Results 101 to 110 of about 301,643 (264)

Trends in Treatment of Severe Haemophilia and Impact on Inhibitor Assessment by the EUHASS Registry

open access: yesHaemophilia, EarlyView.
ABSTRACT Background The last 15 years have seen new extended half‐life (EHL) recombinant FVIII/IX concentrates and nonreplacement therapy for haemophilia A (emicizumab) introduced in Europe. These changes affect FVIII/IX exposure in previously untreated patients (PUPs) and previously treated patients (PTPs) with severe haemophilia A and B (SHA and SHB)
Kathelijn Fischer   +10 more
wiley   +1 more source

Advances of adeno-associated virus applied in gene therapy to hemophilia from bench work to the clinical use

open access: yesBlood Science, 2019
. Hemophilia A and B are diseases caused by a single gene deficiency and are thus suitable for gene therapy. In recent clinical research, adeno-associated virus (AAV) was employed by several teams in the treatment of hemophilia A and B, and the outcomes ...
Xiaolei Pei, Mingzhe Han, Lei Zhang
doaj   +1 more source

Comparison of Two Augmentation Methods in Improving Detection Accuracy of Hemarthrosis [PDF]

open access: yesarXiv
With the increase of computing power, machine learning models in medical imaging have been introduced to help in rending medical diagnosis and inspection, like hemophilia, a rare disorder in which blood cannot clot normally. Often, one of the bottlenecks of detecting hemophilia is the lack of data available to train the algorithm to increase the ...
arxiv  

Property (gw) for tensor product and left-right multiplication operators [PDF]

open access: yesActa Sci. Math. (Szeged) 78 (3-4) (2012), 589-607, 2014
Given Banach spaces $X$ and $Y$ and operators $A\in B(X)$ and $B\in B(Y)$, property $(gw)$ does not in general transfer from $A$ and $B$ to the tensor product operator $A\otimes B\in B(X\overline{\otimes} Y)$ or to the elementary operator defined by $A$ and $B$, $\tau_{AB}=L_AR_B\in B(B(Y,X))$.
arxiv  

The UK Infected Blood Inquiry: A Personal Reflection

open access: yesHaemophilia, EarlyView.
ABSTRACT The UK Infected Blood Inquiry (IBI) considered the transfusion transmitted infections hepatitis B and C, HIV, and vCJD. The inquiry lasted 6 years during 2018 to 2024 and reported to the UK parliament on 20 May, 2024. It concluded that at least 3000 people died because of the recklessness and obstinacy of officialdom and it has been reported ...
Christine A. Lee
wiley   +1 more source

Hemophilia B with inhibitor: molecular analysis of the subtotal deletion of the factor IX gene [PDF]

open access: bronze, 1985
H. J. Hassan   +8 more
openalex   +1 more source

Safety and Efficacy of a Novel Sealant‐Based Vascular Closure Device Following Electrophysiology Procedures: ReliaSeal Trial

open access: yesJournal of Cardiovascular Electrophysiology, EarlyView.
In a clinical trial of a novel sealant‐based VCD to achieve hemostasis following endovascular procedures, patients randomized to receive the MYNX CONTROL VENOUS VCD had decreased TTH, TTA, and TDE, as compared to patients who received MC. ABSTRACT Background While manual compression (MC) remains the standard of care to achieve hemostasis, a novel ...
John Summers   +15 more
wiley   +1 more source

Multicenter Study of Diagnostic Tool for Patients with Hemophilia: From Bedside to Comprehensive Investigations

open access: yesThe Application of Clinical Genetics, 2023
Ampaiwan Chuansumrit,1 Rungrote Natesirinilkul,2 Nongnuch Sirachainan,1 Praguywan Kadegasem,1 Pacharapan Surapolchai,3 Noppawan Tangbubpha,1 Ketsuda Kempka,1 Tanyanee Khlangtan1 1Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital ...
Chuansumrit A   +7 more
doaj  

A Bayesian Approach for Selecting Relevant External Data (BASE): Application to a study of Long-Term Outcomes in a Hemophilia Gene Therapy Trial [PDF]

open access: yesarXiv
Gene therapies aim to address the root causes of diseases, particularly those stemming from rare genetic defects that can be life-threatening or severely debilitating. Although an increasing number of gene therapies have received regulatory approvals in recent years, understanding their long-term efficacy in trials with limited follow-up time remains ...
arxiv  

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