a central Cantor set to be a Cantorval. Part II [PDF]
Let C(a) be the central Cantor set generated by a sequence a with terms in (0,1). It is known that the difference set C(a)-C(a) of C(a) can has one of three possible forms: a finite union of closed intervals, a Cantor set, or a Cantorval. In the previous paper there was proved a sufficient condition for the sequence a which implies that C(a) - C(a) is ...
arxiv
Abstract Purpose Patello–femoral instability (PFI) is often caused by predisposing factors, with trochlea dysplasia (TD) as the most prominent. Untreated patellar instability leads to impaired function and an increased risk of patellofemoral osteoarthritis.
Christian Dippmann+4 more
wiley +1 more source
Spontaneous Retroperitoneal Hemorrhage Caused by Idiopathic Acquired Hemophilia A Misdiagnosed as a Delayed Traumatic Hematoma: A Case Report [PDF]
Acquired hemophilia A (AHA) is a rare disease where typically coagulation factor VIII is inhibited by autoantibodies. It occurs in patients with no personal or familial history of bleeding.
Seon Hee Kim+4 more
doaj +1 more source
Antithrombin: Deficiency, Diversity, and the Future of Diagnostics
ABSTRACT Our healthcare system provides reactive sick‐care, treating patients after symptoms have appeared by prescription of generic and often suboptimal therapy. This strategy brings along high costs and high pressure which is not sustainable.
Mirjam Kruijt+2 more
wiley +1 more source
The dynamics of gonosomal evolution operators [PDF]
In this paper we investigate the dynamical systems generated by gonosomal evolution operator of sex linked inheritance depending on parameters. Mainly we study dynamical systems of a hemophilia which is biological group of disorders connected with genes that diminish the body's ability to control blood clotting or coagulation that is used to stop ...
arxiv
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa+4 more
wiley +1 more source
Structure of the Fab fragment of a humanized 5E5 antibody to a cancer‐specific Tn‐MUC1 epitope
The structure of the humanized Fab from murine monoclonal antibody 5E5 specific for tumor antigen Tn‐MUC1 has been determined to 1.57 Å resolution. The humanization process has imposed changes in the framework regions of the Fv which may have affected the Vh–Vl interface.The structure of the humanized Fab from murine monoclonal antibody 5E5 specific ...
Wei Li+7 more
wiley +1 more source