Results 131 to 140 of about 49,324 (252)

INDUCTION OF TOLERANCE BY ORAL ADMINISTRATION OF FACTOR VIII AND TREATMENT OF HEMOPHILA [PDF]

, 2011
Disclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a Subject a therapeutically effective amount of the deficient anti gen, wherein the antigen is not present in a liposome.
Alpan, Oral, Kamala, Tirumalai, Matzinger, Polly, Velander, William Hugold   +3 more
core   +1 more source

Multivariable model integrating PHI and mpMRI for detecting csPCa in biopsy‐naïve men

BJUI Compass, Volume 6, Issue 12, December 2025.
Abstract Background The integration of blood‐based biomarkers and multiparametric magnetic resonance imaging (mpMRI) has been proposed to improve prostate cancer (PCa) diagnosis. However, few validated models combine both tools to support risk‐adapted clinical decision‐making.
Mario Dominguez Esteban, Ester Fernandez Guzman, Enrique Ramos Barselo, Ernesto Herrero Blanco, Sergio Zubillaga Guerrero, Roberto Ballestero Diego, Alejandro Fernandez Florez, Jose Javier Gomez Roman, Jaime Garcia Herrero, Marina Sanchez Gil, Guillermo Velilla Diez, Felix Campos Juanatey, Maria Teresa Garcia Unzueta, Jose Luis Gutierrez Baños   +13 more
wiley   +1 more source

Persistent Expression of hF.IX After Tolerance Induction by In Utero or Neonatal Administration of AAV-1-F.IX in Hemophilia B Mice [PDF]

, 2007
Denise E. Sabatino, Tippi C. MacKenzie, William H. Peranteau, Shyrie Edmonson, Cesare Campagnoli, Yilin Liu, Alan W. Flake, Katherine A. High   +7 more
openalex   +1 more source

Von Drygalski A, Giermasz A, Castaman G, et al. Etranacogene dezaparvovec (AMT-061 phase 2b): normal/near normal FIX activity and bleed cessation in hemophilia B. Blood Adv. 2019;3(21):3241-3247. [PDF]

, 2020

openalex   +1 more source

M/G‐Ratio‐Tuned Calcium Alginate Hydrogel Microcarrier for Controlled Delivery of Adeno‐Associated Virus for Gene Therapy

Biotechnology and Bioengineering, Volume 122, Issue 12, Page 3433-3445, December 2025.
ABSTRACT This paper proposes the controlled release of adeno‐associated virus (AAV) by polymer mesh structures of alginate hydrogel microbeads (gel‐beads). The polymer mesh structure of alginate hydrogel can be controlled by adjusting the number of cross‐linking points depending on the molecular structure (M/G ratio) of the alginate hydrogel.
Aiki Hioki, Shuhei Takatsuka, Yuta Kurashina, Hiroaki Onoe   +3 more
wiley   +1 more source

Clinical audit of inherited bleeding disorders in a developing country

Indian Journal of Pathology and Microbiology, 2010
Objective: We did a clinical audit to determine the status of coagulation disorders in a hemophilia care center in Pakistan. Setting: Fatimid foundation blood bank and hematological diseases center, Lahore.
Sajid Raihan, Khalid Safoorah, Mazari Nazish, Azhar Waleed, Khurshid Mohammad   +4 more
doaj  

cGMP Recombinant FIX for IV and Oral Hemophilia B Therapy [PDF]

, 2005
Three specific aims are proposed: Specific Aim # 1. Process engineer and scale-up the recovery and purification of transgenic recombinant human Factor IX.
Dernell, William, KEY PERSON, Julian, Cooper, LEAD INVESTIGATOR, Manning, Mark, LEAD INVESTIGATOR, Meagher, Michael, LEAD INVESTIGATOR, Mohanan, Paul, LEAD INVESTIGATOR, Nichols, Timothy, LEAD INVESTIGATOR, Stephan, Abramson, LEAD INVESTIGATOR, Swaanson, Todd, KEY PERSON, Van Cott, Kevin E., Velander, William H., PRINCIPAL INVESTIGATOR   +9 more
core   +1 more source

RESULTS OF AN OPEN, PROSPECTIVE, MULTICENTER, NONCOMPARATIVE STUDY OF THE PHARMACOKINETICS, EFFICACY AND SAFETY OF NONACOG ALFA IN PATIENTS AGED 6–12 YEARS WITH SEVERE AND MODERATE HEMOPHILIA B

, 2020
T. A. Andreeva, В. В. Лебедев, Vladimír Vdovin, M.A. Timofeeva, И. Л. Давыдкин, И. А. Лавриченко, O.A. Krasheninnikova, T.V. Asekretova, Pavel Svirin, V.Yu. Petrov, И. В. Куртов, E.E. Shiller, И.С. Тарасова, D.А. Kudlаy, E.V. Gapchenko, О. А. Markova, A.Yu. Borozinets   +16 more
openalex   +1 more source

Enhanced pharmacokinetic properties of a glycoPEGylated recombinant factor IX: a first human dose trial in patients with hemophilia B [PDF]

, 2011
Claude Négrier, Karin Knobe, Andreas Tiede, Paul Giangrande, Judi Møss   +4 more
openalex   +1 more source

Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics

Clinical Pharmacology &Therapeutics, Volume 118, Issue 6, Page 1329-1339, December 2025.
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou, Rohit Rao, Monica E. Shapiro, Nessy Tania, Cody Herron, Cynthia J. Musante, Jim H. Hughes   +6 more
wiley   +1 more source